Hydroxychloroquine
Referencia M11408-100mg
embalaje : 100mg
Marca : AbMole Bioscience
Quality Control & Documentation
Biological Activity
Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection.
Product Citations
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J Sci Food Agric. 2023 May 1.
Oxymatrine ameliorates rheumatoid arthritis by regulation of Tfr/Tfh cells balance via TLR9-MyD88-STAT3 signaling pathway
Hydroxychloroquine purchased from AbMole
Chemical Information
Molecular Weight | 335.87 |
Formula | C18H26ClN3O |
CAS Number | 118-42-3 |
Storage | RT, protect from light, dry, sealed |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Akrithi Udupa, et al. Curr Allergy Asthma Rep. Hydroxychloroquine and COVID-19: a Rheumatologist's Take on the Lessons Learned
[2] Wesley H Self, et al. JAMA. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial
[3] Pankaj Bansal, et al. Ann Med. Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019
[4] Praveen Balabaskaran Nina, et al. Indian J Public Health. Hydroxychloroquine as prophylaxis or treatment for COVID-19: What does the evidence say?
[5] C Ponticelli, et al. Expert Opin Drug Saf. Hydroxychloroquine in systemic lupus erythematosus (SLE)