Clevudine
Cat# orb1300762-2mg
Size : 2mg
Brand : Biorbyt
Contact local distributor :
Phone : +1 850 650 7790
Clevudine
Catalog Number: orb1300762
| Catalog Number | orb1300762 |
|---|---|
| Category | Small Molecules |
| Description | Clevudine |
| CAS Number | 163252-36-6 |
| Purity | 99.98% |
| MW | 260.22 |
| SMILES | F[C@H]1[C@H](O[C@@H](CO)[C@@H]1O)N2C(=O)NC(=O)C(C)=C2 |
| Formula | C10H13FN2O5 |
| Biological Activity | Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |