| Short Description : | Rabbit polyclonal anti-Transient receptor potential cation channel subfamily V member 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
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| Immunogen: | Synthesized peptide derived from human VR1 |
| Specificity: | This antibody detects endogenous levels of VR1 at Human, Mouse, Rat |
| Post Translational Modifications | Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity. |
| Function | Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius. Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 1Trpv1Capsaicin ReceptorOsm-9-Like Trp Channel 1Otrpc1Vanilloid Receptor 1 |
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| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendritic Spine MembraneCell MembraneMostlyBut Not Exclusively Expressed In Postsynaptic Dendritic Spines |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 1 antibodyAnti-Trpv1 antibodyAnti-Capsaicin Receptor antibodyAnti-Osm-9-Like Trp Channel 1 antibodyAnti-Otrpc1 antibodyAnti-Vanilloid Receptor 1 antibodyAnti-TRPV1 antibodyAnti-VR1 antibody |
Information sourced from Uniprot.org