2',3'-cGAMP
Referencia NU-249L
embalaje : 5x1µmol
Marca : Jena Bioscience
2',3'-cyclic GMP-AMP
Cyclic-(guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate), Sodium salt

For general laboratory use.
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C20H24N10O13P2 (free acid)
Molecular Weight: 674.42 g/mol (free acid)
Exact Mass: 674.10 g/mol (free acid)
Purity: ≥ 98 % (HPLC) / ≤ 2.5 EU/ml Endotoxin (LAL test)
Form: solid (lyophilized from filtered (10 kDa) solution in water)
Color: white to off-white
Spectroscopic Properties: λmax 260 nm, ε 25.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
BIOZ Product Citations:
Selected References:
Li et al. (2018) The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer. J. Exp. Med. 215 (5):1287.
Li et al. (2016) Antitumor activity of cGAMP via stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response. Nature Scientific Reports 6:19049.
Tao et al. (2016) cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling. IUBMB Life 68 (11):858.
Temizoz et al. (2015) TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur. J. Immunol. 45:1159.