- More Files
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SQSTM1 is approximately 0.03ng/ml as a capture antibody.
Immunofluorescence
Immunofluorescence of monoclonal antibody to SQSTM1 on HeLa cell. [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (74.14 KDa) .
- Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant SQSTM1.
Immunogen
SQSTM1 (AAH03139.1, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (90); Rat (90)
Isotype
IgG2a kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (74.14 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SQSTM1 is approximately 0.03ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to SQSTM1 on HeLa cell. [antibody concentration 10 ug/ml] - Gene Info — SQSTM1
Entrez GeneID
8878GeneBank Accession#
BC003139Protein Accession#
AAH03139.1Gene Name
SQSTM1
Gene Alias
A170, OSIL, PDB3, ZIP3, p60, p62, p62B
Gene Description
sequestosome 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq
Other Designations
EBI3-associated protein p60|Paget disease of bone 3|oxidative stress induced like|phosphotyrosine independent ligand for the Lck SH2 domain p62|ubiquitin-binding protein p62
- Interactome
- Disease
- Publication Reference
- NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
Swagatika Paul, Shireen A Sarraf, Ki Hong Nam, Leila Zavar, Nicole DeFoor, Sahitya Ranjan Biswas, Lauren E Fritsch, Tomer M Yaron, Jared L Johnson, Emily M Huntsman, Lewis C Cantley, Alban Ordureau, Alicia M Pickrell.
The Journal of Cell Biology 2024 Feb; 223(2):e202303082.
Application：WB, Human, HeLa cells.
- Uric Acid Mitigates Cognitive Deficits via TFEB-Mediated Microglial Autophagy in Mice Models of Alzheimer's Disease.
Qian Xiao, Jiaojiao Wang, Qiuyun Tian, Na Tian, Qi Tian, Xin He, Yutian Wang, Zhifang Dong.
Molecular Neurobiology 2023 Nov; Epub:0.
Application：WB, Mouse, Mouse Microglia BV2 cells.
- Functional characterization of the CRY2 circadian clock component variant p.Ser420Phe revealed a new degradation pathway for CRY2.
Gizem Cagla Parlak, Ibrahim Baris, Seref Gul, Ibrahim Halil Kavakli.
The Journal of Biological Chemistry 2023 Nov; 299(12):105451.
Application：WB, Human, HEK293T cells.
- Melatonin Alleviates the Impairment of Muscle Bioenergetics and Protein Quality Control Systems in Leptin-Deficiency-Induced Obesity.
Yaiza Potes, Andrea Díaz-Luis, Juan C Bermejo-Millo, Zulema Pérez-Martínez, Beatriz de Luxán-Delgado, Adrian Rubio-González, Iván Menéndez-Valle, José Gutiérrez-Rodríguez, Juan J Solano, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes.
Antioxidants 2023 Nov; 12(11):1962.
Application：WB, Mice, Mouse skeletal muscle.
- C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy.
Shen Zhang, Mindan Tong, Denghao Zheng, Huiying Huang, Linsen Li, Christian Ungermann, Yi Pan, Hanyan Luo, Ming Lei, Zaiming Tang, Wan Fu, She Chen, Xiaoxia Liu, Qing Zhong.
Nature Communications 2023 Oct; 14(1):6360.
Application：WB, Human, HEK293T, U2OS cells.
- Bacteroides fragilis Enterotoxin Induces Autophagy through an AMPK and FoxO3-Pathway, Leading to the Inhibition of Apoptosis in Intestinal Epithelial Cells.
Su Hyuk Ko, Jun Ho Choi, Jung Mogg Kim.
Toxins 2023 Sep; 15(9):544.
Application：IF, WB, Human, HCT116 cells.
- An autophagy-inducing stapled peptide induces mitochondria dysfunction and triggers autotic cell death in triple-negative breast cancer.
Xiaozhe Zhang, Gao Shan, Na Li, Jingyi Chen, Changyang Ji, Xiaoxiao Li, Liwen Jiang, Terence Kin Wah Lee, Vincent W Keng, Yanxiang Zhao.
Cell Death Discovery 2023 Aug; 9(1):303.
Application：WB, Human, BT549, MDA-MB-231, MDA-MB-468 cells.
- Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation.
Tian-Tian Wang, Li-Chun Zhang, Zhen Qin, Shu-Jun Chen, Jing-Min Zeng, Jing-Yan Li, Lin An, Cai-Yan Wang, Yong Gao, Li-Ming Wang, Zhong-Xiang Zhao, Zhong-Qiu Liu, Shao-Gui Wang.
Acta Pharmacologica Sinica 2023 Aug; [Epub].
Application：IF, WB, Human, Mouse, AR42J cells, Mouse pancrease.
- Cathepsin D overexpression in the nervous system rescues lethality and A β 42 accumulation of cathepsin D systemic knockout in vivo.
Xiaosen Ouyang, Willayat Y Wani, Gloria A Benavides, Matthew J Redmann, Hai Vo, Thomas van Groen, Victor M Darley-Usmar, Jianhua Zhang.
Acta Pharmaceutica Sinica. B 2023 Oct; 13(10):4172.
Application：WB, Mouse, Mouse brain cortex.
- Analysis of ATG4C function in vivo.
Isaac Tamargo-Gómez, Gemma G Martínez-García, María F Suárez, Pablo Mayoral, Gabriel Bretones, Aurora Astudillo, Jesús Prieto-Lloret, Christina Sveen, Antonio Fueyo, Nikolai Engedal, Carlos López-Otín, Guillermo Mariño
Autophagy 2023 Nov; 19(11):2912.
Application：WB, Mouse, MEFs, Mouse brain, Mouse Diaphragm, Mouse heart, Mouse kidney, Mouse liver, Mouse lung, Mouse skeletal muscle, Mouse spleen, Mouse thymus.
- Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis.
Chantal Alkhoury, Nathaniel F Henneman, Volodymyr Petrenko, Yui Shibayama, Arianna Segaloni, Alexis Gadault, Ivan Nemazanyy, Edouard Le Guillou, Amare Desalegn Wolide, Konstantina Antoniadou, Xin Tong, Teruya Tamaru, Takeaki Ozawa, Muriel Girard, Karim Hnia, Dominik Lutter, Charna Dibner, Ganna Panasyuk.
Nature Cell Biology 2023 Jul; 25(7):975.
Application：IF, WB, Mouse, MEF, Mouse liver.
- Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation.
Alessia Calcagni', Leopoldo Staiano, Nicolina Zampelli, Nadia Minopoli, Niculin J Herz, Giuseppe Di Tullio, Tuong Huynh, Jlenia Monfregola, Alessandra Esposito, Carmine Cirillo, Aleksandar Bajic, Mahla Zahabiyon, Rachel Curnock, Elena Polishchuk, Luke Parkitny, Diego Luis Medina, Nunzia Pastore, Peter J Cullen, Giancarlo Parenti, Maria Antonietta De Matteis, Paolo Grumati, Andrea Ballabio.
Nature Communications 2023 Jul; 14(1):3911.
Application：WB, Human, N/A.
- Neratinib is a TFEB and TFE3 activator that potentiates autophagy and unbalances energy metabolism in ERBB2+ breast cancer cells.
Grazia Bellese, Erica Tagliatti, Maria Cristina Gagliani, Sara Santamaria, Pietro Arnaldi, Paola Falletta, Paola Rusmini, Michela Matteoli, Patrizio Castagnola, Katia Cortese.
Biochemical Pharmacology 2023 Jul; 213:115633.
Application：WB, Human, SKBR-3 cells.
- Coronaviral ORF6 protein mediates inter-organelle contacts and modulates host cell lipid flux for virus production.
Mengzhen Yue, Bing Hu, Jiajia Li, Ruifeng Chen, Zhen Yuan, Hurong Xiao, Haishuang Chang, Yaming Jiu, Kun Cai, Binbin Ding.
The EMBO Journal 2023 Jul; 42(13):e112542.
Application：WB-Ce, Human, Monkey, HEK293T, HeLa, Vero-E6, COS7 cells.
- Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex.
Reo Kurusu, Yuki Fujimoto, Hideaki Morishita, Daisuke Noshiro, Shuhei Takada, Koji Yamano, Hideaki Tanaka, Ritsuko Arai, Shun Kageyama, Tomoko Funakoshi, Satoko Komatsu-Hirota, Hikari Taka, Saiko Kazuno, Yoshiki Miura, Masato Koike, Toshifumi Wakai, Satoshi Waguri, Nobuo N Noda, Masaaki Komatsu.
Developmental Cell 2023 Jul; 58(13):1189.
Application：IEM, Human, Hul-1 cells.
- Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity.
Jianbin Wen, Andreas Zellner, Nils Christian Braun, Thomas Bajaj, Nils Christian Gassen, Michael Peitz, Oliver Brüstle.
Translational Psychiatry 2023 May; 13(1):143.
Application：WB, Human, Pluripotent stem cells.
- Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer.
Subhadip Mukhopadhyay, Joel Encarnación-Rosado, Elaine Y Lin, Albert S W Sohn, Huan Zhang, Joseph D Mancias, Alec C Kimmelman.
Science Advances 2023 Apr; 9(16):eadf9284.
Application：WB-Ce, Human, A498, HCT116, PDAC cells.
- STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.
Tracy L Hagemann, Sierra Coyne, Alder Levin, Liqun Wang, Mel B Feany, Albee Messing.
Cells 2023 Mar; 12(7):978.
Application：IF, Mouse, Mouse hippocampus.
- Conditioned Media from Head and Neck Cancer Cell Lines and Serum Samples from Head and Neck Cancer Patients Drive Catabolic Pathways in Cultured Muscle Cells.
Nicolas Saroul, Nicolas Tardif, Bruno Pereira, Alexis Dissard, Laura Montrieul, Phelipe Sanchez, Jérôme Salles, Jens Erik Petersen, Towe Jakobson, Laurent Gilain, Thierry Mom, Yves Boirie, Olav Rooyakers, Stéphane Walrand.
Cancers 2023 Mar; 15(6):1843.
Application：WB-Ce, Human, UT-SCC-60A, UT-SCC-5 cells..
- Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication.
Xuan Tan, Kun Cai, Jiajia Li, Zhen Yuan, Ruifeng Chen, Hurong Xiao, Chuanrui Xu, Bing Hu, Yali Qin, Binbin Ding.
Cell Reports 2023 Mar; 42(4):112286.
Application：WB-Ce, Human, Monkey, HeLa, HKE293T, Vero-E6 cells.
- TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
François Le Guerroué, Eric N Bunker, William M Rosencrans, Jack T Nguyen, Mohammed A Basar, Achim Werner, Tsui-Fen Chou, Chunxin Wang, Richard J Youle.
Molecular Cell 2023 Mar; 83(6):927.
Application：WB-Ce, Human, HeLa cells.
- Modifying Dietary Protein Impacts mTOR Signaling and Brain Deposition of Amyloid β in a Knock-In Mouse Model of Alzheimer Disease.
