PathPlus™ TPSAB1 / Mast Cell Tryptase Antibody
Cat# LS-B14330-50
Size : 50ul
Brand : LSBio
Contact local distributor :
Phone : +1 850 650 7790
Overview
Antibody:
TPSAB1 / Mast Cell Tryptase Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, IF, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Tryptase alpha/beta 1 (TPSAB1) is one of two adjacent genes (TPSAB1, TPSB2) that code for mast cell tryptase, a serine protease. Mast cell tryptase is the predominant isoenzyme in mast cells. It is often used as a marker for mast cell activation, and high levels of tryptase can be an indicator of anaphylaxis, mastocytosis or the presence of eosinophilic leukemia. In immunohistochemistry, antibodies to mast cell tryptase stain secretory granules of mast cells. References: J Biol Chem. 1999. 274 (6): 3355–62,PMID: 9920877; Nat Genet. 2016 Dec;48(12):1564-1569, PMID: 27749843; Proceedings of the National Academy of Sciences of the United States of America. 1990 May. 87 (10): 3811–5, PMID: 2187193; Cancer Research. 2017 Mar. 77 (6): 1261–1270, PMID: 28254862; Am. J. Clin. Path. 2015 Sept. 144 (3): 377–92, PMID 26276769; Anaesthesia. 2004 Jul;59(7):695-703, PMID: 15200544
Target
Human TPSAB1 / Mast Cell Tryptase
Synonyms
TPSAB1 | Alpha tryptase | Mast cell alpha II tryptase | Tryptase alpha-1 | Tryptase beta I | Tryptase-III | TPSB1 | Tryptase alpha II | TPS1 | TPS2 | Tryptase beta-1 | Tryptase-1 | Tryptase-I | Mast cell beta I tryptase | Tryptase alpha/beta 1 | Tryptase alpha/beta-1 | Tryptase beta 1 | Tryptase I
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Recombinant full length Human TPSAB1.
Specificity
Human TPSAB1 / Mast Cell Tryptase
Applications
- IHC
- IHC - Paraffin (2.5 - 5 µg/ml)
- Immunofluorescence (1:50 - 1:200)
- Western blot (1:500 - 1:2000)
Presentation
PBS, 0.1% Sodium Azide, 50% Glycerol
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee About TPSAB1 / Mast Cell Tryptase
Q15661 NM_003294 NP_003285.2
Validation
Human Colon, mast cells: Formalin-Fixed, Paraffin-Embedded (FFPE)
Request SDS/MSDS
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