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> Linalyl acetate [115-95-7]

Linalyl acetate [115-95-7]

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Cat# HY-N6948-500mg

Size : 500mg

Brand : MedChemExpress


Description

Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active[1][2][3][4].

In Vivo

Linalyl acetate (400 mg/kg, po, once daily for 15 days) stimulates the central nervous system, exhibits sedative and anti-anxiety effect in mouse models[2].
Linalyl acetate (1-100 mg/kg, ip, single dose) reduces the heart rate and LDH activity, relieves vasoconstriction. Linalyl acetate alleviates the cardiovascular and cell damage caused by acute nicotine exposure in mouse models[3].
Linalyl acetate (100 mg/kg, ip, twice weekly for 5 weeks) regulates the expression of inflammatory mediators, prevents mitochondrial dysfunction, exhibits anti-inflammatory and anti-fibrotic effects in rats collagen II-induced arthritis (CIA) models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mouse model[2].
Dosage: 400 mg/kg
Administration: po, once daily for 15 days
Result: Increased the time and number of entries in the open arm or bright chamber in the elevated plus maze and light-dark box tests.
Increased the motor activity in the open field test and the activity photoelectric instrument test.
Animal Model: Acute nicotine exposure in mouse models[3]
Dosage: 1-100 mg/kg
Administration: ip, single dose
Result: Reduced LDH activity, inhibited relaxation of mouse aortic rings, and improved the nitric oxide (NO) level in serum.
Animal Model: Collagen II-induced arthritis (CIA) rats models[4]
Dosage: 100 mg/kg
Administration: ip, twice weekly for 5 weeks
Result: Inhibited the increase in hind paw thickness, reduced serum IL-6 level, increased the gastrocnemius muscle weight and fiber cross-sectional area.
Molecular Weight

196.29

Formula

C12H20O2
CAS No.
Appearance

Liquid (Density: 0.8997 g/cm3)

Color

Colorless to light yellow

SMILES

CC(OC(CC/C=C(C)\C)(C)C=C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (509.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0945 mL 25.4725 mL 50.9450 mL
5 mM 1.0189 mL 5.0945 mL 10.1890 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (12.74 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (12.74 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Purity & Documentation
References