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Prostaglandin E3 [802-31-3]

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Referencia NB-64-25934-500ug

embalaje : 500ug

Marca : Neo Biotech

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Prostaglandin E3 (Synonyms: PGE3)

Catalog No. T38194 Copy Product Info

Purity: 98%

Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, inhibits polarization to M1 macrophages, and shows anti-proliferative effects in human lung cancer cells.

Prostaglandin E3

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Synonyms PGE3

Cas No. 802-31-3

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Purity:98%

Appearance:Liquid

Color:Transparent

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Product Introduction

Bioactivity

Description	Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, inhibits polarization to M1 macrophages, and shows anti-proliferative effects in human lung cancer cells.
In vitro	METHODS: To investigate the role of Prostaglandin E3 in modulating macrophage polarization, THP-1 cells (a human monocytic cell line) were used to induce macrophage polarization, and the effects of different concentrations of Prostaglandin E3 on the markers of M1 and M2 macrophages were observed. RESULTS: Prostaglandin E3 (1-10000 nM) was found to inhibit the expression of M1 macrophage markers while promoting the polarization towards M2 macrophages[1].
In vivo	METHODS: To investigate the effect of Prostaglandin E3 on the proliferation of prostate tumor cells, prostate tumor cells were injected into mice, and Prostaglandin E3 was continuously administered during the experiment to observe the growth of the tumors and the infiltration of macrophages. RESULTS: Continuous injection of Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) significantly reduced the weight of the transplanted tumors and decreased the expression of CD68 and CD206 (markers of M2 macrophages) within the tumors[1].
Synonyms	PGE3

Chemical Properties

Molecular Weight	350.45
Formula	C₂₀H₃₀O₅
Cas No.	802-31-3
Smiles	C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](C/C=C\CC)O)[C@H](O)CC1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (85.6 mM), Sonication is recommended.

DMF: 30 mg/mL (85.6 mM), Sonication is recommended.

Ethanol: 30 mg/mL (85.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8535 mL	14.2674 mL	28.5347 mL	142.6737 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL	28.5347 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL	14.2674 mL
20 mM	0.1427 mL	0.7134 mL	1.4267 mL	7.1337 mL
50 mM	0.0571 mL	0.2853 mL	0.5707 mL	2.8535 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.