Julien Bensalem, Leanne K Hein, Sofia Hassiotis, Paul J Trim, Christopher G Proud, Leonie K Heilbronn, Timothy J Sargeant.
The Journal of Nutrition 2023 Mar; 153(5):1407.
Application：WB-Ti, Mouse , Mouse brain.
- Parallel Neurodegenerative Phenotypes in Sporadic Parkinson's Disease Fibroblasts and Midbrain Dopamine Neurons.
M J Corenblum, A McRobbie-Johnson, E Carruth, K Bernard, M Luo, L J Mandarino, S Peterson, D Billheimer, T Maley, E D Eggers, L Madhavan
bioRxiv : the Preprint Server for Biology 2023 Feb; 2023.02.10.527867.
Application：WB-Ce, WB-Ti, Human, Human fibroblast, Induced pluripotent stem cells.
- ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy.
Pablo Sánchez-Martín, Franziska Kriegenburg, Ludovico Alves, Julius Adam, Jana Elsaesser, Riccardo Babic, Hector Mancilla, Mariya Licheva, Georg Tascher, Christian Münch, Stefan Eimer, Claudine Kraft.
Journal of Cell Science 2023 Feb; 136(3):jcs260546.
Application：WB-Tr, Human, HKE293T cells.
- Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-induced Liver Injury in Aged Mice.
Hui Qian, Xiaojuan Chao, Shaogui Wang, Yuan Li, Xiaoxiao Jiang, Zhaoli Sun, Thomas Rülicke, Kurt Zatloukal , Hong-Min Ni , Wen-Xing Ding.
Cellular and Molecular Gastroenterology and Hepatology 2023 Feb; 15(5):1027.
Application：WB-Ti, IF, IHC-P, Human, Mouse, Human liver, mouse liver.
- In-Cell Chemical Crosslinking Identifies Hotspots for SQSTM-1/p62-IκBα Interaction That Underscore a Critical Role of p62 in Limiting NF-κB Activation Through IκBα Stabilization.
Yi Liu, Michael J Trnka, Liang He, A L Burlingame, Maria Almira Correia.
Molecular & Cellular proteomics: MCP 2023 Feb; 22(2):100495.
Application：WB, Mouse, Hepatocyte, HepG2, MEFs.
- Tamoxifen improves muscle structure and function of Bin1- and Dnm2-related centronuclear myopathies.
Charlotte Gineste, Alix Simon, Marie Braun, David Reiss, Jocelyn Laporte.
Brain 2022 Dec; [Epub].
Application：WB-Ti, Mouse, Mouse muscle.
- SNAP23 is essential for germination of EV-D68 replication organelles.
Katelyn Miller, Michael A Wagner, Alagie Jassey, William T Jackson.
Virology 2023 Jan; 578:117.
Application：WB, Human, H1HeLa cells.
- Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome-lysosome fusion.
Yunash Maharjan, Raghbendra Kumar Dutta, Jinbae Son, Xiaofan Wei, Channy Park, Hyug Moo Kwon, Raekil Park.
Cell Communication and Signaling 2022 Nov; 20(1):189.
Application：WB-Ce, Human, Mouse, MEF, RPE1 cells .
- Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue.
Caitlin S Latimer, Erica J Melief, Jeanelle Ariza-Torres, Kim Howard, Amanda R Keen, Lisa M Keene, Aimee M Schantz, Trevor M Sytsma, Angela M Wilson, Thomas J Grabowski, Martin Darvas, Kristen Dams O'Connor, Amber L Nolan, Brian L Edlow, Christine L Mac Donald, C Dirk Keene.
Methods in Molecular Biology (Clifton, N.J.) 2022 Nov; 2561:3.
Application：IHC-P, Human, Human brain.
- A Beclin 1-targeting stapled peptide synergizes with erlotinib to potently inhibit proliferation of non-small-cell lung cancer cells.
Jingyi Chen, Xiaozhe Zhang, Shan Gao, Na Li, Vincent Keng, Yanxiang Zhao.
Biochemical and Biophysical Research Communications 2022 Oct; 636(Pt 1):125.
Application：WB, Human, A549, H1975 cells.
- Development of new tools to study membrane-anchored mammalian Atg8 proteins.
Sang-Won Park, Pureum Jeon, Akinori Yamasaki, Hye Eun Lee, Haneul Choi, Ji Young Mun, Yong-Woo Jun, Ju-Hui Park, Seung-Hwan Lee, Soo-Kyeong Lee, You-Kyung Lee, Hyun Kyu Song, Michael Lazarou, Dong-Hyong Cho, Masaaki Komatsu, Nobuo N. Noda, Deok-Jin Jang, Jin-A Lee.
Autophagy 2022 Oct; 1:20.
Application：WB-Ce, Human, HEK293T cells.
- Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Yun Seok Kim, Bongsub Ko, Da Jung Kim, Jihoon Tak, Chang Yeob Han, Joo-Youn Cho, Won Kim, Sang Geon Kim.
Nature Communications 2022 Oct; 13(1):6080.
Application：WB-Ce, Human, Mouse, AML-12, Human hepatocyte, mouse liver.
- Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology.
Alba Navarro-Romero, Irene Fernandez-Gonzalez, Jordi Riera, Marta Montpeyo, Merce Albert-Bayo, Tresa Lopez-Royo, Pablo Castillo-Sanchez, Clara Carnicer-Caceres, Jose Antonio Arranz-Amo, Laura Castillo-Ribelles, Eddie Pradas, Josefina Casas, Miquel Vila, Marta Martinez-Vicente.
NPJ Parkinson's Disease 2022 Oct; 8(1):126.
Application：WB-Ce, Human, BE(2)-M17 cells.
- Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle.
Nirajan Neupane, Jayasimman Rajendran, Jouni Kvist, Sandra Harjuhaahto, Bowen Hu, Veijo Kinnunen, Yang Yang, Anni I Nieminen, Henna Tyynismaa.
Communications Biology 2022 Oct; 5(1):1060.
Application：WB-Ce, Mouse, Mouse skeletal muscle.
- OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy.
Sofia Ahola, Pablo Rivera Mejías, Steffen Hermans, Srikanth Chandragiri, Patrick Giavalisco, Hendrik Nolte, Thomas Langer.
Cell Metabolism 2022 Sep; S1550-4131(22):00360-6.
Application：WB-Ce, Mouse, Mouse heart.
- Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus.
Ozan Baytas, Julie A Kauer, Eric M Morrow.
Neurobiology of Disease 2022 Jul; 105831:0.
Application：IF, Mouse, Brain tissue.
- Prolonged proteasome inhibition antagonizes TGFβ1-dependent signalling by promoting the lysosomal-targeting of TGFβ receptors.
Charles B Trelford, Gianni M Di Guglielmo.
Cellular Signalling 2022 Oct; 98:110414.
Application：IF, WB-Ce, Human, A549 cells.
- Efficacy of stem cell-based therapies for colistin-induced nephrotoxicity.
Özlem Öz Gergin, Sibel Seckin Pehlivan, Menekse Ulger, Ozge Cengiz Mat, Adnan Bayram, Zeynep Burçin Gönen, Nur Seda Gökdemir, Cihangir Biçer, Karamehmet Yildiz, Arzu Hanım Yay.
Environmental Toxicology and Pharmacology 2022 Aug; 94:103933.
Application：IHC, Rat.
- Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.
Xiaowen Ma, Allen Chen, Luma Melo, Ana Clemente-Sanchez, Xiaojuan Chao, Ali Reza Ahmadi, Brandon Peiffer, Zhaoli Sun, Hiromi Sesaki, Tiangang Li, Xiaokun Wang, Wanqing Liu, Ramon Bataller, Hong-Min Ni, Wen-Xing Ding
Hepatology 2022 Jul; 77(1):159.
Application：WB, Mouse, Mouse liver.
- Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1.
Bojana Kravić, Tihana Bionda, Alexander Siebert, Pinki Gahlot, Sophie Levantovsky, Christian Behrends, Hemmo Meyer.
Molecular Cell 2022 Jun; 82(14):2633.
Application：IF, Human, HeLa cells.
- The role of autophagy in cadmium-induced acute toxicity in glomerular mesangial cells and tracking polyubiquitination of cytoplasmic p53 as a biomarker.
Ki-Tae Jung and Seon-Hee Oh.
Experimental & Molecular Medicine 2022 May; 54(5):685.
Application：IF, Mouse, MES13e cells.
- A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress.
Sinem Demirbag-Sarikaya, Yunus Akkoc, Sıla Turgut, Secil Erbil-Bilir, Nur Mehpare Kocaturk, Joern Dengjel, Devrim Gozuacik.
Scientific Reports 2022 May; 12(1):8134.
Application：IF-Tr, Human, HeLa cells.
- A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux.
Xiao Xiao, Philip. E.D. Chung, Mei Xu, Anling Hu, Yangju Ju, Xinmei Yang, Jialei Song, Jinrui Song, Chunlin Wang, Eldad Zacksenhaus, Sheng Liu, Zhixu He, Yaacov Ben-David.
Biochemical Pharmacology 2022 May; 201:115060.
Application：WB, Human, MDA-MB-231 cells.
- Starvation after infection restricts enterovirus D68 replication.
Alagie Jassey, Michael A Wagner, Ganna Galitska, Bimal Paudel, Katelyn Miller, William T Jackson.
Autophagy 2023 Jan; 19(1):112.
Application：WB-Ce, Human, A549, H1HeLa, SH-SY5Y cells.
- Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the Liver.
Nazmul Huda, Bilon Khambu, Gang Liu, Hirokazu Nakatsumi, Shengmin Yan, Xiaoyun Chen, Michelle Ma, Zheng Dong, Keiichi I Nakayama, Xiao-Ming Yin.
Cellular and Molecular Gastroenterology and Hepatology 2022 Apr; 14(2):333.
Application：WB-Ce, Mouse, Mouse liver.
- Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer.
Xiaopeng Xiong, Sumati Hasani, Lyndsay E A Young, Dylan R Rivas, Ashley T Skaggs, Rebecca Martinez, Chi Wang, Heidi L Weiss, Matthew S Gentry, Ramon C Sun, Tianyan Gao.
Cell Death and Differentiation 2022 Oct; 29(10):1913.
Application：IP, WB, Human, PT130 cells.
- Free fatty acid treatment of mouse preimplantation embryos demonstrates contrasting effects of palmitic acid and oleic acid on autophagy.
Zuleika C L Leung, Basim Abu Rafea, Andrew J Watson, Dean H Betts.
American Journal of Physiology. Cell Physiology 2022 May; 322(5):C833.
Application：IF, Mouse, Embryo.
- Acute inhibition of OGA sex-dependently alters the networks associated with bioenergetics, autophagy, and neurodegeneration.
Van N Huynh, Gloria A Benavides, Michelle S Johnson, Xiaosen Ouyang, Balu K Chacko, Edie Osuma, Toni Mueller, John Chatham, Victor M Darley-Usmar, Jianhua Zhang.
Molecular Brain 2022 Mar; 15(1):22.
