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> Polyclonal Rabbit anti-Mouse KISS1R / GPR54 Antibody (Rhodamine, aa375-396)

Polyclonal Rabbit anti-Mouse KISS1R / GPR54 Antibody (Rhodamine, aa375-396)

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Cat# LS-C183897-100

Size : 100ul

Brand : LSBio



KISS1R / GPR54

KISS1 receptor

Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

Publications (5)

1
KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse model. McNally LR, Welch DR, Beck BH, Stafford LJ, Long JW, Sellers JC, Huang ZQ, Grizzle WE, Stockard CR, Nash KT, Buchsbaum DJ. Clinical & experimental metastasis. 2010 27:591-600. (Flo) [Full Text Article] [PubMed:20844932] [PMC:PMC2975384] Related Antibodies: LS-A1929.
2
The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis. Arlene J George, Bin Dong, Hannah Lail, Morgan Gomez, Yarely C Hoffiz, Christopher B Ware, Ning Fang, Anne Z Murphy, Erik Hrabovszky, Desiree Wanders, Angela M Mabb. iScience. 2022 June;25:104386. [Full Text Article] [PubMed:35620441] [PMC:PMC9126796] Related Antibodies: LS-B15332.
3
Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas. Chen Y, Yusenko MV, Kovacs G. The Journal of pathology. 2011 Jan;223:46-53. [Full Text Article] [PubMed:20922711] Related Antibodies: LS-A1929.
4
Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma. Prentice LM, Klausen C, Kalloger S, K[Character f6]bel M, McKinney S, Santos JL, Kenney C, Mehl E, Gilks CB, Leung P, Swenerton K, Huntsman DG, Aparicio SA. BMC medicine. 2007 5:33. [Full Text Article] [PubMed:18005407] [PMC:PMC2200658] Related Antibodies: LS-A1929.
5
GPR54 is a target for suppression of metastasis in endometrial cancer. Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, Kondoh E, Yoshioka Y, Oishi S, Fujii N, Murphy SK, Konishi I. Molecular cancer therapeutics. 2011 Apr;10:580-90. [Full Text Article] [PubMed:21282360] Related Antibodies: LS-A1927.
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Antibodies (27)
ELISA Kits (8)
Competitive EIA (1)
Custom (2)
Primary (27)
Sandwich (5)
KISS1R / GPR54 (35)
Human (23)
Mouse (6)
Rat (14)
Bat (1)
Bovine (2)
Dog (1)
Goat (1)
Hamster (1)
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IHC (8)
IHC-P (5)
WB (18)
Flo (1)
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IP (8)
Peptide-ELISA (2)
rabbit (27)
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IHCPlus (3)
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polyclonal pc (27)
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APC Conjugated (1)
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Cy3 Conjugated (1)
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HRP Conjugated (1)
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Unconjugated (20)
C-Terminus (2)
270-350 aa, C-terminal (1)
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Extracellular Domain (1)
N-Terminus (1)
aa235-263 (1)
aa301-350 (1)
aa375-398 (1)
No (32)
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Serum (3)
Tissue Homogenates (4)