Biotin-Linked Monoclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4)

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

SFRP4: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: cell surface; cytoplasm; extracellular space; integral component of membrane; nucleus

Molecular Function: G-protein coupled receptor activity; protein binding; Wnt-activated receptor activity; Wnt-protein binding

Biological Process: cell differentiation; G-protein coupled receptor signaling pathway; negative regulation of cell proliferation; negative regulation of transcription factor activity; negative regulation of Wnt signaling pathway; phosphate ion homeostasis; positive regulation of apoptosis; positive regulation of epidermal cell differentiation; positive regulation of receptor internalization; regulation of BMP signaling pathway; response to hormone

Disease: Pyle Disease