FKBP51 antibody
Referencia orb147198-100ug
embalaje : 100ug
Marca : Biorbyt
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FKBP51 antibody
Catalog Number: orb147198
| Catalog Number | orb147198 |
|---|---|
| Category | Antibodies |
| Description | Mouse monoclonal to FKBP51 (PerCP). Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones. One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins. FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex. The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90. Although FKBP52 and FKBP51 share 75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics. FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids.. |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | Hi51B |
| Tested applications | ICC, WB |
| Reactivity | Canine, Hamster, Human, Mouse, Rabbit, Rat |
| Isotype | IgG1 |
| Immunogen | Synthetic peptide corresponding to the residues of human FKBP51 |
| Concentration | 1 mg/ml |
| Dilution range | WB (1:2000), ICC/IF (1:1000) |
| Conjugation | PerCP |
| MW | 51kDa |
| Target | FKBP51 |
| Entrez | 2289 |
| UniProt ID | Q13451 |
| NCBI | NP_001139247.1 |
| Storage | Conjugated antibodies should be stored at 4°C |
| Buffer/Preservatives | PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated |
| Alternative names | AIG6 antibody, FK506 binding protein 5 antibody, F |
| Note | For research use only |
| Application notes | A 1:2000 dilution was sufficient for detection of FKBP51 in ~50 µg total protein using WB analysis. |
| Expiration Date | 12 months from date of receipt. |