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> Mouse Monoclonal Anti-Desmoplakin 1/2, lyophilized, purified [Clone DP1 + 2-2.15]

Mouse Monoclonal Anti-Desmoplakin 1/2, lyophilized, purified [Clone DP1 + 2-2.15]

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Cat# 61003

Size : 50µg

Brand : Progen

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Phone : +1 850 650 7790

Disease related
Highly published

anti-Desmoplakin 1/2 mouse monoclonal, DP1 + 2-2.15, lyophilized, purified

anti-Desmoplakin 1/2 mouse monoclonal, DP1 + 2-2.15, lyophilized, purified
anti-Desmoplakin 1/2 mouse monoclonal, DP1 + 2-2.15, lyophilized, purified
anti-Desmoplakin 1/2 mouse monoclonal, DP1 + 2-2.15, lyophilized, purified
anti-Desmoplakin 1/2 mouse monoclonal, DP1 + 2-2.15, lyophilized, purified
E-cadherin binds to desmoglein to facilitate desmosome assembly.
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E-cadherin binds to desmoglein to facilitate desmosome assembly.
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E-cadherin binds to desmoglein to facilitate desmosome assembly.
View more
E-cadherin binds to desmoglein to facilitate desmosome assembly.
View more
E-cadherin binds to desmoglein to facilitate desmosome assembly.
View more
E-cadherin binds to desmoglein to facilitate desmosome assembly.
View more
E-cadherin binds to desmoglein to facilitate desmosome assembly.
View more
Product: anti-Desmoplakin 1/2 mouse monoclonal, DP1 + 2-2.15, lyophilized, purified
Art.No.: 61003

Quantity 50 µg
Antibody Type Monoclonal
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Application ICC/IF, IHC, WB
Purification Affinity chromatography
Reactivity Bovine, Chicken, Human, Mouse, Rat
Storage before reconstitution 2-8°C until indicated expiry date
Storage after reconstitution Up to 3 months at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Clone DP1 + 2-2.15
Immunogen Bovine desmoplakin 1 + 2
Concentration 50 µg/ml after reconstitution with 1 ml dist. water
Formulation Lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09% sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
UniprotID

A0A3Q1MR22 (Bovine), P15924 (Human), E9Q557 (Mouse), F1LMV6 (Rat)
Synonym Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP
Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) Assay dependent
Immunohistochemistry (IHC) - frozen 1:10-1:50
Immunohistochemistry (IHC) - paraffin 1:10-1:50 (microwave treatment recommended)
Western Blot (WB) Assay dependent

DP1 + 2-2.15 shows distinct punctate membrane staining of different epithelia. Tumors specifically detected: primary and metastatic carcinoma and meningioma. Polypeptides reacting: Desmoplakin 1 and 2 (Mr 250,000 and 215,000).

The epitope recognized by clone DP1 + 2-2.15 is mapped to the N-terminus of the rod domain (Bornslaeger, E. A., 1996).

Bornslaeger, E. A. Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. J. Cell Biol. 134, 985–1001 (1996).

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