Recombinant Mouse Interleukin-1 receptor-associated kinase 4 (Irak4)
Referencia MBS1292509-0,02mg-E
embalaje : 0.02mg(E-Coli)
Marca : MyBiosource
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Mouse Recombinant Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1292509MBS1292509 is a recombinant protein targeting Irak4. Also known as Recombinant Mouse Interleukin-1 receptor-associated kinase 4 (Irak4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details
Product Overview
Online Datasheet in PDFProduct Name
Interleukin-1 receptor-associated kinase 4 (Irak4), Recombinant Protein
Full Product Name
Recombinant Mouse Interleukin-1 receptor-associated kinase 4 (Irak4)
Product Gene Name
Irak4 recombinant protein
Product Synonym Gene Name
Irak4
Sequence
MNKPLTPSTY IRNLNVGILR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ FHIRRFEALL QTGKSPTCEL LFDWGTTNCT VGDLVDLLVQ IELFAPATLL LPDAVPQTVK SLPPREAATV AQTHGPCQEK DRTSVMPMPK LEHSCEPPDS SSPDNRSVES SDTRFHSFSF HELKSITNNF DEQPASAGGN RMGEGGFGVV YKGCVNNTIV AVKKLGAMVE ISTEELKQQF DQEIKVMATC QHENLVELLG FSSDSDNLCL VYAYMPNGSL LDRLSCLDGT PPLSWHTRCK VAQGTANGIR FLHENHHIHR DIKSANILLD KDFTAKISDF GLARASARLA QTVMTSRIVG TTAYMAPEAL RGEITPKSDI YSFGVVLLEL ITGLAAVDEN REPQLLLDIK EEIEDEEKTI EDYTDEKMSD ADPASVEAMY SAASQCLHEK KNRRPDIAKV QQLLQEMSA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
50,872 Da
Sequence Positions
Expression Region: 1-459aa; Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of Irak4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for Irak4. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-1 receptor-associated kinase 4
NCBI Official Synonym Full Names
interleukin-1 receptor-associated kinase 4
NCBI Official Symbol
Irak4
NCBI Official Synonym Symbols
IRAK-4; NY-REN-64; 8430405M07Rik; 9330209D03Rik
UniProt Protein Name
Interleukin-1 receptor-associated kinase 4
Protein Family
Interleukin-1 receptor-associated kinase
UniProt Gene Name
Irak4
UniProt Synonym Gene Names
IRAK-4
NCBI Protein Information
interleukin-1 receptor-associated kinase 4
UniProt Comments for Irak4
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections ().
Show more Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with Irak4 recombinant protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
| Apoptosis Signaling Pathway antibodies | Apoptosis Signaling Pathway Diagram |
| Chagas Disease (American Trypanosomiasis) Pathway antibodies | Chagas Disease (American Trypanosomiasis) Pathway Diagram |
| Chagas Disease (American Trypanosomiasis) Pathway antibodies | Chagas Disease (American Trypanosomiasis) Pathway Diagram |
| IL-1 Signaling Pathway antibodies | IL-1 Signaling Pathway Diagram |
| Immune System Pathway antibodies | Immune System Pathway Diagram |
| Influenza A Pathway antibodies | Influenza A Pathway Diagram |
| Influenza A Pathway antibodies | Influenza A Pathway Diagram |
| Innate Immune System Pathway antibodies | Innate Immune System Pathway Diagram |
Diseases associated with Irak4 recombinant protein
| Disease Name | Pubmed Publications |
|---|---|
| IRAK4 DEFICIENCY Antibodies | >47 publications with Irak4 and IRAK4 DEFICIENCY |
| Inflammation Antibodies | >37 publications with Irak4 and Inflammation |
| Necrosis Antibodies | >31 publications with Irak4 and Necrosis |
| Death Antibodies | >23 publications with Irak4 and Death |
| Disease Models, Animal Antibodies | >5 publications with Irak4 and Disease Models, Animal |
| Drug Toxicity Antibodies | >3 publications with Irak4 and Drug Toxicity |
| Adenocarcinoma Antibodies | >2 publications with Irak4 and Adenocarcinoma |
| Nerve Degeneration Antibodies | >1 publications with Irak4 and Nerve Degeneration |
| Hypertension Antibodies | >1 publications with Irak4 and Hypertension |
| Ovarian Neoplasms Antibodies | >1 publications with Irak4 and Ovarian Neoplasms |
Organs/Tissues associated with Irak4 recombinant protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Bone Marrow Antibodies | >9 publications with Irak4 and Bone Marrow |
| Lung Antibodies | >8 publications with Irak4 and Lung |
| Brain Antibodies | >6 publications with Irak4 and Brain |
| Kidney Antibodies | >5 publications with Irak4 and Kidney |
| Skin Antibodies | >5 publications with Irak4 and Skin |
| Spleen Antibodies | >4 publications with Irak4 and Spleen |
| Prostate Antibodies | >3 publications with Irak4 and Prostate |
| Thymus Antibodies | >1 publications with Irak4 and Thymus |
| Embryonic Tissue Antibodies | >1 publications with Irak4 and Embryonic Tissue |
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Referencia
Descripción
Cond.
Precio Sin IVA
MBS1292509-0,1mg-E
0.1mg(E-Coli)
MBS1292509-0,02mg-B
0.02mg(Baculovirus)