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Luliconazole [187164-19-8]

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Referencia NB-64-13375-50mg

embalaje : 50mg

Marca : Neo Biotech

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Luliconazole

(Synonyms: NND 502) Copy Product Info

Synonyms: NND 502

Catalog No. T2411 Copy Product Info

Purity: 99.83%

Luliconazole (NND 502) is an Azole Antifungal. The mechanism of action of luliconazole is as a Cytochrome P450 2C19 Inhibitor.

Cas No. 187164-19-8

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.83%

Appearance:Solid

Color:White

Product Introduction

Luliconazole AI Summary

Luliconazole exhibits a range of bioactivities, primarily serving as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies between 5956.9 nM and 33498.3 nM, in both the absence and presence of camptothecin (CPT). It also demonstrates antiviral properties, effectively blocking the entry of the Ebola virus with AC50 values between 39.81 µM to 39810.7 nM. In terms of SARS-CoV-2 inhibition, Luliconazole shows varying degrees of effectiveness; it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with a 14.33% inhibition rate at 10 µM concentration after 48 hours, and in VERO-6 cells, it shows a 0.62% inhibition rate under similar conditions. Additionally, the compound presented a hit score of 0.09705 for the inhibition of SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells and demonstrated a 7.07% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. It also showcases inhibitory activity against human HDAC6, with inhibition percentages of 17.84% and 1.21% in enzymatic assays using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Luliconazole (NND 502) is an Azole Antifungal. The mechanism of action of luliconazole is as a Cytochrome P450 2C19 Inhibitor.
In vitro	Luliconazole inhibits the growth of all filamentous fungi (except Saccharomyces cerevisiae) (MIC,≦0.004-0.125 μg/ml), Candida albicans (MIC range: 0.031-0.13 mg/ml), Trichophyton rubrum (MIC,≦0.00012-0.002 mg/ml).
In vivo	Luliconazole inhibits the growth of all filamentous fungi (except Saccharomyces cerevisiae) (MIC,≦0.004-0.125 μg/ml), Candida albicans (MIC range: 0.031-0.13 mg/ml), Trichophyton rubrum (MIC,≦0.00012-0.002 mg/ml).
Synonyms	NND 502

Chemical Properties

Molecular Weight	354.28
Formula	C₁₄H₉Cl₂N₃S₂
Cas No.	187164-19-8
Smiles	Clc1ccc([C@@H]2CS\C(S2)=C(\C#N)n2ccnc2)c(Cl)c1
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 166.67 mg/mL (470.45 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 5 mg/mL (14.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (28.23 mM), Solution.

10% DMSO+90% Saline: < 10 mg/mL (28.23 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8226 mL	14.1131 mL	28.2263 mL	141.1313 mL
5 mM	0.5645 mL	2.8226 mL	5.6453 mL	28.2263 mL
10 mM	0.2823 mL	1.4113 mL	2.8226 mL	14.1131 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1411 mL	0.7057 mL	1.4113 mL	7.0566 mL
50 mM	0.0565 mL	0.2823 mL	0.5645 mL	2.8226 mL
100 mM	0.0282 mL	0.1411 mL	0.2823 mL	1.4113 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

tinea pedistinea corporisskin infectionNND-502NND502LUZULuliconazoleInhibitorinhibitFungaldermatophytosisantifungalAntibiotic

Related Tags: Luliconazole chemical structure | Luliconazole in vivo | Luliconazole in vitro | Luliconazole formula | Luliconazole molecular weight