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S1H TFA

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Referencia NB-64-44287-5mg

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Marca : Neo Biotech


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S1H TFA

(Synonyms: Site 1-binding Helix) Copy Product Info

Synonyms: Site 1-binding Helix

Catalog No. T83756 Copy Product Info
S1H, a synthetic peptide mimetic of human growth hormone amino acids 36-51, acts as an antagonist to the growth hormone receptor. It forms an α-helical structure in solution and inhibits STAT5 phosphorylation triggered by human growth hormone in SK-MEL-28 and MALME-3M melanoma cell lines, as well as prolactin in IM-9 B cell lymphocytes, at concentrations of 100 and 200 nM.
Other Forms of S1H TFA:
S1HTP3539
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For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Description
S1H, a synthetic peptide mimetic of human growth hormone amino acids 36-51, acts as an antagonist to the growth hormone receptor. It forms an α-helical structure in solution and inhibits STAT5 phosphorylation triggered by human growth hormone in SK-MEL-28 and MALME-3M melanoma cell lines, as well as prolactin in IM-9 B cell lymphocytes, at concentrations of 100 and 200 nM.
SynonymsSite 1-binding Helix
Chemical Properties
Molecular Weight2025.30
FormulaC94H141N23O27.XCF3COOH
SmilesNC([C@@]([C@@H](C)O)(14)NC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@@H]2CCCN2C([C@@]([C@H](CC)C)(14)NC([C@@H](NC(C)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
SequenceAc-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-Leu-Gln-Asn-Pro-Gln-Thr-NH₂
Sequence ShortYIPKEQKYSFLQNPQT
Storage & Solubility Information
StorageKeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Related Tags: S1H TFA chemical structure | S1H TFA formula | S1H TFA molecular weight