SMAD4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommended Dilution	WB: 1:500-1:3000
Reactivities	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	The immunogen for anti-Smad4 Antibody: A synthesized peptide derived from human Smad4
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Affinity-chromatography
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Predicted Protein Size	60 kDa
Gene Name	SMAD family member 4
Database Link	NP_005350 Entrez Gene 17128 MouseEntrez Gene 50554 RatEntrez Gene 4089 Human UniProt ID Q13485
Background	Smad4 transcription factor that mediates signal transduction by the transforming growth factor superfamily. The common smad (co-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. Promotes binding of the Smad2/Smad4/Fast-1 complex to DNA and provides an activation function required for Smad1 or Smad2 to stimulate transcription.
Synonyms	DPC4; JIP; MADH4; MYHRS
Note	Smad4 antibody detects endogenous levels of total Smad4
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Adherens junction, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway, Wnt signaling pathway