Application：WB-Ti, Mouse, Mouse cortex.
- PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway.
Da Hyun Lee, Jeong Su Park, Yu Seol Lee, Soo Han Bae.
Redox Biology 2022 Apr; 50:102235.
Application：WB-Ce, WB-Tr, Mouse, Hepa-1c1c7 cells, Mouse embrynoic fibroblasts, Mouse liver.
- Adenovirus vector encoding TPPII ignites HBV-specific CTL response by activating autophagy in CD8+T cell.
Quanhui Tan, Jie Chen, Gao Gao, Yizhang, Xiaohua Chen, Yongsheng Yu, Guoqin Zang, Zhenghao Tang.
Journal of Viral Hepatitis 2022 Mar; 29(3):178.
Application：IP, Human, Human lymphocyte.
- Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice.
Hui Qian, Qingyun Bai, Xiao Yang, Jephte Y Akakpo, Lili Ji, Li Yang, Thomas Rülicke, Kurt Zatloukal, Hartmut Jaeschke, Hong-Min Ni, Wen-Xing Ding.
Acta Pharmaceutica Sinica. B 2021 Dec; 11(12):3791.
Application：WB-Ce, Mouse, Mouse liver.
- Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy.
Sabine Weisheit, Catherine S Wegner, Ieva Ailte, Maja Radulovic, Anette Weyergang, Pål Kristian Selbo, Andreas Brech.
Biochemical Pharmacology 2021 Dec; 194:114837.
Application：IF, Human, MA-11 cells.
- P62 accumulates through neuroanatomical circuits in response to tauopathy propagation.
François-Xavier Blaudin de Thé, Benjamin Lassus, Ari W Schaler, Stephanie L Fowler, Chris N Goulbourne, Ross Jeggo, Clotilde Mannoury la Cour, Mark J Millan, Karen E Duff.
Acta Neuropathologica Communications 2021 Nov; 9(1):177.
Application：IEM, IF, IHC-Fr, Mouse, Mouse brain, Mouse dentate gyrus.
- Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice.
Shaogui Wang, Xiaojuan Chao, Xiaoxiao Jiang, Tiantian Wang, Yssa Rodriguez, Ling Yang, Pal Pacher, Hong-Min Ni, Wen-Xing Ding.
Autophagy 2021 Oct; 28:1.
Application：WB-Ti, WB-Tr, Mouse, Mouse pancreatic tissue.
- Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Xiaojuan Chao, Shaogui Wang, Madeline Hlobik, Andrea Ballabio, Hong-Min Ni, Wen-Xing Ding.
The American Journal of Pathology 2022 Jan; 192(1):87.
Application：WB-Ti, WB-Tr, Mouse, Mouse liver, Mouse liver tumor.
- Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cells homeostasis.
Liliana S Alves, André R A Marques, Nuno Padrão, Filomena A Carvalho, José Ramalho, Catarina Lopes, Maria I L Soares, Clare E Futter, Teresa M V D Pinho E Melo, Nuno C Santos, Otília V Vieira.
Journal of Cell Science 2022 Mar; 135(5):jcs254631.
Application：WB, Human, Human Vascular Smooth Muscle cells.
- Global Rhes knockout in the Q175 Huntington's disease mouse model.
Taneli Heikkinen, Timo Bragge, Juha Kuosmanen, Teija Parkkari, Sanna Gustafsson, Mei Kwan, Jose Beltran, Afshin Ghavami, Srinivasa Subramaniam, Neelam Shahani, Uri Nimrod Ramírez-Jarquín, Larry Park, Ignacio Muñoz-Sanjuán, Deanna M Marchionini.
PLoS One 2021 Oct; 16(10):e0258486.
Application：TR-FRET, Mouse, Mouse striatum.
- Autophagy, TERT, and mitochondrial dysfunction in hyperoxia.
Andreas M Beyer, Laura E Norwood Toro, William E Hughes, Micaela Young, Anne V Clough, Feng Gao, Meetha Medhora, Said H Audi, Elizabeth R Jacobs.
American Journal of Physiology. Heart and Circulatory Physiology 2021 Nov; 321(5):H985.
Application：WB, Rat, Lung.
- Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
Yin Shi, Shengfeng Xu, Natalie Y L Ngoi, Yuanjian Hui, Zu Ye.
2021 Oct; 576:108.
Application：WB-Tr, Human, HCT-116, MCF-7 cells.
- Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.
Yamina Hamel, François-Xavier Mauvais, Marine Madrange, Perrine Renard, Corinne Lebreton, Ivan Nemazanyy, Olivier Pellé, Nicolas Goudin, Xiaoyun Tang, Mathieu P Rodero, Caroline Tuchmann-Durand, Patrick Nusbaum, David N Brindley, Peter van Endert, Pascale de Lonlay.
Cell Reports. Medicine 2021 Aug; 2(8):100370.
Application：IF, WB-Ce, Human, Human myoblasts.
- GSK-3 mediates nuclear translocation of p62/SQSTM1 in MPTP-induced mouse model of Parkinson's disease.
Yueyue Liu, Qiaoying Huang, Zijian Wei, Shanshan Ma, James R Woodgett, Mingtao Li, Junyu Li.
Neuroscience Letters 2021 Aug; 763:136177.
Application：WB-Ti, Mouse, Mouse ventral midbrain.
- ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Kathryn R Bowles, M Catarina Silva, Kristen Whitney, Taylor Bertucci, Joshua E Berlind, Jesse D Lai, Jacob C Garza, Nathan C Boles, Sidhartha Mahali, Kevin H Strang, Jacob A Marsh, Cynthia Chen, Derian A Pugh, Yiyuan Liu, Ronald E Gordon, Susan K Goderie, Rebecca Chowdhury, Steven Lotz, Keith Lane, John F Crary, Stephen J Haggarty, Celeste M Karch, Justin K Ichida, Alison M Goate, Sally Temple.
Cell 2021 Aug; 184(17):4547.
Application：WB-Tr, Human, Human cerebral organoids.
- Pathophysiological Effects of Overactive STIM1 on Murine Muscle Function and Structure.
Roberto Silva-Rojas, Anne-Laure Charles, Sarah Djeddi, Bernard Geny, Jocelyn Laporte, Johann Böhm.
Cells 2021 Jul; 10(7):1730.
Application：WB-Ti, Mouse, Mouse tibialis anterior and soleus muscles.
- Loss of FYCO1 leads to cataract formation.
Kiyotoshi Satoh, Yukitoshi Takemura, Motohiko Satoh, Kiyokazu Ozaki, Shunichiro Kubota.
Scientific Reports 2021 Jul; 11(1):13771.
Application：IF, IHC-P, WB-Tr, Mouse, Mouse eye.
- NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice.
Annadurai Anandhan, Nhat Nguyen, Arjun Syal, Luke A Dreher, Matthew Dodson, Donna D Zhang, Lalitha Madhavan.
Aging and Disease 2021 Jul; 12(4):964.
Application：WB-Ti, WB-Tr, Mouse, Mouse brain.
- Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy.
Yancheng Tang, Liming Wang, Tao Yi, Jun Xu, Jigang Wang, Jiang-Jiang Qin, Qilei Chen, Ka-Man Yip, Yihang Pan, Peng Hong, Yingying Lu, Han-Ming Shen, Hu-Biao Chen.
Acta Pharmaceutica Sinica. B 2021 Dec; 11(12):3966.
Application：IF, Human, HeLa cells.
- The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.
Sokhna M S Yakhine-Diop, Mario Rodríguez-Arribas, Saray Canales-Cortés, Guadalupe Martínez-Chacón, Elisabet Uribe-Carretero, Mercedes Blanco-Benítez, Gema Duque-González, Marta Paredes-Barquero, Eva Alegre-Cortés, Vicente Climent, Ana Aiastui, Adolfo López de Munain, José M Bravo-San Pedro, Mireia Niso-Santano, José M Fuentes, Rosa A González-Polo.
Cell Biology and Toxicology 2022 Oct; 38(5):889.
Application：IF, Human, R1441G human fibroblasts.
- Anti-tumor effects of an ID antagonist with no observed acquired resistance.
Paulina M Wojnarowicz, Marta Garcia Escolano, Yun-Han Huang, Bina Desai, Yvette Chin, Riddhi Shah, Sijia Xu, Saurabh Yadav, Sergey Yaklichkin, Ouathek Ouerfelli, Rajesh Kumar Soni, John Philip, David C Montrose, John H Healey, Vinagolu K Rajasekhar, William A Garland, Jeremy Ratiu, Yuan Zhuang, Larry Norton, Neal Rosen, Ronald C Hendrickson, Xi Kathy Zhou, Antonio Iavarone, Joan Massague, Andrew J Dannenberg, Anna Lasorella, Robert Benezra.
NPJ Breast Cancer 2021 May; 7(1):58.
Application：WB-Ce, Mouse, 4T1 cells.
- 7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts: 7-KC in osteoclasts.
Ok-Joo Sul, Guoen Li, Ji-Eun Kim, Eun-Sook Kim, Hye-Seon Choi.
The Journal of Nutritional Biochemistry 2021 May; 96:108783.
Application：WB-Ce, Mouse, Mouse bone marrow-derived macrophages.
- Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage.
Olga Ilnytska, Kimberly Lai, Kirill Gorshkov, Mark L Schultz, Bruce Nguyen Tran, Maciej Jeziorek, Thaddeus J Kunkel, Ruth D Azaria, Hayley S McLoughlin, Miriam Waghalter, Yang Xu, Michael Schlame, Nihal Altan-Bonnet, Wei Zheng, Andrew P Lieberman, Radek Dobrowolski, Judith Storch.
The Journal of Biological Chemistry 2021 May; 297(1):100813.
Application：IF, IHC-Fr, Human, Mouse, HeLa cells, Human fibroblasts, Mouse brain.
- Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency.
Joanna M Poczobutt, Andrew M Mikosz, Christophe Poirier, Erica L Beatman, Karina A Serban, Fabienne Gally, Danting Cao, Alexandra L McCubbrey, Christina F Cornell, Kelly S Schweitzer, Evgeny V Berdyshev, Irina A Bronova, François Paris and Irina Petrache.
American Journal of Respiratory Cell and Molecular Biology 2021 May; 64(5):629.
Application：WB-Ti, Mouse, Mouse lung.
- p62/Sequestosome 1 regulates transforming growth factor beta signaling and epithelial to mesenchymal transition in A549 cells.
Charles B Trelford, Evelyn Ng, Craig I Campbell, Gianni M Di Guglielmo.
Cellular Signalling 2021 May; 85:110040.
Application：IF, WB-Ce, WB-Tr, Human, A-549, Mv1Lu cells.
- Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy.
Khushboo Goel, Erica L Beatman, Nicholas Egersdorf, April Scruggs, Danting Cao, Evgeny V Berdyshev, Kelly S Schweitzer, Irina Petrache.
Cells 2021 May; 10(5):1200.
Application：WB-Ce, WB-Tr, Human, Human lung microvascular endothelial cells.
