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Salbutamol [18559-94-9]

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Cat# NB-64-02672-1mL

Size : 1mLx10mM(inDMSO)

Brand : Neo Biotech

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Salbutamol

(Synonyms: Albuterol, AH-3365) Copy Product Info

Synonyms: Albuterol, AH-3365

Catalog No. T1139 Copy Product Info

Purity: 99.9%

Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Increased cAMP concentrations relax the bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent, Salbutamol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.

Cas No. 18559-94-9

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Purity:99.9%

Appearance:Solid

Color:White

Product Information

Bioactivity

Description	Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Increased cAMP concentrations relax the bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent, Salbutamol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.
Synonyms	Albuterol, AH-3365

Chemical Properties

Molecular Weight	239.3107
Formula	C₁₃H₂₁NO₃
Cas No.	18559-94-9
Smiles	CC(C)(C)NCC(O)C1=CC(CO)=C(O)C=C1
Relative Density.	1.152 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255.00 mg/mL (1065.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 10 mg/mL (41.79 mM), Solution.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (8.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1787 mL	20.8933 mL	41.7867 mL	208.9334 mL
5 mM	0.8357 mL	4.1787 mL	8.3573 mL	41.7867 mL
10 mM	0.4179 mL	2.0893 mL	4.1787 mL	20.8933 mL
20 mM	0.2089 mL	1.0447 mL	2.0893 mL	10.4467 mL
50 mM	0.0836 mL	0.4179 mL	0.8357 mL	4.1787 mL
100 mM	0.0418 mL	0.2089 mL	0.4179 mL	2.0893 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

β-adrenergic receptorSalbutamolInhibitorinhibitBeta ReceptorAH3365AH 3365AdrenergicReceptorAdrenergic Receptor

Related Tags: Salbutamol chemical structure | Salbutamol formula | Salbutamol molecular weight