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> Prostaglandin D2 [41598-07-6]

Prostaglandin D2 [41598-07-6]

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Cat# 366908-10mg

Size : 10mg

Brand : US Biological


366908 Prostaglandin D2

Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

Prostaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma. Prostaglandin D2 is the major postagrlandin produced by mast cells and is the primary prostaglandin in the brain. It causes vasodilation, induces inflammation, and its presence in hair follicles may be partially responsible for male pattern baldness. Prostaglandin D2 is released during asthmatic and allergic reactions.

Synonyms:
(Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid; 11-Dehydroprostaglandin F2alpha, PGD2

CAS Number:
41598-07-6

Molecular Formula:
C20H32O5

Molecular Weight:
352.5

Appearance:
White to off-white solid

Purity:
≥98%

Applications:
FA

Solubility:
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 50mg/ml.

Storage and Stability:
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Form
White to off-white solid
Purity
≥98%
References
1. Murray, J. J., Tonnel, A. B., Brash, A. R., Roberts, L. J., Gosset, P., Workman, R., ... Oates, J. A. (1986). Release of prostaglandin D2 into human airways during acute antigen challenge. New England Journal of Medicine, 315(13), 800-804. 2. Monneret, G., Gravel, S., Diamond, M., Rokach, J., Powell, W. S. (2001). Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood, 98(6), 1942-1948. 3. Garza, L. A., Liu, Y., Yang, Z., Alagesan, B., Lawson, J. A., Norberg, S. M., ... Cotsarelis, G. (2012). Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Science translational medicine, 4(126), 126ra34-126ra34.