- CREG1 promotes lysosomal biogenesis and function.
Jie Liu, Yanmei Qi, Joshua Chao, Pranav Sathuvalli, Leonard Y Lee, Shaohua Li.
Autophagy 2021 May; 1.
Application：IF, WB-Ti, WB-Tr, Mouse, AML12, LO2 cells, Mouse liver.
- ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.
Dongfang Li, Peter Vogel, Xiujie Li-Harms, Bo Wang, Mondira Kundu.
Autophagy 2021 Apr; 1.
Application：IF, IHC-Fr, Mouse, Mouse skeletal muscle.
- ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration.
Isaac Tamargo-Gómez, Gemma G Martínez-García, María F Suárez, Verónica Rey, Antonio Fueyo, Helena Codina-Martínez, Gabriel Bretones, Xurde M Caravia, Etienne Morel, Nicolas Dupont, Roberto Cabo, Cristina Tomás-Zapico, Sylvie Souquere, Gerard Pierron, Patrice Codogno, Carlos López-Otín, Álvaro F Fernández, Guillermo Mariño.
Cell Death and Differentiation 2021 Sep; 28(9):2651.
Application：IF, WB-Ti, WB-Tr, Mouse, MEFs, Mouse heart, Mouse liver, Mouse skeletal muscle.
- High Dietary Phosphate Exacerbates and Acts Independently of Low Autophagy Activity in Pathological Cardiac Remodeling and Dysfunction.
Mingjun Shi, Sierra Shepard, Zhiyong Zhou, Jenny Maique, Olivia Seli, Orson W Moe, Ming Chang Hu.
Cells 2021 Apr; 10(4):777.
Application：WB-Ti, Mouse, Mouse heart.
- Inhibiting mTOR activity using AZD2014 increases autophagy in the mouse cerebral cortex.
Julien Bensalem, Célia Fourrier, Leanne K Hein, Sofia Hassiotis, Christopher G Proud, Timothy J Sargeant.
Neuropharmacology 2021 Mar; 190:108541.
Application：WB-Ti, Mouse, Mouse cerebral cortex, Mouse liver.
- Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 Interaction.
Sue Young Oh, Namju Kang, Jung Yun Kang, Ki Woo Kim, Jong-Hoon Choi, Yu-Mi Yang and Dong Min Shin.
Frontiers in Cell and Developmental Biology 2021 Mar; 9:646803.
Application：Co-IP, Mice, bone marrow-derived monocytes/macrophages (BMMs).
- Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice.
Hua Sun, Hong-Min Ni, Jennifer M McCracken, Jephte Y Akakpo, Sam Fulte, Tara McKeen, Hartmut Jaeschke, Hua Wang, Wen-Xing Ding.
Liver Research 2021 Jun; 5(2):79.
Application：WB-Ti, WB-Tr, Mouse, Mouse liver.
- The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease.
Briana R De Miranda, Sandra L Castro, Emily M Rocha, Christopher R Bodle, Katrina E Johnson, J Timothy Greenamyre.
Neurobiology of Disease 2021 Feb; 153:105312.
Application：IF, IHC-Fr, Rat, Rat brain.
- Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell.
Yizhu Mu, Yunash Maharjan, Raghbendra Kumar Dutta, Xiaofan Wei, Jin Hwi Kim, Jinbae Son, Channy Park, Raekil Park.
PLoS One 2021 Feb; 16(2):e0245799.
Application：WB-Ce, Mouse, Raw 264.7 cells.
- Identification of Novel Lipid Droplet Factors that Regulate Lipophagy and Cholesterol Efflux in Macrophage Foam Cells.
Sabrina Robichaud, Garrett Fairman, Viyashini Vijithakumar, Esther Mak, David P Cook, Alexander R Pelletier, Sylvain Huard, Barbara C Vanderhyden, Daniel Figeys, Mathieu Lavallée-Adam, Kristin Baetz, Mireille Ouimet.
Autophagy 2021 Feb; 1.
Application：IF, Human, THP-1 cells.
- DNAJB12 and Hsp70 Triage Arrested Intermediates of N1303K-CFTR for ER Associated-Autophagy.
Lihua He, Andrew S Kennedy, Scott Houck, Andrei Aleksandrov, Nancy L Quinney, Alexandra Cyr-Scully, Deborah M Cholon, Martina Gentzsch, Scott H Randell, Hong Yu Ren, Douglas M Cyr.
Molecular Biology of the Cell 2021 Apr; 32(7):538.
Application：WB-Tr, Human, Monkey, COS-7, HEK 293, HeLa cells.
- Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner.
Naho Nomura, Chiaki Ito, Takako Ooshio, Yuko Tadokoro, Susumu Kohno, Masaya Ueno, Masahiko Kobayashi, Atsuko Kasahara, Yusuke Takase, Kenta Kurayoshi, Sha Si, Chiaki Takahashi, Masaaki Komatsu, Toru Yanagawa, Atsushi Hirao.
Scientific Reports 2021 Jan; 11(1):1666.
Application：WB-Ce, Mouse, Mouse haematopoietic stem cells.
- Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation.
Jisu Park, Hyunwoo Choi, Young Doo Kim, Seo-Hyun Kim, Youbin Kim, Youngdae Gwon, Dong Young Lee, Sung-Hye Park, Won Do Heo, Yong-Keun Jung.
Molecular Psychiatry 2021 Oct; 26(10):5542.
Application：WB-Tr, Human, SH-SY5Y cells.
- Case Report of a pathologically confirmed vascular parkinsonism with early cognitive impairment and Behavioral disturbance.
Shouzi Zhang, Yuanyuan Wang, Lixin Liu, Li Zhang, Li Ma, Haiyan Wu, Xuelin He, Mingwei Zhu, Luning Wang, Fan Mei.
BMC Neurology 2021 Jan; 21(1):15.
Application：IHC-P, Human, Human hippocampus.
- Sorting nexin 5 mediates virus-induced autophagy and immunity.
Xiaonan Dong, Yuting Yang, Zhongju Zou, Yuting Zhao, Bo Ci, Lin Zhong, Madhura Bhave, Liwei Wang, Yi-Chun Kuo, Xiao Zang, Rui Zhong, Elizabeth R Aguilera, R Blake Richardson, Boris Simonetti, John W Schoggins, Julie K Pfeiffer, Li Yu, Xuewu Zhang, Yang Xie, Sandra L Schmid, Guanghua Xiao, Paul A Gleeson, Nicholas T Ktistakis, Peter J Cullen, Ramnik J Xavier, Beth Levine.
Nature 2021 Jan; 589(7842):456.
Application：WB-Tr, Human, HeLa cells.
- Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells.
Hyun-Young Lee, Seon-Hee Oh.
Biochemical and Biophysical Research Communications 2021 Jan; 534:128.
Application：WB-Ce, WB-Tr, Human, HK-2 cells.
- Measurement of autophagic flux in humans: an optimized method for blood samples.
Julien Bensalem, Kathryn J Hattersley, Leanne K Hein, Xiao Tong Teong, Julian M Carosi, Sofia Hassiotis, Randall H Grose, Célia Fourrier, Leonie K Heilbronn, Timothy J Sargeant.
Autophagy 2020 Dec; 1.
Application：WB-Ce, Human, Human PBMCs, Human PMNs.
- STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain.
Tara D Fischer, Chunxin Wang, Benjamin S Padman, Michael Lazarou, Richard J Youle.
The Journal of Cell Biology 2020 Dec; 219(12):e202009128.
Application：WB-Ce, WB-Tr, Human, HeLa cells,Human dermal fibroblasts.
- GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex.
Yuting Zhao, Zhongju Zou, Daxiao Sun, Yue Li, Sangita C Sinha, Li Yu, Lynda Bennett, Beth Levine.
Autophagy 2020 Nov; 1.
Application：WB-Ti, Mouse , Mouse heart, Mouse liver, Mouse skeletal muscle.
- Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
Shireen A Sarraf, Hetal V Shah, Gil Kanfer, Alicia M Pickrell, Lynne A Holtzclaw, Michael E Ward, Richard J Youle.
Molecular Cell 2020 Dec; 80(5):779.
Application：WB-Ce, WB-Tr, Mouse, Rat, Mouse brain, Rat cortical neurons.
- Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation.
Young Jin, Yul Ji, Yaechan Song, Sung Sik Choe, Yong Geun Jeon, Heeju Na, Tae Wook Nam, Hye Jeong Kim, Hahn Nahmgoong, Sung Min Kim, Jae-Woo Kim, Ki Taek Nam, Je Kyung Seong, Daehee Hwang, Chan Bae Park, In Hye Lee, Jae Bum Kim, Han-Woong Lee.
Diabetes 2021 Jan; 70(1):182.
Application：WB-Ce, WB-Ti, Mouse, Mouse adipocytes, Mouse liver, Mouse muscle.
- GADD34 is a modulator of autophagy during starvation.
Gennaro Gambardella, Leopoldo Staiano, Maria Nicoletta Moretti, Rossella De Cegli, Luca Fagnocchi, Giuseppe Di Tullio, Sara Polletti, Clarissa Braccia, Andrea Armirotti, Alessio Zippo, Andrea Ballabio, Maria Antonietta De Matteis, Diego di Bernardo.
Science Advances 2020 Sep; 6(39):eabb0205.
Application：WB-Tr, Hamster, CHO cells.
- The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.
Chiara Fucci, Massimo Resnati, Elena Riva, Tommaso Perini, Elena Ruggieri, Ugo Orfanelli, Francesca Paradiso, Floriana Cremasco, Andrea Raimondi, Elena Pasqualetto, Mario Nuvolone, Luca Rampoldi, Simone Cenci, Enrico Milan.
Cell Reports 2020 Sep; 32(12):108162.
Application：IP, WB-Tr, Human, MM.1S, OPM2, RPMI 8226 cells.
- Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.
Angel K Kongsomboonvech, Felipe Rodriguez, Anh L Diep, Brandon M Justice, Brayan E Castallanos, Ana Camejo, Debanjan Mukhopadhyay, Gregory A Taylor, Masahiro Yamamoto, Jeroen P J Saeij, Michael L Reese, Kirk D C Jensen.
PLoS Pathogens 2020 Aug; 16(8):e1008327.
Application：IF, Mouse, Mouse bone marrow-derived macrophages.
- Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice.
Man Wu, Guang Lu, Yuan-Zhi Lao, Hong Zhang, Dan Zheng, Zhao-Qing Zheng, Juan Yi, Qian Xiang, Li-Ming Wang, Hong-Sheng Tan, Hua Zhou, Han-Ming Shen, Hong-Xi Xu.
Acta Pharmacologica Sinica 2021 Feb; 42(2):199.
Application：IF, WB-Ce, Human, HeLa, SH-SY5Y cells.
- Torin2 inhibits the EGFR-TKI resistant Non-Small Lung Cancer cell proliferation through negative feedback regulation of Akt/mTOR signaling.
Yi Hu, Ji Zhang, Qun Liu, Mingyao Ke, Jiurong Li, Wenhao Suo, Weixi Guo, Aiping Ma.
