A6003-5mg | c-Myc tag Peptide Clinisciences

c-Myc Peptide is a useful displacement of c-Myc-tagged fusion proteins bound to anti-c-Myc antibodies in immunoassays. The successful inhibition of antibody binding by c-Myc peptide demonstrates binding is specific. c-Myc peptide participates in regulation of growth-related gene transcription.

The c-Myc Peptide is a synthetic peptide with an amino acid sequence that corresponds to the amino acids 410-419 of the C-terminal of human c-myc. Myc (c-Myc) is a regulator gene that codes for a transcription factor. c-Myc activation results in numerous biological effects. The first to be discovered was its capability to drive cell proliferation (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation and stem cell self-renewal. C-Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. c-Myc overexpression stimulates gene amplification, [1] presumably through DNA over-replication.

References:
1. Denis N, Kitzis A, Kruh J, Dautry F, Corcos D (August 1991). "Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc". Oncogene 6 (8): 1453–7.

1. Wu Y, Jin S, et al. "Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression." Autophagy. 2020;1-14. PMID:32476569

Storage	Desiccate at -20°C
M.Wt	1203.3
Formula	C₅₁H₈₆N₁₂O₂₁
Synonyms	H-Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu-OH
Solubility	≥60.17 mg/mL in DMSO; insoluble in EtOH; ≥15.7 mg/mL in H2O with ultrasonic
Chemical Name	c-Myc Peptide
SDF	Download SDF
Canonical SMILES	N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Description	c-Myc tag Peptide is a synthetic peptide corresponding to the C-terminal amino acids (410-419) of human c-myc protein.
Targets	anti-c-Myc antibody
IC50