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Sodium Butyrate

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Cat# M5152-500mg

Size : 500mg

Brand : AbMole Bioscience

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Phone : +1 850 650 7790

Sodium Butyrate Structure
Synonym:

Butanoic acid sodium salt

Quality Control & Documentation
Biological Activity

Sodium butyrate is the sodium salt of butyric acid, used in the culture of mammalian cells. Sodium butyrate inhibits most HDAC except class III HDAC and class II HDAC6 and -10. Sodium butyrate also is the most effective fatty acid in stimulating or repressing the expression of specific genes. Sodium butyrate induces p21 mRNA expression in an immediate-early fashion, through transactivation of a promoter cis-element(s) located within 1.4 kb of the transcriptional start site, independent of p53 binding. Sodium butyrate significantly extends survival in a dose-dependent manner, improves body weight and motor performance, and delays the neuropathological sequelae in the R6/2 transgenic mouse model of Huntington's disease (HD). Sodium butyrate also increases histone and specificity protein-1 acetylation and protects against 3-nitropropionic acid neurotoxicity. Can be used to construct animal models of venous stenosis.

Product Citations

  • J Virol. 2020 Feb 14;94(5):e01791-19.

    Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use
    Sodium Butyrate purchased from AbMole

Chemical Information
Molecular Weight 110.09
Formula C4H7NaO2
CAS Number 156-54-7
Solubility (25°C) Water 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hamer HM, et al. Aliment Pharmacol Ther. Review article: the role of butyrate on colonic function.

[2] Davie JR. J Nutr. Inhibition of histone deacetylase activity by butyrate.

[3] Sealy L, et al. Cell. The effect of sodium butyrate on histone modification.