Phosphoinositide 3 Kinase, SH3 Binding Peptide (PI3K)
Cat# MBS659865-5x1mg
Size : 5x1mg
Brand : MyBiosource
Phosphoinositide 3 Kinase, SH3 Binding Peptide (PI3K) Peptide – Synthetic Peptide, ~90% by HPLC and MS analysis Purity
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS659865MBS659865 is a peptide targeting pik3r1-a. Also known as Phosphoinositide 3 Kinase, SH3 Binding Peptide (PI3K). Selective phosphoinositol 3-kinase SH3 ligand More details
Product Overview
Online Datasheet in PDFProduct Name
Phosphoinositide 3 Kinase, SH3 Binding Peptide (pik3r1-a), Peptide
Full Product Name
Phosphoinositide 3 Kinase, SH3 Binding Peptide (PI3K)
Product Gene Name
pik3r1-a peptide
Form/Format
Supplied as a lyophilized powder.
Purity/Purification
Highly Purified
~90% by HPLC and MS analysis
~90% by HPLC and MS analysis
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
1174
Sequence (linear)
H2N-Arg-Lys-Leu-Pro-Pro-Arg-Pro-Arg-Arg-OH
Phosphoinositide 3 kinase (PI3K) is a kinase catalyzing the phosphorylation of PI(4,5)P2 at the D3 position of the inositol ring. The resulting product PI(3,4,5)P3 can be recognized by PH domain-containing signaling molecules, including various kinases and their regulators, and activates the corresponding cell signaling pathways, eventually leading to cell growth, survival and cellular movement (1). PI3K is a heterodimer with a p85 regulatory subunit and p110 catalytic subunit. The p85 subunit has two SH2 domains binding to phospho-tyrosine with the consensus motif (Y*XXM) where X denotes any amino acid and Y* is phosphorylated tyrosine. This motif exists in many of the receptor tyrosine kinases and their substrates, such as EGFR, FGFR, IRS-1, BCAP and GAB1 (2,3). The docking of PI3K in the membrane vicinity through p85 recognization of the phosphorylated YXXM in signaling molecules activates the PI3K pathway. Phospho-(Tyr) p85 PI3K Binding Motif Antibody specifically recognizes PI3K binding targets at their phosphorylated YXXM motif, providing a powerful new tool for PI3K binding protein discovery and characterization as well as HTS drug screening for potential regulators.
Phosphoinositide 3 kinase (PI3K) is a kinase catalyzing the phosphorylation of PI(4,5)P2 at the D3 position of the inositol ring. The resulting product PI(3,4,5)P3 can be recognized by PH domain-containing signaling molecules, including various kinases and their regulators, and activates the corresponding cell signaling pathways, eventually leading to cell growth, survival and cellular movement (1). PI3K is a heterodimer with a p85 regulatory subunit and p110 catalytic subunit. The p85 subunit has two SH2 domains binding to phospho-tyrosine with the consensus motif (Y*XXM) where X denotes any amino acid and Y* is phosphorylated tyrosine. This motif exists in many of the receptor tyrosine kinases and their substrates, such as EGFR, FGFR, IRS-1, BCAP and GAB1 (2,3). The docking of PI3K in the membrane vicinity through p85 recognization of the phosphorylated YXXM in signaling molecules activates the PI3K pathway. Phospho-(Tyr) p85 PI3K Binding Motif Antibody specifically recognizes PI3K binding targets at their phosphorylated YXXM motif, providing a powerful new tool for PI3K binding protein discovery and characterization as well as HTS drug screening for potential regulators.
Amino Acid Analysis
Confirms expected sequence
Peptide Content: 81.2 ± 4%
Peptide Content: 81.2 ± 4%
Solubility
H2O
Product Categories/Family for pik3r1-a peptide
Molecular Biology; MB-Protein Kinases
Other Notes
Small volumes of pik3r1-a peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for pik3r1-a. It may not necessarily be applicable to this product.
NCBI Official Full Name
phosphoinositide-3-kinase
NCBI Official Symbol
pik3r1-a
NCBI Official Synonym Symbols
pik3r1
UniProt Protein Name
Phosphatidylinositol 3-kinase regulatory subunit alpha
UniProt Synonym Protein Names
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
UniProt Gene Name
pik3r1-a
UniProt Synonym Gene Names
PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha
UniProt Entry Name
P85AA_XENLA
NCBI Protein Information
phosphatidylinositol 3-kinase regulatory subunit alpha; ptdIns-3-kinase p85-alpha; PI3-kinase p85 subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
UniProt Comments for pik3r1-a
Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane
By similarity.
Subunit structure: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits
By similarity.
Sequence similarities: Belongs to the PI3K p85 subunit family.Contains 1 Rho-GAP domain.Contains 2 SH2 domains.Contains 1 SH3 domain.
Show more By similarity.
Subunit structure: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits
By similarity.
Sequence similarities: Belongs to the PI3K p85 subunit family.Contains 1 Rho-GAP domain.Contains 2 SH2 domains.Contains 1 SH3 domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with pik3r1-a peptide
| Products by Pathway | Pathway Diagram |
|---|---|
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
| ErbB Signaling Pathway antibodies | ErbB Signaling Pathway Diagram |
| ErbB Signaling Pathway antibodies | ErbB Signaling Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
| Insulin Signaling Pathway antibodies | Insulin Signaling Pathway Diagram |
| Insulin Signaling Pathway antibodies | Insulin Signaling Pathway Diagram |
| Jak-STAT Signaling Pathway antibodies | Jak-STAT Signaling Pathway Diagram |
| Jak-STAT Signaling Pathway antibodies | Jak-STAT Signaling Pathway Diagram |
Organs/Tissues associated with pik3r1-a peptide
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >12 publications with pik3r1-a and Brain |
| Spleen Antibodies | >3 publications with pik3r1-a and Spleen |
| Ovary Antibodies | >3 publications with pik3r1-a and Ovary |
| Whole Body Antibodies | >3 publications with pik3r1-a and Whole Body |