Recombinant Human Growth Hormone (E. coli)

Biological Activity

Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors. It plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH includes prolactin, placental lactogens, proliferins, and somatolactin. It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretory granules. It stimulates both the differentiation and proliferation of myoblasts.

Recombinant Human Growth Hormone expressed the target gene encoding Phe27-Phe217.

Accession: P01241

Apparent Molecular Weight: 20 KDa, reducing conditions

Endotoxin < 1 EU/µg

Lyophilized from a 0.2 μm filtered solution of 20mM HEPES-NaOH, 8% Trehalose，2% Mannitol, 0.05% Tween80, pH 7.0.

Chemical Information

Form	Lyophilized powder
Solubility (25°C)	Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL.
Storage	Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.

References

[1] No authors listed. Aust Prescr. Somatrogon for growth hormone deficiency

[2] Yvette N Lamb. Somatrogon: First Approval

[3] Salam Ranabir, et al. Indian J Endocrinol Metab. Stress and hormones

[4] A Takeda, et al. Health Technol Assess. Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation

[5] Binder G, et al. Horm Res. Genetics and Responsiveness to Growth Hormone Therapy