Sodium Channel Protein Type 8 subunit alpha (Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6, SCN8A, MED)

Sodium channel protein type 8 subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes. Adopting opened or closed conformation in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na ions may pass in accordance with their electrochemical gradient. It is a multi-pass transmembrane protein that is widely expressed in neurons of the central and peripheral nervous system. There are four named isoforms. The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment, S4. Segments S4 are thought to be the voltage-sensors and are characterised by a series of positively charged amino acids at every third position.

Suitable for use in Immunofluorescence, ELISA and Western Blot. Other applications not tested.

Immunofluorescence: 10ug/ml
Optimal dilutions to be determined by the researcher.

Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Mab

IgG2a,k

9G446

mouse

human

~1mg/ml (after reconstitution)

Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.

Purified by Protein G affinity chromatography.

Partial recombinant human Sodium channel protein type 8 subunit alpha (aa1854-1951) with a GST tag.

Recognizes human sodium channel protein. Species Crossreactivity

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.