General Info
| Host: | Armenian Hamster |
| Applications: | FC |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Armenian Hamster monoclonal antibody anti-CD48 antigen is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | HM48-1 |
| Conjugation: | APC |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 1% BSA |
| Concentration: | 0.2 mg/mL |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
| Gene Symbol: | Cd48 |
| Gene ID: | 12506 |
| Uniprot ID: | CD48_MOUSE |
Description
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenBcm1 Surface AntigenBlast-1Hm48-1Mrc Ox-45 Surface AntigenSlam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Sgp-60Cd Antigen Cd48 |
| Database Links | Reactome: R-MMU-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibodyAnti-Bcm1 Surface Antigen antibodyAnti-Blast-1 antibodyAnti-Hm48-1 antibodyAnti-Mrc Ox-45 Surface Antigen antibodyAnti-Slam Family Member 2 antibodyAnti-Slamf2 antibodyAnti-Signaling Lymphocytic Activation Molecule 2 antibodyAnti-Sgp-60 antibodyAnti-Cd Antigen Cd48 antibodyAnti-Cd48 antibodyAnti-Bcm-1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance