MRE11A (Human) Cell-Based ELISA Kit

Qualitative

Entrez GeneID

Protein Accession#

Gene Name

MRE11A

Gene Alias

ATLD, HNGS1, MRE11, MRE11B

Gene Description

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Omim ID

Gene Ontology

Gene Summary

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq

Other Designations

AT-like disease|DNA recombination and repair protein|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog A