E3 ubiquitin-protein ligase RNF146, RING finger protein 146 or Iduna is encoded by the gene RNF146. Iduna is a ubiquitin protein ligase that is involved in ubiquitination and degradation. It is thought to be involved with diverse processes including DNA repair, activation of the Wnt signaling pathway, protection from DNA damage induced cell death. Iduna is found in many tissues including brain, heart, spleen, kidney and liver.
Purified by Protein A chromatography
Lot dependent: provided at 0.3-0.5 mg/mL
Monoclonal
N201/35
IgG1
ICC
Mouse
Rnf146
40 kDa
Fusion protein amino acids 1-359 (full-length) of mouse Iduna (accession number Q9CZW6) produced recombinantly in E. Coli
Mouse
Human, Mouse, Rat
AB_2939849
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL550 Ex: 550 nm, Em: 575 nm
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