Journal of Cancer 2020 Jul; 11(19):5746.
Application：WB-Ce, WB-Tr, Human, PC-9 cells.
- MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
Laura Cinque, Chiara De Leonibus, Maria Iavazzo, Natalie Krahmer, Daniela Intartaglia, Francesco Giuseppe Salierno, Rossella De Cegli, Chiara Di Malta, Maria Svelto, Carmela Lanzara, Marianna Maddaluno, Luca Giorgio Wanderlingh, Antje K Huebner, Marcella Cesana, Florian Bonn, Elena Polishchuk, Christian A Hübner, Ivan Conte, Ivan Dikic, Matthias Mann, Andrea Ballabio, Francesca Sacco, Paolo Grumati, Carmine Settembre.
The EMBO Journal 2020 Sep; 39(17):e105696.
Application：WB-Tr, Rat, Rat chondrocytes.
- Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics.
María Paz Hernández-Cáceres, Karina Cereceda, Sergio Hernández, Ying Li, Carla Narro, Patricia Rivera, Patricio Silva, Yenniffer Ávalos, Claudia Jara, Paulina Burgos, Lilian Toledo-Valenzuela, Pablo Lagos, Flavia Cifuentes Araneda, Claudio Perez-Leighton, Cristina Bertocchi, Deborah J Clegg, Alfredo Criollo, Cheril Tapia-Rojas, Patricia V Burgos, Eugenia Morselli.
Molecular & Cellular Oncology 2020 Jul; 7(5):1789418.
Application：IF, WB-Ce, Mouse, N43/5 cells.
- Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity.
Keum-Young So, Byung-Hyun Park, Seon-Hee Oh.
Cell Biology and Toxicology 2021 Apr; 37(2):193.
Application：IF, WB-Ce, WB-Tr, Mouse, MES13 cells.
- ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia.
Doh Yu Hwang, Ju-In Eom, Ji Eun Jang, Hoi-Kyung Jeung, Haerim Chung, Jin Seok Kim, June-Won Cheong, Yoo Hong Min.
Journal of Experimental & Clinical Cancer Research 2020 May; 39(1):85.
Application：WB, Human, MV4-11, U937 cells.
- Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies.
Janin Lautenschläger, Sara Wagner-Valladolid, Amberley D Stephens, Ana Fernández-Villegas, Colin Hockings, Ajay Mishra, James D Manton, Marcus J Fantham, Meng Lu, Eric J Rees, Clemens F Kaminski, Gabriele S Kaminski Schierle.
The Journal of Biological Chemistry 2020 Jul; 295(30):10138.
Application：IF, Human, SH-SY5Y cells .
- Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury.
Jihoon Nah, Peiyong Zhai, Chun-Yang Huang, Álvaro F Fernández, Satvik Mareedu, Beth Levine, Junichi Sadoshima.
The Journal of Clinical Investigation 2020 Jun; 130(6):2978.
Application：WB, Mouse, Rat, Heart, Neonatal rat CMs.
- Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory.
Ouyang X, Ahmad I, Johnson MS, Redmann M, Craver J, Wani WY, Benavides GA, Chacko B, Li P, Young M, Jegga AG, Darley-Usmar V, Zhang J.
Laboratory Investigation; a Journal of Technical Methods and Pathology 2020 Sep; 100(9):1238.
Application：IHC-P, WB-Ti, Mouse, Mouse brains.
- Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Nimesha Tadepalle, Lennart Robers, Matteo Veronese, Peter Zentis, Felix Babatz, Susanne Brodesser, Anja V Gruszczyk, Astrid Schauss, Stefan Höning, Elena I Rugarli.
Life Science Alliance 2020 Apr; 3(6):e202000715.
Application：WB-Ce, WB-Tr, Mouse, NSC34 cells.
- Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.
Chung PED, Gendoo DMA, Ghanbari-Azarnier R, Liu JC, Jiang Z, Tsui J, Wang DY, Xiao X, Li B, Dubuc A, Shih D, Remke M, Ho B, Garzia L, Ben-David Y, Kang SG, Croul S, Haibe-Kains B, Huang A, Taylor MD, Zacksenhaus E.
Nature Communications 2020 Apr; 11(1):1825.
Application：IF, WB-Ce, Mouse, PB cells.
- A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons.
Stathakos P, Jiménez-Moreno N, Crompton LA, Nistor PA, Badger JL, Barbuti PA, Kerrigan TL, Randall AD, Caldwell MA, Lane JD.
Autophagy 2020 Apr; 1.
Application：WB-Ce, Human, Human dopaminergic neurons.
- Radiation Induces Autophagy via Histone H4 Lysine 20 Trimethylation in Non-small Cell Lung Cancer Cells.
Tae-Gul Lee, Seo Yun Kim, Hye-Ryoun Kim, Hyunggee Kim, Cheol Hyeon Kim.
Anticancer Research 2020 May; 40(5):2537.
Application：WB, Human, A549, H460 cells.
- CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy.
Pla-Martín D, Schatton D, Wiederstein JL, Marx MC, Khiati S, Krüger M, Rugarli EI.
The EMBO Journal 2020 Mar; e102731.
Application：WB-Ti, Mouse, Mouse liver.
- The HOPS Complex Subunit VPS39 controls ciliogenesis through autophagy.
Iaconis D, Crina C, Brillante S, Indrieri A, Morleo M, Franco B.
Human Molecular Genetics 2020 Apr; 29(6):1018.
Application：WB-Tr, Human, HK2 cells.
- Dimethyloxaloylglycine induces pexophagy in a HIF-2α dependent manner involving autophagy receptor p62.
Mu Y, Maharjan Y, Dutta RK, Kim H, Wei X, Kim JH, Kim D, Park C, Park R.
Biochemical and Biophysical Research Communications 2020 Feb; [Epub].
Application：IF, WB-Ce, WB-Tr, Human, Huh7 cells.
- Association of autophagy status with amount of Fusobacterium nucleatum in colorectal cancer.
Haruki K, Kosumi K, Hamada T, Twombly TS, Väyrynen JP, Kim SA, Masugi Y, Qian ZR, Mima K, Baba Y, da Silva A, Borowsky J, Arima K, Fujiyoshi K, Lau MC, Li P, Guo C, Chen Y, Song M, Nowak JA, Nishihara R, Yanaga K, Zhang X, Wu K, Bullman S, Garrett WS, Huttenhower C, Meyerhardt JA, Giannakis M, Chan AT, Fuchs CS, Ogino S.
The Journal of Pathology 2020 Apr; 250(4):397.
Application：IHC-P, Human, Human colorectal cancer.
- Hepatitis Delta Virus Alters the Autophagy Process To Promote Its Genome Replication.
Khabir M, Aliche AZ, Sureau C, Blanchet M, Labonté P.
Journal of Virology 2020 Jan; 94(4):e01936.
Application：WB-Tr, Human, Huh7 cells.
- Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms.
Siwen Yang, Yunhe Qu, Hang Zhang, Zhujun Xue, Ting Liu, Lulu Yang, Lin Sun, Yifa Zhou, Yuying Fan.
Food & Function 2020 Jan; 11(1):424.
Application：WB-Ce, Human, Hepa1-6 cells.
- Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans.
Wang S, Ni HM, Chao X, Ma X, Kolodecik T, De Lisle R, Ballabio A, Pacher P, Ding WX.
Cellular and Molecular Gastroenterology and Hepatology 2020 Jan; 10(1):59.
Application：WB-Ti, Mouse, Mouse pancreatic tissues.
- Regulation of endo-lysosomal pathway and autophagic flux by broad-spectrum antipathogen inhibitor ABMA.
Wu Y, Boulogne C, Carle S, Podinovskaia M, Barth H, Spang A, Cintrat JC, Gillet D, Barbier J.
The FEBS Journal 2020 Aug; 287(15):3184.
Application：IF, WB-Ce, Human, Mouse, A-549, RAW264.7 cells.
- Lysosomal Dysregulation in the Murine App NL-G-F/NL-G-F Model of Alzheimer's Disease.
Lauren S Whyte, Sofia Hassiotis, Kathryn J Hattersley, Kim M Hemsley, John J Hopwood, Adeline A Lau, Timothy J Sargeant.
Neuroscience 2020 Mar; 429:143.
Application：WB-Ti, Mouse, Mouse cortical homogenates.
- The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance.
Shi M, Maique J, Shaffer J, Davidson T, Sebti S, Fernández ÁF, Zou Z, Yan S, Levine B, Moe OW, Hu MC.
FASEB Journal 2020 Feb; 34(2):3129.
Application：WB-Ce, WB-Ti, Mouse, Mouse kidney, OKP cells.
- Limited spread of pathology within the brainstem of α-synuclein BAC transgenic mice inoculated with preformed fibrils into the gastrointestinal tract.
Uemura N, Yagi H, Uemura MT, Yamakado H, Takahashi R.
Neuroscience Letters 2020 Jan; 716:134651.
Application：IF, IHC-P, Mouse, Mouse brains.
- Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.
Fares Bassil, Hannah J Brown, Shankar Pattabhiraman, Joe E Iwasyk, Chantal M Maghames, Emily S Meymand, Timothy O Cox, Dawn M Riddle, Bin Zhang, John Q Trojanowski, Virginia M-Y Lee.
Neuron 2020 Jan; 105(2):260.
Application：IF, IHC, WB-Ti, Mouse, Mouse brain.
- Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells.
Harder BG, Peng S, Sereduk CP, Sodoma AM, Kitange GJ, Loftus JC, Sarkaria JN, Tran NL.
Molecular Immunology 2019 Nov; 25(1):49.
Application：WB-Ce, Human, T98G cells.
- Autophagy is required for performance adaptive response to resistance training and exercise-induced adult neurogenesis.
Codina-Martínez H, Fernández-García B, Díez-Planelles C, Fernández ÁF, Higarza SG, Fernández-Sanjurjo M, Díez-Robles S, Iglesias-Gutiérrez E, Tomás-Zapico C.
Scandinavian Journal of Medicine & Science in Sports 2020 Feb; 30(2):238.
Application：WB-Ti, Mouse, Mouse brains.
- Fat cadherins in mouse models of degenerative ataxias.
Baron O, Grieshober D, Dias C, Fanto M.
Scientific Reports 2019 Nov; 9(1):16155.
Application：WB-Ti, Mouse, Brainstem, Cerebellum.
- LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease.
Rocha EM, De Miranda BR, Castro S, Drolet R, Hatcher NG, Yao L, Smith SM, Keeney MT, Di Maio R, Kofler J, Hastings TG, Greenamyre JT.
Neurobiology of Disease 2019 Oct; 134:104626.
Application：IF, IHC, Rat, Rat brains.
- Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss.
Park HJ, Gholam-Zadeh M, Suh JH, Choi HS.
Oxidative Medicine and Cellular Longevity 2019 Oct; 2019:8982147.
Application：WB-Ce, Mouse, Bone marrow-derived macrophages.
