Bedaquiline [843663-66-1]
Referencia T2585-50mg
embalaje : 50mg
Marca : TargetMol
Bedaquiline
(Synonyms: TMC207, R207910) Copy Product Info
Bedaquiline (R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis.
Cas No. 843663-66-1
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Purity:99.96%
Color:White
COA LCMS HNMR
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Bedaquiline (R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis. |
| In vitro | Bedaquiline inhibits TDR M. tuberculosis strains with MIC values between 0.125 and 0.5 mg/L[1]. It shows the highest activity against Mycobacterium avium among slowly growing mycobacteria (SGM), with MIC50 and MIC90 values of 0.03 and 16 mg/L. Among rapidly growing mycobacteria (RGM), it is more effective against Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L. Bedaquiline also exhibits moderate in vitro activity against NTM species[2] and excellent in vitro activity against Mycobacterium tuberculosis, including multidrug-resistant strains[3]. |
| Synonyms | TMC207, R207910 |
| Molecular Weight | 555.50 |
| Formula | C32H31BrN2O2 |
| Cas No. | 843663-66-1 |
| Smiles | COC1=NC2=C(C=C(C=C2)Br)C=C1[C@@H](C3=CC=CC=C3)[C@](O)(C4=CC=CC5=C4C=CC=C5)CCN(C)C |
| Relative Density. | 1.322 g/cm3 |
| Storage | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.56 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||