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Astragalin [480-10-4]

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Cat# NB-64-37939-10mg

Size : 10mg

Brand : Neo Biotech

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Astragalin

(Synonyms: kaempferol-3-glucoside, Kaempferol 3-β-D-glucopyranoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside, Astragaline, 3-Glucosylkaempferol) Copy Product Info

Synonyms: kaempferol-3-glucoside, Kaempferol 3-β-D-glucopyranoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside, Astragaline, 3-Glucosylkaempferol

Catalog No. T6S1101 Copy Product Info

Purity: 99.98%

Astragalin (Kaempferol 3-O-glucoside) is a biologically active natural flavonoid. It has a variety of pharmacological properties, including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and cardioprotective properties.

Cas No. 480-10-4

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Color:White to Yellow

Product Information

Astragalin AI Summary

Astragalin is a multifaceted bioactive agent exhibiting a variety of pharmacological activities. It shows significant antiviral activity, particularly against HIV-1 IIIB replication in H9 cells (EC50 = 80.0 µg/mL) and influenza virus type A H1N1 in MDCK cells (IC50 values ranging from 24.5 to 35.8 µg/mL). It also inhibits mushroom tyrosinase diphenolase (IC50 = 0.074 mM), aldose reductase (IC50 = 5090.0 nM), and angiotensin-converting enzyme (ACE) in rat lung (IC50 = 180.0 µg/mL). In terms of antioxidant properties, Astragalin exhibits DPPH radical scavenging activity (IC50 > 100 µg/mL) and shows activity in ABTS assays (1.46 mM TEAC). Moreover, it demonstrates cytotoxicity against various cell lines, including mouse P388 cells (ED50 = 8.2 µg/mL), and exhibits anti-inflammatory effects by reducing nitric oxide and TNF-alpha levels in mouse RAW264.7 cells. The compound possesses notable antiprotozoal activity against Entamoeba histolytica and Giardia lamblia, with IC50 values of 61.2 and 47.5 µg/mL, respectively. Additionally, Astragalin shows promising antitubercular potential against Mycobacterium tuberculosis H37Rv (MIC > 128.0 µg/mL). In terms of metabolic effects, this compound reduces various fat depots and liver and plasma triglycerides in ddY mice. Additionally, it enhances adipogenesis in mouse 3T3L1 cells and shows neuroprotective properties by enhancing NGF secretion in rat C6 cells. It also plays a role in inhibiting various enzymes such as carbonic anhydrases and protein tyrosine phosphatases, thus demonstrating a broad enzymatic inhibitory profile. Furthermore, Astragalin shows anti-infective actions against Trypanosoma cruzi, with selective inhibitory concentrations for different forms and observable reductions in parasitemia in mouse models. The compound also exhibits selective cytotoxicity against various human cancer cell lines, including U251 and U87MG. Overall, Astragalin is a potent multi-target agent with a broad spectrum of biological activities, making it a compelling candidate for further pharmacological and therapeutic investigations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Astragalin (Kaempferol 3-O-glucoside) is a biologically active natural flavonoid. It has a variety of pharmacological properties, including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and cardioprotective properties.
Synonyms	kaempferol-3-glucoside, Kaempferol 3-β-D-glucopyranoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside, Astragaline, 3-Glucosylkaempferol

Chemical Properties

Molecular Weight	448.38
Formula	C₂₁H₂₀O₁₁
Cas No.	480-10-4
Smiles	OCC1OC(Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)C(O)C(O)C1O
Relative Density.	1.79 g/cm3

Storage & Solubility Information

Storage

Store at low temperature,Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (446.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2303 mL	11.1513 mL	22.3025 mL	111.5126 mL
5 mM	0.4461 mL	2.2303 mL	4.4605 mL	22.3025 mL
10 mM	0.2230 mL	1.1151 mL	2.2303 mL	11.1513 mL
20 mM	0.1115 mL	0.5576 mL	1.1151 mL	5.5756 mL
50 mM	0.0446 mL	0.2230 mL	0.4461 mL	2.2303 mL
100 mM	0.0223 mL	0.1115 mL	0.2230 mL	1.1151 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

proliferationNF-κBNFκBNF-kBNFkBmigrationKaempferol 3-beta-D-glucopyranosideKaempferol 3-b-D-glucopyranosideInhibitorinhibitbacteriostaticAstragalinApoptosisantioxidantanti-inflammatoryanticancer

Related Tags: Astragalin chemical structure | Astragalin formula | Astragalin molecular weight