embalaje : 25mg
Synonyms:
| Description | MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, with IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α. This compound impairs MAO A activity, disrupts HSP90 binding, and downregulates HER2 and phospho-Akt expressions, thus inhibiting GBM growth. Additionally, it reduces PD-L1 expression, thwarting T cell activation and potential tumor immune evasion. MAO A/HSP90-IN-1 (4-b) is valuable for research into brain tumor-related diseases [1]. |
| Targets & IC50 | HSP90:0.019 μM, MAO-A:1.77 μM |
| In vitro | MAO A/HSP90-IN-1 (4-b) inhibits GBM cell proliferation by suppressing MAO A and HSP90 at concentrations of 0.1-3 μM over 24 hours [1]. It showed an IC50 of 0.73 μM and 1.68 μM in different GL26 trials and 0.84 μM in U251R cells [1]. At 0, 0.35, 0.7, and 1.4 μM, it also reduced IFN-γ-induced PD-L1 expression in murine glioma GL26 cells after 24 hours [1]. |
| In vivo | MAO A/HSP90-IN-1 (4-b) (25 mg/kg, intraperitoneal injection, daily) suppresses tumor growth in a murine GBM model [1]. |
| Molecular Weight | 444.95 |
| Formula | C24H29ClN2O4 |
| Cas No. | 2927489-95-8 |
| Smiles | C(N(C)C1=CC(Cl)=C(OCCCN(CC#C)C)C=C1)(=O)C2=CC(C(C)C)=C(O)C=C2O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
| Size | Quantity | Unit Price | Amount | Operation |
|---|
