OPPA02022 | SOX9 Protein Clinisciences

Datasheets/Manuals	Printable datasheet for OPPA02022

Product Info
Product Format	SOX9 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol. Physical appearance: Sterile Filtered clear solution.
Host	E. Coli
::	Product Introduction: SOX9 is involved in skeletal development. SOX9 regulates the expression of other genes which play a role in chondrogenesis by performing as a transcription factor for these genes. SOX9 takes part in chondrocyte differentiation and, together with steroidogenic factor 1; SOX9 regulates transcription of the anti-Muellerian hormone gene. Deficiencies of SOX9 result in skeletal malformation syndrome campomelic dysplasia, often with sex reversal. SOX9 is a transcription factor having vast mobility group DNA-binding domain that is expressed in all prechondrocytic and chondrocytic cells throughout embryonic growth. SOX9 Phosphorylation by PKA raises its DNA binding and transcriptional activity. SOX9 controls expression of chondrocyte phenotype related genes. IL-1 and TNF-a decrease SOX9 levels of mRNA and/or protein in chondrocytes, therefore strongly inhibit the expression of genes for cartilage extracellular matrix proteins. SOX9 down-regulation takes part in inhibiting expression of the cartilage phenotype in inflammatory joint diseases. Product Description: SOX9 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 150 amino acids (1-150 a.a.) fused to a GST tag and having a total molecular mass of 43kDa. The SOX9 is purified by proprietary chromatographic techniques.
Reconstitution and Storage	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Please avoid freeze thaw cycles.

Gene Symbol	SOX9 150a.a.
Alias Symbols	CMD1, SRA1, CMPD1, SRXX2, SRXY10
NCBI Gene Id	6662
Protein Name	Transcription factor SOX-9
Description of Target	Recombinant Human SOX9 150 a.a.
Uniprot ID	P48436
Protein Accession #	NP_000337.1

Protein interactions

Name	# of Products
CREB1	152
CREB3L4	9
CREBBP	802
EP300	986
HSPA1A	134
KPNB1	204
MAF	45
MED12	109
NR5A1	65
RUNX2	72
SCXA	4
SMAD2	408
SMAD3	511
SPEN	47
TRAF2	432

Biological pathways

Name	# of Products
CAMP-mediated signaling	20
Cartilage condensation	9
Cell fate specification	22
Cellular response to epidermal growth factor stimulus	13
Cellular response to heparin	16
Cellular response to interleukin-1	50
Cellular response to mechanical stimulus	218
Cellular response to retinoic acid	80
Cellular response to transforming growth factor beta stimulus	51
Chondrocyte differentiation involved in endochondral bone morphogenesis	4
Chondrocyte hypertrophy	4
Chromatin remodeling	82
Cochlea morphogenesis	27
Endocardial cushion morphogenesis	5
Epidermal growth factor receptor signaling pathway	240
Epithelial cell proliferation involved in prostatic bud elongation	4
Epithelial to mesenchymal transition	90
ERK1 and ERK2 cascade	56
Hair follicle development	22
Intestinal epithelial structure maintenance	20
Male germ-line sex determination	4
Metanephric nephron tubule formation	16
Negative regulation of apoptotic process	538
Negative regulation of canonical Wnt receptor signaling pathway	97
Negative regulation of chondrocyte differentiation	21
Negative regulation of epithelial cell proliferation	52
Negative regulation of immune system process	4
Negative regulation of myoblast differentiation	24
Negative regulation of photoreceptor cell differentiation	4
Negative regulation of transcription, DNA-dependent	660
Nucleosome assembly	90
Otic vesicle formation	13
Positive regulation of branching involved in ureteric bud morphogenesis	57
Positive regulation of cartilage development	32
Positive regulation of chondrocyte differentiation	18
Positive regulation of epithelial cell differentiation	6
Positive regulation of epithelial cell migration	24
Positive regulation of epithelial cell proliferation	124
Positive regulation of male gonad development	18
Positive regulation of mesenchymal cell proliferation	87
Positive regulation of mesenchymal stem cell differentiation	12
Positive regulation of phosphatidylinositol 3-kinase cascade	210
Positive regulation of protein phosphorylation	102
Protein complex assembly	152
Regulation of cell cycle process	8
Regulation of cell proliferation involved in tissue homeostasis	4
Renal vesicle induction	7
Retinal rod cell differentiation	7
Somatic stem cell maintenance	26
Spermatogenesis	232

