HRP-Linked Polyclonal Antibody to Podocin (PDCN)
Referencia MBS2049724-0,2mL
embalaje : 0.2mL
Marca : MyBiosource
Podocin (PDCN) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2049724SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
MBS2049724 is an antibody targeting PDCN. Also known as HRP-Linked Polyclonal Antibody to Podocin (PDCN). Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Podocin (PDCN), Polyclonal Antibody
Full Product Name
HRP-Linked Polyclonal Antibody to Podocin (PDCN)
Product Gene Name
anti-PDCN antibody
Product Synonym Names
NPHS2; NPHS-2; Nephrosis 2; Idiopathic Steroid-Resistant
Clonality
Polyclonal
Host
Rabbit
Form/Format
Liquid; Supplied as solution form in PBS, pH7.4, 50% glycerol 0.05% Proclin-300
Purity/Purification
Antigen-specific Affinity Chromatography
Concentration
0.62mg/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4°C for frequent use.
Aliquot and store at -20°C for 24 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Avoid repeated freeze/thaw cycles.
Store at 4°C for frequent use.
Aliquot and store at -20°C for 24 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: PDCN (MBS2004388)
HRP Conjugated Antibody: PDCN (MBS2049724)
HRP Conjugated Antibody: PDCN (MBS2049724)
Matching Pairs
HRP Conjugated Antibody: PDCN (MBS2049724)
Immunogen: PDCN (MBS2011029)
Immunogen: PDCN (MBS2011029)
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Antibody labeling
Label
HRP
Original Antibody
MBS2004388
Immunogen
Recombinant PDCN (Met222~Pro372) expressed in E.coli.
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-PDCN antibody
Western Blot (WB)
Application Notes for anti-PDCN antibody
Western blotting: 0.01-2ug/mL
Optimal working dilutions must be determined by end user
Optimal working dilutions must be determined by end user
Other Notes
Small volumes of anti-PDCN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for PDCN. It may not necessarily be applicable to this product.
NCBI Official Full Name
podocin
NCBI Official Synonym Full Names
NPHS2, podocin
NCBI Official Symbol
NPHS2
NCBI Official Synonym Symbols
PDCN; SRN1
UniProt Protein Name
Podocin
UniProt Gene Name
NPHS2
NCBI Protein Information
podocin
NCBI Summary for PDCN
This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for PDCN
NPHS2: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Defects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2). It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder. Belongs to the band 7/mec-2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: intercellular junction; lipid raft; plasma membrane; protein complex
Molecular Function: protein binding
Biological Process: actin cytoskeleton reorganization
Disease: Nephrotic Syndrome, Type 2
Show more Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: intercellular junction; lipid raft; plasma membrane; protein complex
Molecular Function: protein binding
Biological Process: actin cytoskeleton reorganization
Disease: Nephrotic Syndrome, Type 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-PDCN antibody
| Reference Product | PubMed Publications |
|---|---|
| CD2AP antibody | >61 publications with PDCN and CD2AP |
| TRPC6 antibody | >29 publications with PDCN and TRPC6 |
| KIRREL antibody | >8 publications with PDCN and KIRREL |
| FYN antibody | >2 publications with PDCN and FYN |
| KIRREL3 antibody | >1 publications with PDCN and KIRREL3 |
| GRB2 antibody | >1 publications with PDCN and GRB2 |
Diseases associated with anti-PDCN antibody
| Disease Name | Pubmed Publications |
|---|---|
| Kidney Diseases Antibodies | >369 publications with PDCN and Kidney Diseases |
| Nephrotic Syndrome Antibodies | >248 publications with PDCN and Nephrotic Syndrome |
| Proteinuria Antibodies | >234 publications with PDCN and Proteinuria |
| Nephrosis Antibodies | >215 publications with PDCN and Nephrosis |
| Glomerulosclerosis, Focal Segmental Antibodies | >141 publications with PDCN and Glomerulosclerosis, Focal Segmental |
| Renal Insufficiency Antibodies | >51 publications with PDCN and Renal Insufficiency |
| Albuminuria Antibodies | >49 publications with PDCN and Albuminuria |
| Kidney Failure, Chronic Antibodies | >42 publications with PDCN and Kidney Failure, Chronic |
| Hypertension Antibodies | >23 publications with PDCN and Hypertension |
| Nephrotic syndrome, idiopathic, steroid-resistant Antibodies | >21 publications with PDCN and Nephrotic syndrome, idiopathic, steroid-resistant |
Organs/Tissues associated with anti-PDCN antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Kidney Antibodies | >379 publications with PDCN and Kidney |