Calretinin is a calcium-binding protein that functions as a modulator of neuronal excitability and may play a protective role in the survival of nerve cells during disturbances in calcium homeostasis. It is abundantly expressed in subsets of neurons throughout the brain and spinal cord, particularly retina and sensory ganglia, but it is also found in mesothelium, eccrine sweat glands, Sertoli cells, ovarian stromal cells, and adrenal cortical cells. Due to its high sensitivity against mesothelial cells, calretinin is a useful marker in differentiating mesothelioma and metastatic adenocarcinoma to the serous membranes. It is also a diagnostic marker of Hirschsprung's disease and some ovarian and testicular cancers such as Sertoli-Leydig cell tumour, Sertoli cell tumour, Leydig cell tumour, sex cord tumour with annular tubules, and steroid cell tumour.

• IHC523-Calretinin Datasheet-IVD

• MSDS
• 2022 NordiQC Assessment Report for IHC523: Optimal

CLONE:
IHC523

ISOTYPE:
IgG1

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Mesothelioma, Appendix

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVD

ADDITIONAL INFORMATION:
NordiQC Rating: Optimal (Assessment Run 64 2022)