Biological process

Name	# of Products
Astrocyte fate commitment	5
CAMP-mediated signaling	19
Cartilage condensation	16
Cartilage development	76
Cell fate specification	23
Cellular response to epidermal growth factor stimulus	7
Cellular response to heparin	6
Cellular response to interleukin-1	32
Cellular response to mechanical stimulus	62
Cellular response to retinoic acid	44
Cellular response to transforming growth factor beta stimulus	27
Chondrocyte differentiation involved in endochondral bone morphogenesis	2
Chondrocyte hypertrophy	1
Chromatin remodeling	61
Cochlea morphogenesis	24
Endocardial cushion morphogenesis	6
Endochondral bone morphogenesis	1
Endocrine pancreas development	50
Epidermal growth factor receptor signaling pathway	124
Epithelial cell proliferation involved in prostatic bud elongation	1
Epithelial to mesenchymal transition	31
ERK1 and ERK2 cascade	27
Extracellular matrix organization	77
Hair follicle development	35
Heart valve development	1
Heart valve formation	2
Heart valve morphogenesis	2
Intestinal epithelial structure maintenance	3
Intrahepatic bile duct development	1
Limb bud formation	14
Male germ-line sex determination	1
Male gonad development	78
Mammary gland development	47
Metanephric nephron tubule formation	6
Metanephric tubule development	2
Morphogenesis of a branching epithelium	2
Negative regulation of apoptotic process	356
Negative regulation of biomineral tissue development	1
Negative regulation of bone mineralization	15
Negative regulation of canonical Wnt receptor signaling pathway	67
Negative regulation of chondrocyte differentiation	12
Negative regulation of epithelial cell proliferation	44
Negative regulation of immune system process	1
Negative regulation of myoblast differentiation	12
Negative regulation of ossification	21
Negative regulation of photoreceptor cell differentiation	7
Negative regulation of transcription, DNA-dependent	520
Neural crest cell development	18
Notochord development	10
Nucleosome assembly	66
Oligodendrocyte differentiation	15
Otic vesicle development	7
Otic vesicle formation	9
Positive regulation of branching involved in ureteric bud morphogenesis	26
Positive regulation of cartilage development	13
Positive regulation of cell proliferation	483
Positive regulation of cell proliferation involved in heart morphogenesis	1
Positive regulation of chondrocyte differentiation	18
Positive regulation of epithelial cell differentiation	4
Positive regulation of epithelial cell migration	14
Positive regulation of epithelial cell proliferation	82
Positive regulation of kidney development	11
Positive regulation of male gonad development	8
Positive regulation of mesenchymal cell proliferation	47
Positive regulation of mesenchymal stem cell differentiation	3
Positive regulation of phosphatidylinositol 3-kinase cascade	60
Positive regulation of protein catabolic process	28
Positive regulation of protein phosphorylation	125
Positive regulation of transcription from RNA polymerase II promoter	968
Positive regulation of transcription, DNA-dependent	681
Prostate gland development	10
Prostate gland morphogenesis	3
Protein complex assembly	100
Protein kinase B signaling cascade	39
Protein phosphorylation	451
Regulation of apoptotic process	223
Regulation of cell adhesion	41
Regulation of cell cycle process	4

Cellular components

Name	# of Products
Chromatin remodeling complex	15
Nucleolus	1179
Nucleus	4914
Protein complex	216

Protein function

Name	# of Products
Beta-catenin binding	138
Chromatin binding	670
Core promoter sequence-specific DNA binding	34
Enhancer binding	21
Enhancer sequence-specific DNA binding	32
Protein binding	12191
Protein kinase A catalytic subunit binding	12
Protein kinase activity	636
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	177
Sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	418
Sequence-specific DNA binding transcription factor activity	2776

Diseases

Name	# of Products
Disease mutation	5332

SOX9 Protein

Cat# OPPA02022

Contact local distributor :

Brand : Aviva Systems Biology

Contact local distributor :