α-MSH [581-05-5]

Biological Activity

α-MSH (α-Melanocyte-stimulating hormone) is an anti-inflammatory agent stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α-MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α-MSH has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Chemical Information

Molecular Weight	1664.88
Formula	C77H109N21O19S
CAS Number	581-05-5
Solubility (25°C)	Water ≥ 15 mg/mL
Storage	-20°C, dry, protect from light, sealed

References

[1] Minhyeok Song, et al. Mar Drugs. Jeju Magma-Seawater Inhibits α-MSH-Induced Melanogenesis via CaMKKβ-AMPK Signaling Pathways in B16F10 Melanoma Cells

[2] Seung-Ho Seo, et al. Molecules. Metabolomics Reveals the Alteration of Metabolic Pathway by Alpha-Melanocyte-Stimulating Hormone in B16F10 Melanoma Cells

[3] Hye Yeon Lim, et al. Int J Mol Sci. Antiwrinkle and Antimelanogenesis Effects of Tyndallized Lactobacillus acidophilus KCCM12625P

[4] Wisurumuni Arachchilage, et al. Biomolecules. Anthocyanins from Hibiscus syriacus L. Inhibit Melanogenesis by Activating the ERK Signaling Pathway

[5] Ga-Young Seo, et al. Int J Mol Sci. Leathesia difformis Extract Inhibits α-MSH-Induced Melanogenesis in B16F10 Cells via Down-Regulation of CREB Signaling Pathway

[6] Hyeju Jo, et al. Bioorg Med Chem Lett. Synthesis and Biological Evaluation of Caffeic Acid Derivatives as Potent Inhibitors of α-MSH-stimulated Melanogenesis

[7] Taek-In Oh, et al. Int J Mol Sci. Plumbagin Suppresses α-MSH-Induced Melanogenesis in B16F10 Mouse Melanoma Cells by Inhibiting Tyrosinase Activity

[8] Xin-Yun Lu, et al. J Neurosci. Interaction Between Alpha-Melanocyte-Stimulating Hormone and Corticotropin-Releasing Hormone in the Regulation of Feeding and Hypothalamo-Pituitary-Adrenal Responses