Our FUS break apart probe is designed to detect FUS translocations. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: The FUS gene encodes an RNA-binding protein that serves as a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex.1 FUS shares distinct characteristics with EWSR1 and TAF15; the three genes are known as the FET family of proteins.1 FUS translocations contribute to oncogenesis in both solid tumors and leukemias, fusing the N-terminal end of FUS to various partner genes.2 The most frequent FUS rearrangement is t(12;16)(q13.3;p11.2), where it’s thought to drive tumorigenesis in myxoid liposarcoma by acting as a deregulated transcription factor on FUS and DDIT3 target genes.2
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Gene Details
Gene Symbol: FUS
Gene Name: FUS RNA Binding Protein
Chromosome: CHR16: 31191430-31206192
Locus: 16p11.2