General Info
Host: | Goat |
Applications: | WB/IHC-F/IHC-P/IF |
Reactivity: | Human/Rat/Mouse/Monkey/Canine |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-Lysosome-associated membrane glycoprotein 3 (120aa to 175aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS, 20% Glycerol and 0.05% Sodium Azide. |
Purification: | This antibody is epitope-affinity purified from goat antiserum. |
Concentration: | 3 mg/ml |
Dilution Range: | WB 1:500-1:5000IF 1:25-1:250IHC-F 1:250-1:1000IHC-P 1:250-1:1000Amorim M Martins B Caramelo F et al. Front Med-Lausanne 2022 May PMID: 35692536Matsui T Sakamaki Y Nakashima S et al. Cell Rep 2022 May PMID: 35649370Martin |
Storage Instruction: | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
Information
Gene Symbol: | LAMP3 |
Gene ID: | 27074 |
Uniprot ID: | LAMP3_HUMAN |
Immunogen Region: | 120aa to 175aa |
Accession Number: | ENSG00000135404 |
Specificity: | Reacts with CD63, a 40-60 kDa glycoprotein, detected by Western blot in the following human (HeLa, HUH, Jurkat) , mouse (AtT-20, Hepa, 3T3, RAW264.7) , canine (MDCK) and monkey (COS-7) whole cell lysates. |
Immunogen: | Purified recombinant peptide derived from within residues 120 aa to 175 aa of human CD63 produced in E. coli. |
Immunogen Sequence: | MENYPKNNHTASILDRMQAD FKCCGAANYTDWEKIPSMSK NRVPDSCCI |
Description
Tissue Specificity | Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. |
Function | Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity. (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium. |
Protein Name | Lysosome-Associated Membrane Glycoprotein 3Lamp-3Lysosomal-Associated Membrane Protein 3Dc-Lysosome-Associated Membrane GlycoproteinDc LampProtein Tsc403Cd Antigen Cd208 |
Cellular Localisation | Cell SurfaceLysosome MembraneSingle-Pass Type I Membrane ProteinCytoplasmic Vesicle MembraneEarly Endosome MembraneDuring Dendritic Cell MaturationDetected On Cytoplasmic Vesicles (The Mhc Ii Compartment) That Contain Mhc Ii ProteinsLamp1Lamp2 And Lamp3Detected On Lysosomes In Mature Dendritic Cells |
Alternative Antibody Names | Anti-Lysosome-Associated Membrane Glycoprotein 3 antibodyAnti-Lamp-3 antibodyAnti-Lysosomal-Associated Membrane Protein 3 antibodyAnti-Dc-Lysosome-Associated Membrane Glycoprotein antibodyAnti-Dc Lamp antibodyAnti-Protein Tsc403 antibodyAnti-Cd Antigen Cd208 antibodyAnti-LAMP3 antibodyAnti-DCLAMP antibodyAnti-TSC403 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance