Carrageenan

Biological Activity

Carrageenan is a biochemical reagent that can be used to construct animal models of chronic non-bacterial prostatitis, models of synovitis, and models of prostatitis.

Chemical Information

CAS Number	9000-07-1
Form	Solid
Storage	4°C, protect from light

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Barbara Borsani et al. Nutrients. The Role of Carrageenan in Inflammatory Bowel Diseases and Allergic Reactions: Where Do We Stand?

[2] Zhiwei Liu et al. Molecules. Anti-Cancer Activity of Porphyran and Carrageenan from Red Seaweeds

[3] Błażej B Błaszak et al. Acta Sci Pol Technol Aliment. Carrageenan as a functional additive in the production of cheese and cheese-like products

[4] Vipul D Prajapati et al. Carbohydr Polym. Carrageenan: a natural seaweed polysaccharide and its applications

[5] Liang Li et al. Carbohydr Polym. Carrageenan and its applications in drug delivery