embalaje : 500mg
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Ademetionine (S-adenosylmethionine; SAMe) is a naturally occurring metabolite present in all cells and biological fluids, and acts as a methyl donor in a variety of methylation reactions involving proteins, phospholipids, catecholamines and DNA. Ademetionine exhibits antidepressant activity associated with increases in brain monoamine neurotransmitters and improvement in muscarinic and β-adrenergic receptor functions. In addition, preliminary studies imply that ademetionine exhibits therapeutic potential in the treatment of other central nervous system disorders including dementia, acquired immune deficiency syndrome-associated myelopathy, as well as brain ischemia.
Reference:
1. Bottiglieri T. Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders. Expert Opinion on Investigational Drugs, 1997, 6(4): 417-426.
Animal models
Mice and rats
Dosage form
12.5, 25, 50, 100 and 200 mg/kg
Subcutaneous injection
Applications
Ademetionine dose-dependently decreased immobility time in the forced swimming test in mice and rats, and the effect could be antagonized by haloperiodol.
Note
The technical data provided above is for reference only.
References: