Sodium Butyrate
Cat# M5152-5g
Size : 5g
Brand : AbMole Bioscience
Butanoic acid sodium salt
Quality Control & Documentation
Biological Activity
Sodium butyrate is the sodium salt of butyric acid, used in the culture of mammalian cells. Sodium butyrate inhibits most HDAC except class III HDAC and class II HDAC6 and -10. Sodium butyrate also is the most effective fatty acid in stimulating or repressing the expression of specific genes. Sodium butyrate induces p21 mRNA expression in an immediate-early fashion, through transactivation of a promoter cis-element(s) located within 1.4 kb of the transcriptional start site, independent of p53 binding. Sodium butyrate significantly extends survival in a dose-dependent manner, improves body weight and motor performance, and delays the neuropathological sequelae in the R6/2 transgenic mouse model of Huntington's disease (HD). Sodium butyrate also increases histone and specificity protein-1 acetylation and protects against 3-nitropropionic acid neurotoxicity. Can be used to construct animal models of venous stenosis.
Product Citations
-
J Virol. 2020 Feb 14;94(5):e01791-19.
Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use
Sodium Butyrate purchased from AbMole
Chemical Information
Molecular Weight | 110.09 |
Formula | C4H7NaO2 |
CAS Number | 156-54-7 |
Solubility (25°C) | Water 90 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Hamer HM, et al. Aliment Pharmacol Ther. Review article: the role of butyrate on colonic function.
[2] Davie JR. J Nutr. Inhibition of histone deacetylase activity by butyrate.
[3] Sealy L, et al. Cell. The effect of sodium butyrate on histone modification.