- Effect of early-stage autophagy inhibition in BRAFV600E autophagy-dependent brain tumor cells.
Zahedi S, Fitzwalter BE, Morin A, Grob S, Desmarais M, Nellan A, Green AL, Vibhakar R, Hankinson TC, Foreman NK, Mulcahy Levy JM.
Cell Death & Disease 2019 Sep; 10(9):679.
Application：WB-Ce, Human, MAF794, AM38 cells.
- Poly-ubiquitinated p62/SQSTM1-mediated hemeoxygenase-1 stabilization plays a critical role in cadmium-induced apoptosis of mouse monocyte Raw264.7 cells.
Jung KT, Oh SH.
Biochemical and Biophysical Research Communications 2019 Nov; 519(2):409.
Application：IF, WB-Ce, WB-Tr, Human, Rat, HepG2, H460, NRK52E cells.
- The Mitochondrial Antioxidant SS-31 Modulates Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Type 2 Diabetes.
Escribano-López I, de Marañon AM, Iannantuoni F, López-Domènech S, Abad-Jiménez Z, Díaz P, Solá E, Apostolova N, Rocha M, Víctor VM.
Journal of Clinical Medicine 2019 Aug; 8(9):E1322.
Application：WB-Ce, Human, Leukocytes.
- Polyubiquitination of p62/SQSTM1 is a prerequisite for Fas/CD95 aggregation to promote caspase-dependent apoptosis in cadmium-exposed mouse monocyte RAW264.7 cells.
Jung KT, Oh SH.
Scientific Reports 2019 Aug; 9(1):12240.
Application：WB-Ce, Mouse, Raw 264.7 cells.
- Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G.
Cell Metabolism 2019 Oct; 30(4):754.
Application：WB-Ce, Mouse, Mouse hepatocytes.
- Sarcolipin overexpression impairs myogenic differentiation in Duchenne muscular dystrophy.
Niranjan N, Mareedu S, Tian Y, Kodippili K, Fefelova N, Voit A, Xie LH, Duan D, Babu GJ.
American Journal of Physiology. Cell Physiology 2019 Oct; 317(4):C813.
Application：WB, Mouse, C2C12 cells.
- Autophagy flux in critical illness, a translational approach.
Tardif N, Polia F, Tjäder I, Gustafsson T, Rooyackers O.
Scientific Reports 2019 Jul; 9(1):10762.
Application：Func, IF, Human, Primary myotubes, Serum.
- Role of Glucosylceramide in Lung Endothelial Cell Fate and Emphysema.
Koike K, Berdyshev EV, Mikosz AM, Bronova IA, Bronoff AS, Jung JP, Beatman EL, Ni K, Cao D, Scruggs AK, Serban KA, Petrache I.
American Journal of Respiratory and Critical Care Medicine 2019 Jul; [Epub].
Application：WB-Tr, Human, Human lung microvascular endothelial cells.
- Diverse Consequences in Liver Injury in Mice with Different Autophagy Functional Status Treated with Alcohol.
Yan S, Zhou J, Chen X, Dong Z, Yin XM.
The American Journal of Pathology 2019 Sep; 189(9):1744.
Application：WB-Ti, Mouse, Mouse livers.
- A Novel Role for Helicobacter pylori Gamma-Glutamyltranspeptidase in Regulating Autophagy and Bacterial Internalization in Human Gastric Cells.
Bravo J, Díaz P, Corvalán AH, Quest AFG.
Cancers 2019 Jun; 11(6):E801.
Application：WB, Human, AGS, GES-1 cells.
- miR-181a/b downregulation exerts a protective action on mitochondrial disease models.
Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez-Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao-Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B.
EMBO Molecular Medicine 2019 May; 11(5):e8734.
Application：WB-Ti, Mouse, Mouse eyes.
- Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack.
Martinez-Arroyo O, Gruevska A, Victor VM, Gonzalez-Polo RA, Yakhine-Diop S, Fuentes JM, Esplugues JV, Blas-Garcia A, Apostolova N.
Antiviral Research 2019 May; 168:36.
Application：WB, Rat, Rat astrocytes.
- Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Wirth M, Zhang W, Razi M, Nyoni L, Joshi D, O'Reilly N, Johansen T, Tooze SA, Mouilleron S.
Nature Communications 2019 May; 10(1):2055.
Application：WB-Tr, Human, HEK 293, HEK 293A, HeLa cells.
- Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Park JS, Lee YS, Lee DH, Bae SH.
Free Radical Biology & Medicine 2019 Apr; 137:143.
Application：WB, Mouse, MEFs, Hepa1c1c7 cells.
- Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
Sica V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S, Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N, Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC, Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.
Cell Reports 2019 Apr; 27(3):820.
Application：WB-Ce, Human, NCI-H460 cells.
- Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1-deficiency increases amino acid use and impairs muscle function.
Zhao L, Pascual F, Bacudio L, Suchanek AL, Young PA, Li LO, Martin SA, Camporez JP, Perry RJ, Shulman GI, Klett EL, Coleman RA.
The Journal of Biological Chemistry 2019 May; 294(22):8819.
Application：WB-Ti, Mouse, Mouse muscles.
- ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
Wang B, Maxwell BA, Joo JH, Gwon Y, Messing J, Mishra A, Shaw TI, Ward AL, Quan H, Sakurada SM, Pruett-Miller SM, Bertorini T, Vogel P, Kim HJ, Peng J, Taylor JP, Kundu M.
Molecular Cell 2019 May; 74(4):742.
Application：IF, IHC-Fr, Mouse, Mouse quadriceps.
- Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5.
Hernández-Cáceres MP, Toledo-Valenzuela L, Díaz-Castro F, Ávalos Y, Burgos P, Narro C, Peña-Oyarzun D, Espinoza-Caicedo J, Cifuentes-Araneda F, Navarro-Aguad F, Riquelme C, Troncoso R, Criollo A, Morselli E.
Frontiers in Endocrinology 2019 Mar; 10:176.
Application：IF, WB, Mouse, N43/5 cells.
- Sex differences in rotenone sensitivity reflect the male-to-female ratio in human Parkinson's disease incidence.
De Miranda BR, Fazzari M, Rocha EM, Castro S, Greenamyre JT.
Toxicological Sciences 2019 Jul; 170(1):133.
Application：IF, IHC-Fr, Rat, Rat brains.
- Human cytomegalovirus hijacks the autophagic machinery and LC3 homologs in order to optimize cytoplasmic envelopment of mature infectious particles.
Taisne C, Lussignol M, Hernandez E, Moris A, Mouna L, Esclatine A.
Scientific Reports 2019 Mar; 9(1):4560.
Application：WB, Human, HFF cells.
- Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Vargas JNS, Wang C, Bunker E, Hao L, Maric D, Schiavo G, Randow F, Youle RJ.
Molecular Cell 2019 Apr; 74(2):347.
Application：WB, Human, HeLa cells.
- Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells.
Aydinlik S, Dere E, Ulukaya E.
Biochimica et Biophysica acta. General Subjects 2019 Feb; 1863(5):903.
Application：WB, Human, HeLa cells.
- Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice.
Wang H, Ni HM, Chao X, Ma X, Rodriguez YA, Chavan H, Wang S, Krishnamurthy P, Dobrowsky R, Xu DX, Jaeschke H, Ding WX.
Redox Biology 2019 Apr; 22:101148.
Application：WB-Ti, Mouse, Liver.
- The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.
Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F.
Nature Communications 2019 Feb; 10(1):651.
Application：WB, Human, U2OS, HCT116, HepG2 Cells.
- Chlorpromazine protects against acetaminophen-induced liver injury in mice by modulating autophagy and c-Jun N-terminal kinase activation.
Yuan Li, Hong-Min Ni, Hartmut Jaeschke, Wen-Xing Ding.
Liver Research 2019 Mar; 3(1):65.
Application：WB-Ti, Mouse, Mouse liver.
- Autophagy Pathway Mapping to Elucidate the Function of Novel Autophagy Regulators Identified by High-Throughput Screening.
Wirth M, Tooze SA.
Methods in Molecular Biology (Clifton, N.J.) 2019 Jan; 1880:375.
Application：IF, WB, Human, hiPSC neuronal cultures.
- Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson's Disease Research.
Stathakos P, Jimenez-Moreno N, Crompton L, Nistor P, Caldwell MA, Lane JD.
Methods in Molecular Biology (Clifton, N.J.) 2019 Jan; 1880:257.
Application：IF, WB, Human, hiPSC neuronal cultures.
- Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice.
Koike K, Beatman EL, Schweitzer K, Justice MJ, Mikosz AM, Ni K, Clauss MA, Petrache I.
American Journal of Physiology. Lung Cellular and Molecular Physiology 2019 Mar; 316(3):L558.
Application：WB-Ti, Mouse, Mouse lungs.
- A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex.
Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C.
The EMBO Journal 2019 Jan; 38(2):e99847.
Application：WB-Tr, Human, Saos2 cells.
- Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis.
Civiletto G, Dogan SA, Cerutti R, Fagiolari G, Moggio M, Lamperti C, Benincá C, Viscomi C, Zeviani M.
EMBO Molecular Medicine 2018 Nov; 10(11): e8799.
Application：WB-Tr, Mouse, Skeletal muscle.
- Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.
Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE, Boudina S.
Cell Reports 2018 Nov; 25(7):1708.
Application：WB-Ti, Mouse, Epididymal white adipose, Brown adipose tissue.
- Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Rashid T, Nemazanyy I, Paolini C, Tatsuta T, Crespin P, de Villeneuve D, Brodesser S, Benit P, Rustin P, Baraibar MA, Agbulut O, Olivier A, Protasi F, Langer T, Chrast R, de Lonlay P, de Foucauld H, Blaauw B, Pende M.
The EMBO Journal 2018 Nov; e99576.
Application：WB-Ti, Mouse, Rat, Skeletal muscles.
- Vincristine Ablation of Sirt2 Induces Cell Apoptosis and Mitophagy via Hsp70 Acetylation in MDA-MB-231 Cells.
Sun F, Jiang X, Wang X, Bao Y, Feng G, Liu H, Kou X, Zhu Q, Jiang L, Yang Y.
Biochemical Pharmacology 2018 Oct; [Epub].
Application：WB, Human, MDA-MB-231 cells.
- Beclin1 decreases the RIPA-insoluble fraction of amyotrophic lateral sclerosis-linked SOD1 mutant via autophagy.
Wei YM, Han B.
Neuroscience Letters 2018 Oct; 690:106.
Application：WB, Human, HEK 293T, NSC34 cells.
- Probing aggrephagy using chemically-induced protein aggregates.
Janssen AFJ, Katrukha EA, van Straaten W, Verlhac P, Reggiori F, Kapitein LC.
Nature Communications 2018 Oct; 9(1):4245.
Application：IF, WB, Human, HeLa cells.
- LC3B is not recruited along with the autophagy elongation complex (ATG5-12/16L1) at HCV replication site and is dispensable for viral replication.
Fahmy AM, Khabir M, Blanchet M, Labonté P.
