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Bobcat339 hydrochloride [2436747-44-1]

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Referencia T61012-100mg

embalaje : 100mg

Marca : TargetMol

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Bobcat339 hydrochloride

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Bobcat339 hydrochloride is a selective 10 11 translocation (TET) dioxygenase inhibitor that inhibits TET1 and TET2.Bobcat339 hydrochloride induces TET3 protein degradation and also stimulates the expression of AGRP, NPY, and VGAT in a TET3-dependent manner in mouse and human neuronal cells. VGAT expression, which can be used to study transient anorexia nervosa.

Cas No. 2436747-44-1

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Batch Information

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Purity:99.22%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Information

Bioactivity

Description	Bobcat339 hydrochloride is a selective 10 11 translocation (TET) dioxygenase inhibitor that inhibits TET1 and TET2.Bobcat339 hydrochloride induces TET3 protein degradation and also stimulates the expression of AGRP, NPY, and VGAT in a TET3-dependent manner in mouse and human neuronal cells. VGAT expression, which can be used to study transient anorexia nervosa.
Targets & IC50	TET2:73 μM, TET1:33 μM
In vitro	Bobcat339 hydrochloride is a potent and selective cytosine-based TET enzyme inhibitor, which significantly reduced the overall intracellular level of 5hmC by inhibiting TET enzyme activity in HT-22 cells at a concentration of 10 μM for 24 h. The IC₅₀ of Bobcat339 hydrochloride for TET1 and TET2 were 33 μM and 73 μM, respectively. ^[1]

Chemical Properties

Molecular Weight	334.2
Formula	C₁₆H₁₃Cl₂N₃O
Cas No.	2436747-44-1
Smiles	Cl.NC1=NC(=O)N(C=C1Cl)C1=CC=CC(=C1)C1=CC=CC=C1

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (299.22 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9922 mL	14.9611 mL	29.9222 mL	149.6110 mL
5 mM	0.5984 mL	2.9922 mL	5.9844 mL	29.9222 mL
10 mM	0.2992 mL	1.4961 mL	2.9922 mL	14.9611 mL
20 mM	0.1496 mL	0.7481 mL	1.4961 mL	7.4806 mL
50 mM	0.0598 mL	0.2992 mL	0.5984 mL	2.9922 mL
100 mM	0.0299 mL	0.1496 mL	0.2992 mL	1.4961 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.