Product Info Summary
| SKU: | A02558 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-SESTRIN2 SESN2 Antibody
SKU/Catalog Number
A02558
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SESTRIN2 SESN2 Antibody (Catalog # A02558). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SESTRIN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-SESTRIN2 SESN2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02558)
Host
Rabbit
Contents
SESTRIN2 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SESTRIN2 antibody was raised against a 19 amino acid peptide near the center of human SESTRIN2. The immunogen is located within amino acids 220 - 270 of SESTRIN2.
Cross-reactivity
SESTRIN2 antibody is human, mouse and rat reactive. At least two isoforms of SESTRIN2 are known to exist; this antibody will detect both isoforms. SESTRIN2 antibody is predicted to not cross-react with SESTRIN1.
Reactive Species
A02558 is reactive to SESN2 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
54.5 kDa
Background of SESN2
SESTRIN2, also known as Hi95, is a member of the sestrin family of PA26-related proteins and is induced following DNA damage or oxidative stress (1). SESTRIN2 and the related protein SESTRIN1 interact with the NRF2 suppressor KEAP1, the autophagy substrate p62 and the ubiquitin ligase RBX1 to protect cells against oxidative stress by activating NRF2 and promoting the p62-dependent autophagic degradation of KEAP1 (2). SESTRIN2 also negatively regulates TOR signaling by activating AMP-activated protein kinase (AMPK) and TSC2 phosphorylation (3), thereby protecting cells against energetic stress-induced death (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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