PLoS One 2018 Oct; 13(10):e0205189.
Application：WB, Human, Huh7 cells.
- Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins.
Winer H, Fraiberg M, Abada A, Dadosh T, Tamim-Yecheskel BC, Elazar Z.
Nature Communications 2018 Sep; 9(1):3744.
Application：WB-Ce, WB-Tr, Human, HeLa cells.
- IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice.
Valladares D, Utreras-Mendoza Y, Campos C, Morales C, Diaz-Vegas A, Contreras-Ferrat A, Westermeier F, Jaimovich E, Marchi S, Pinton P, Lavandero S.
Biochimica et Biophysica Acta. Molecular Basis of Disease 2018 Nov; 1864(11):3685.
Application：WB-Ti, Mouse, Mouse skeletal muscle fibers.
- Significant predictors of overall survival in patients with hepatocellular carcinoma after surgical resection.
Lin CW, Chen YS, Lin CC, Lee PH, Lo GH, Hsu CC, Hsieh PM, Koh KW, Bair MJ, Dai CY, Huang JF, Chuang WL, Chen YL, Yu ML.
PLoS One 2018 Sep; 13(9):e0202650.
Application：IHC, Human, Hepatocellular carcinoma.
- AMH prevents primordial ovarian follicle loss and fertility alteration in cyclophosphamide-treated mice.
Sonigo C, Beau I, Grynberg M, Binart N.
FASEB Journal 2018 Aug; fj201801089R.
Application：WB-Ti, Mouse, Ovary.
- Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C.
Cell Metabolism 2018 Aug; [Epub].
Application：WB-Ti, Mouse, Skeletal muscle.
- An Engineered DC-Targeting Lentivector Induces Robust T Cell Responses and Inhibits HBV Replication in HBV Transgenic Mice via Upregulating T Cell Autophagy.
Ma S, Chen X, Tan Q, Dai S, Li D, Wu S, Yu Y, Zang G, Tang Z.
Cellular Physiology and Biochemistry 2018 Jul; 48(3):1041.
Application：IP, WB, Mouse, Mouse T cells.
- Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.
Manzella N, Santin Y, Maggiorani D, Martini H, Douin-Echinard V, Passos JF, Lezoualc'h F, Binda C, Parini A, Mialet-Perez J.
Aging Cell 2018 Jul; e12811.
Application：WB, Rat, H9C2 cells.
- LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
Henderson MX, Peng C, Trojanowski JQ, Lee VMY.
Acta Neuropathologica Communications 2018 May; 6(1):45.
Application：WB-Ce, Mouse, Primary hippocampal neurons.
- Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation.
Li Y, Chao X, Yang L, Lu Q, Li T, Ding WX, Ni HM.
The American Journal of Pathology 2018 Aug; 188(8):1833.
Application：WB, Mouse, Wild-type, Atg-5 KO hepatocytes.
- Blocking Autophagy in Oligodendrocytes Limits Functional Recovery after Spinal Cord Injury.
Ohri SS, Bankston AN, Mullins SA, Liu Y, Andres KR, Beare JE, Howard RM, Burke DA, Riegler AS, Smith AE, Hetman M, Whittemore SR.
The Journal of Neuroscience 2018 Jun; 38(26):5900.
Application：IHC, WB-Ti, Mouse, Spinal cord.
- Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice.
Chao X, Wang S, Zhao K, Li Y, Williams JA, Li T, Chavan H, Krishnamurthy P, He XC, Li L, Ballabio A, Ni HM, Ding WX.
Gastroenterology 2018 May; [Epub].
Application：WB-Ti, Mouse, Liver.
- Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.
Liu ZQ, Lee JN, Son M, Lim JY, Dutta RK, Maharjan Y, Kwak S, Oh GT, Byun K, Choe SK, Park R.
Autophagy 2018 May; 14(6):1011.
Application：WB, Human, Mouse, RPE1, HK2, A549, MEF cells.
- GIMAP6 is required for T cell maintenance and efficient autophagy in mice.
Pascall JC, Webb LMC, Eskelinen EL, Innocentin S, Attaf-Bouabdallah N, Butcher GW.
PLoS One 2018 May; 13(5):e0196504.
Application：WB-Ce, Mouse, Spleen.
- Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors.
Aveic S, Pantile M, Polo P, Sidarovich V, De Mariano M, Quattrone A, Longo L, Tonini GP.
Cancer Cell International 2018 Apr; 18:62.
Application：WB, Human, Kelly, SH-SY5Y cells.
- Protective role of Parkin in skeletal muscle contractile and mitochondrial function.
Gouspillou G, Godin R, Piquereau J, Picard M, Mofarrahi M, Mathew J, Purves-Smith FM, Sgarioto N, Hepple RT, Burelle Y, Hussain SN.
The Journal of Physiology 2018 Apr; [Epub].
Application：WB, Mouse, Skeletal muscle.
- Autophagy alteration prevents primary cilium disassembly in RPE1 cells.
Maharjan Y, Lee JN, Kwak S, Lim H, Dutta RK, Liu ZQ, So HS, Park R.
Biochemical and Biophysical Research Communications 2018 Jun; 500(2):242.
Application：WB-Ce, Human, RPE1 cells.
- Graphene oxide sensitizes cancer cells to chemotherapeutics by inducing early autophagy events, promoting nuclear trafficking and necrosis.
Lin KC, Lin MW, Hsu MN, Yu-Chen G, Chao YC, Tuan HY, Chiang CS, Hu YC.
Theranostics 2018 Mar; 8(9):2477.
Application：IF, Human, Mouse, A-549, CT26, Skov-3 cells.
- Neuroprotective effects of creatine in the CMVMJD135 mouse model of spinocerebellar ataxia type 3.
Duarte-Silva S, Neves-Carvalho A, Soares-Cunha C, Silva JM, Teixeira-Castro A, Vieira R, Silva-Fernandes A, Maciel P.
Movement Disorders 2018 May; 33(5):815.
Application：WB, Mouse, Brain.
- Quantifying autophagy using novel LC3B and p62 TR-FRET assays.
Bresciani A, Spiezia MC, Boggio R, Cariulo C, Nordheim A, Altobelli R, Kuhlbrodt K, Dominguez C, Munoz-Sanjuan I, Wityak J, Fodale V, Marchionini DM, Weiss A.
PLoS One 2018 Mar; 13(3):e0194423.
Application：TR-FRET, WB-Tr, Human, Rat, Astrocytes, HEK 293T cells, Rat neurons.
- Identification of an IL-1-induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR- PCa cells.
Thomas-Jardin SE, Kanchwala MS, Jacob J, Merchant S, Meade RK, Gahnim NM, Nawas AF, Xing C, Delk NA.
Prostate 2018 Jun; 78(8):595.
Application：WB, Human, DU145 PCa, LNCaP, MDA-PCa-2b, PC3 cell lines.
- Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction.
Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, Rojo de la Vega M, Cholanians AB, Wong PK, Chapman E, Zhang DD.
Molecular and Cellular Biology 2018 Mar; [Epub].
Application：Immunoblotting, Human, HeLa cells.
- High-Fructose Consumption Impairs the Redox System and Protein Quality Control in the Brain of Syrian Hamsters: Therapeutic Effects of Melatonin.
Bermejo-Millo JC, Guimaraes MRM, de Luxan-Delgado B, Potes Y, Perez-Martinez Z, Diaz-Luis A, Caballero B, Solano JJ, Vega-Naredo I, Coto-Montes A.
Molecular Neurobiology 2018 Feb; [Epub].
Application：WB-Ce, Hamsters, Brain tissue homogenates.
- Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice.
Yamada S, Takashina Y, Watanabe M, Nagamine R, Saito Y, Kamada N, Saito H.
Oncotarget 2018 Jan; 9(11):9925.
Application：WB-Ti, Mouse, Mouse livers.
- Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.
Ordóñez-Gutiérrez L, Benito-Cuesta I, Abad JL, Casas J, Fábrias G, Wandosell F.
Pharmaceutical Research 2018 Feb; 35(3):49.
Application：WB-Ce, Mouse, Primary cerebellar granule cells.
- Low-level arsenic causes proteotoxic stress and not oxidative stress.
Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD.
Toxicology and Applied Pharmacology 2018 Feb; 341:106.
Application：WB, Human, Mouse, HeLa, HEK 293, HEMn-LP, NIH 3T3 cells.
- Temporal partitioning of adaptive responses of the murine heart to fasting.
Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado BA, Peliciari-Garcia RA, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME.
Life Sciences 2018 Mar; 197:30.
Application：WB-Ti, Mouse , Mouse hearts.
- A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer.
Cevatemre B, Erkısa M, Aztopal N, Karakas D, Alper P, Tsimplouli C, Sereti E, Dimas K, Armutak EII, Gurevin EG, Uvez A, Mori M, Berardozzi S, Ingallina C, D'Acquarica I, Botta B, Ozpolat B, Ulukaya E.
Pharmacological Research 2018 Mar; 129:500.
Application：WB-Ce, Human, MCF-7 cells.
- Autophagic processes in Mytilus galloprovincialis hemocytes: Effects of Vibrio tapetis.
Balbi T, Cortese K, Ciacci C, Bellese G, Vezzulli L, Pruzzo C, Canesi L.
Fish & Shellfish Immunology 2017 Dec; 73:66.
Application：WB-Ce, Mussels, Mytilus hemocytes.
- Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration.
Baron O, Boudi A, Dias C, Schilling M, Nölle A, Vizcay-Barrena G, Rattray I, Jungbluth H, Scheper W, Fleck RA, Bates GP, Fanto M.
Current Biology : CB 2017 Nov; [Epub].
Application：IF, IHC, WB-Ce, Human, Mouse, Human fibroblasts, Mouse brain.
- Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level.
Rubio-González A, Bermejo-Millo JC, de Luxán-Delgado B, Potes Y, Pérez-Martínez Z, Boga JA, Vega-Naredo I, Caballero B, Solano JJ, Coto-Montes A; Members of Research Team cROS (cellular Response to Oxidative Stress).
Molecular Neurobiology 2017 Oct; [Epub].
Application：WB-Ti, Mouse, Mouse brain.
- PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles.
Merrill NM, Schipper JL, Karnes JB, Kauffman AL, Martin KR, MacKeigan JP.
PLoS One 2017 Sep; 12(9):e0184909.
Application：WB-Tr, Human, U-2 OS cells.
- mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.
Bartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano AC, Monfregola J, De Gennaro E, Nusco E, Azario I, Lanzara C, Serafini M, Levine B, Ballabio A, Settembre C.
The Journal of Clinical Investigation 2017 Sep; 127(10):3717.
Application：WB-Ce, Mouse, Mouse primary chondrocytes.
- Activation of transient receptor potential melastatin 7 (TRPM7) channel increases basal autophagy and reduces amyloid β-peptide.
Oh HG, Chung S.
Biochemical and Biophysical Research Communications 2017 Nov; 493(1):494.
Application：WB, Human, PS-1 cells.
