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> FGFR4 Protein, Rat, Recombinant (His)

FGFR4 Protein, Rat, Recombinant (His)

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Cat# NB-64-57957-50ug

Size : 50ug

Brand : Neo Biotech


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FGFR4 Protein, Rat, Recombinant (His)

(Synonyms: fibroblast growth factor receptor 4) Copy Product Info

Synonyms: fibroblast growth factor receptor 4

Catalog No. TMPY-02862 Copy Product Info
FGFR4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.3 kDa and the accession number is Q498D6.
Other Forms of FGFR4 Protein, Rat, Recombinant (His):
FGFR4 Protein, Human, Recombinant (His & Avi)
FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR4 Protein, Rhesus macaque, Recombinant (His)
FGFR4 Protein, Human, Recombinant (hFc)
FGFR4 Protein, Mouse, Recombinant (His)
FGFR4 Protein, Mouse, Recombinant (His & hFc)
FGFR4 Protein, Human, Recombinant (His)
FGFR4 Protein, Rat, Recombinant (hFc)
FGFR4 Protein, Rhesus, Recombinant (hFc)
FGFR4 Protein, Human, Recombinant (His), Biotinylated
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
FGFR4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.3 kDa and the accession number is Q498D6.
Species
Rat
Expression System
HEK293 Cells
TagC-His
Accession NumberQ498D6
ConstructionA DNA sequence encoding the rat FGFR4 (Q498D6) (Met1-Asp367) was expressed, fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Phe 17
Protein Purity
> 95 % as determined by SDS-PAGE
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonymsfibroblast growth factor receptor 4
Research Background
Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Chemical Properties
Molecular Weight40.3 kDa (predicted); 64-68 kDa (reducing condition, due to glycosylation)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: FGFR4 Protein, Rat, Recombinant (His) chemical structure | FGFR4 Protein, Rat, Recombinant (His) molecular weight