- Determination of Autophagy in the Caco-2 Spontaneously Differentiating Model of Intestinal Epithelial Cells.
Tunçer S, Banerjee S.
Methods in Molecular Biology (Clifton, N.J.) 2017 Aug; [Epub].
Application：WB-Ce, Human, Caco-2 cells.
- A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C.
PLoS Genetics 2017 Aug; 13(8):e1006962.
Application：WB-Ti, Mouse, Mouse skeletal muscle.
- N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease.
García-Sanz P, Orgaz L, Bueno-Gil G, Espadas I, Rodríguez-Traver E, Kulisevsky J, Gutierrez A, Dávila J, González-Polo RA, Fuentes JM, Mir P, Vicario C, Moratalla R.
Movement Disorders : Official Journal of the Movement Disorder Society 2017 Aug; 32(10):1409.
Application：WB-Ce, Human, Human skin fibroblasts.
- Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis.
Benitez BA, Sands MS.
Scientific Reports 2017 Jul; 7(1):6332.
Application：WB-Ce, Mouse, N2A cells.
- Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis.
Santarino IB, Viegas MS, Domingues NS, Ribeiro AM, Soares MP, Vieira OV.
Scientific Reports 2017 Jul; 7(1):5812.
Application：WB, Human, Mouse, Human red blood cells (RBC), Mouse RBC.
- Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.
McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME.
Journal of Molecular and Cellular Cardiology 2017 Jul; 110:80.
Application：WB-Ti, Mouse, Mouse hearts.
- O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.
Wani WY, Ouyang X, Benavides GA, Redmann M, Cofield SS, Shacka JJ, Chatham JC, Darley-Usmar V, Zhang J.
Molecular Brain 2017 Jul; 10(1):32.
Application：WB, Rat, DIV7 primary rat cortical neurons.
- Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy.
Joachim J, Razi M, Judith D, Wirth M, Calamita E, Encheva V, Dynlacht BD, Snijders AP, O'Reilly N, Jefferies HBJ, Tooze SA.
Current Biology : CB 2017 Jul; 27(14):2123.
Application：WB, Human, HEK 293A cells.
- Bacteroides fragilis Enterotoxin Induces the Formation of Autophagosomes in Endothelial Cells but Interferes Their Autophagosomal Fusion with Lysosomes for Complete Autophagic Flux Through a Mitogen-Activated Protein Kinase, AP-1, and C/EBP Homologous Protein-Dependent Pathway.
Ko SH, Jeon JI, Myung HS, Kim YJ, Kim JM.
Infection and Immunity 2017 Sep; 85(10):e00420-17.
Application：IF, WB-Ce, WB-Tr, Human, CRL1730 cells, HUVEC.
- Unbiased proteomics of early Lewy body formation model implicates active microtubule affinity-regulating kinases (MARKs) in synucleinopathies.
Henderson MX, Chung CH, Riddle DM, Zhang B, Gathagan RJ, Seeholzer SH, Trojanowski JQ, Lee VMY.
Journal of Neuroscience 2017 Jun; 7(24):5870.
Application：IF, WB, Human, Mouse, Human synucleinopathy tissue, Mouse hippocampus.
- A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity.
Schnettger L, Rodgers A, Repnik U, Lai RP, Pei G, Verdoes M, Wilkinson RJ, Young DB, Gutierrez MG.
Cell Host & Microbe 2017 May; 21(5):619.
Application：IF, Mouse, Mouse bone marrow macrophages.
- Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy.
Zhang Y, Nguyen DT, Olzomer EM, Poon GP, Cole NJ, Puvanendran A, Phillips BR, Hesselson D.
Cell Chemical Biology 2017 Apr; 24(4):471.
Application：WB, Human, SH-SY5Y cells.
- Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.
Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, Lee VM.
Amino Acids 2017 Dec; 43(7):604.
Application：IF, Human, Brain from patients with Parkinson's disease.
- Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.
Lee EB, Porta S, Michael Baer G, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM, Irwin DJ, Van Deerlin VM, Trojanowski JQ.
Acta Neuropathologica 2017 Jan; [Epub].
Application：IF, Human, Brain from patients with Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP).
- Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.
Redmann M, Wani WY, Volpicelli-Daley L, Darley-Usmar V, Zhang J.
Redox Biology 2017 Jan; 11:429.
Application：WB, Mouse, primary cortical neurons.
- The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
Luis H Franco, Vidhya R Nair, Caitlyn R Scharn, Ramnik J Xavier, Jose R Torrealba, Michael U Shiloh, Beth Levine.
Cell Host & Microbe 2017 Jan; 21(1):59.
Application：IF, Mouse, Mouse bone-marrow-derived macrophages.
- Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.
Haldar AK, Piro AS, Finethy R, Espenschied ST, Brown HE, Giebel AM, Frickel EM, Nelson DE, Coers J.
mBio 2016 Dec; 7(6).
Application：ICC, IF, Human, A-549 cells.
- Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A.
EMBO Molecular Medicine 2017 Jan; 9(1):112.
Application：WB, Mouse, Mouse brain.
- Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons.
Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM Zhang J.
Redox Biology 2016 Nov; 11:73.
Application：WB, Rat, Primary cortical rat neurons.
- Turnover of Lipidated LC3 and Autophagic Cargoes in Mammalian Cells.
Rodríguez-Arribas M, Yakhine-Diop SMS, González-Polo RA, Niso-Santano M, Fuentes JM.
Amino Acids 2016 Nov; 587:55.
Application：WB, Mouse, MEF cells.
- Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line.
Aydinlik S, Erkisa M, Cevatemre B, Sarimahmut M, Dere E, Ari F, Ulukaya E.
Biochimica et Biophysica Acta 2016 Nov; 1861(2):49.
Application：WB, Human, MDA-MB-231.
- Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells.
Zhou Y, Li Y, Ni HM, Ding WX, Zhong H.
Toxicology and Applied Pharmacology 2016 Sep; 310:140.
Application：WB, Human, A549, HCC827 cells.
- Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis.
Conlon DM, Thomas T, Fedotova T, Hernandez-Ono A, Di Paolo G, Chan RB, Ruggles K, Gibeley S, Liu J, Ginsberg HN.
The Journal of Clinical Investigation 2016 Sep; 126(10):3852.
Application：WB, Mouse, Mouse liver.
- Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors.
Jin HO, Hong SE, Park JA, Chang YH, Hong YJ, Park IC, Lee JK.
Scientific Reports 2016 Jun; 6:28945.
Application：WB-Ce, Human, H460 cells.
- Measuring Autophagy in the Context of Cancer.
Morgan MJ, Thorburn A.
Advances in Experimental Medicine and Biology 2016 Jun; 899:121.
Application：WB-Tr, Human, T24t cells.
- A Cell-Based Quantitative High-Throughput Image Screening Identified Novel Autophagy Modulators.
Li Y, McGreal S, Zhao J, Huang R, Zhou Y, Zhong H, Xia M, Ding WX.
Pharmacological Research 2016 May; 110:35.
- Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.
Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, Konig T, Kukat A, Trifunovic A.
EMBO Reports 2016 Jul; 17(7):953.
Application：WB-Ti, Mouse, Heart.
- Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.
Jie Jiang, Qiang Zhu, Tania F Gendron, Shahram Saberi, Melissa McAlonis-Downes, Amanda Seelman, Jennifer E Stauffer, Paymaan Jafar-Nejad, Kevin Drenner, Derek Schulte, Seung Chun, Shuying Sun, Shuo-Chien Ling, Brian Myers, Jeffery Engelhardt, Melanie Katz, Michael Baughn, Oleksandr Platoshyn, Martin Marsala, Andy Watt, Charles J Heyser, M Colin Ard, Louis De Muynck, Lillian M Daughrity, Deborah A Swing, Lino Tessarollo, Chris J Jung, Arnaud Delpoux, Daniel T Utzschneider, Stephen M Hedrick, Piet
Neuron 2016 May; 90(3):535.
Application：IF, Mouse, Cotex.
- Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin-deficient mice.
de Luxan-Delgado B, Potes Y, Rubio-Gonzalez A, Caballero B, Solano JJ, Fernandez-Fernandez M, Bermudez M, Rodrigues Moreira Guimaraes M, Vega-Naredo I, Boga JA, Coto-Montes A.
Journal of Pineal Research 2016 Jun; 61(1):108.
Application：WB, Mouse, Mouse liver.
- Biotinylation: A novel posttranslational modification linking cell autonomous circadian clocks with metabolism.
He L, Hamm JA, Reddy A, Sams D, Peliciari-Garcia RA, McGinnis GR, Bailey SM, Chow CW, Rowe GC, Chatham JC, Young ME.
American Journal of Physiology. Heart and Circulatory Physiology 2016 Apr; 310(11):H1520.
Application：WB, Mouse, Mouse heart.
- Molecular Targets for ALS and Related Disorders.
Siddique T, Chen W, Deng H, Yang Y.
United States Patent Application 2016 Mar; US20160076102A1.
Application：IHC-P, Human, Spinal motor neuron.
- A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome.
Winner LK, Beard H, Hassiotis S, Lau AA, Luck AJ, Hopwood JJ, Hemsley KM.
Human Gene Therapy 2016 May; 27(5):363.
Application：IHC-P, Mouse, Brain.
- Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice.
Wilson CH, Nikolic A, Kentish SJ, Shalini S, Hatzinikolas G, Page AJ, Dorstyn L, Kumar S.
Cell Death Discovery 2016 Feb; 2:16009.
Application：WB-Ti, Mouse, Liver, Muscle.
- Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.
Sydow A, Hochgräfe K, Könen S, Cadinu D, Matenia D, Petrova O, Joseph M, Dennissen F, Mandelkow EM.
Acta Neuropathologica Communications 2016 Feb; 4(1):17.
Application：WB-Ti, Mouse, Cortex.
- Oncolytic adenovirus loaded with L-carnosine as novel strategy to enhance the anti-tumor activity.
Garofalo M, Iovine B, Kuryk L, Capasso C, Hirvinen M, Vitale A, Ylippertula M, Bevilacqua MA, Cerullo V.
Molecular Cancer Therapeutics 2016 Feb; 15(4):651.
Application：WB-Ce, Human, A549,Hct116.
- Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger HG, Quirós PM, López-Otín C, Rugarli EI, Langer T.
The Journal of Cell Biology 2016 Jan; 212(2):157.
Application：WB-Ti, Mouse, Hippocampal.
- FGF signalling regulates bone growth through autophagy.
Cinque L, Forrester A, Bartolomeo R, Svelto M, Venditti R, Montefusco S, Polishchuk E, Nusco E, Rossi A, Medina DL, Polishchuk R, De Matteis MA, Settembre C.
Nature 2015 Dec; 528(7581):272.
Application：WB-Ce, Mouse, Chondrocytes.
- Autophagy mediates degradation of nuclear lamina.
Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Daniel Ricketts M, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL.
Nature 2015 Nov; 527:105.
Application：WB, Human, IMR90, HEK293T cells.
- Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling.
Nemazanyy I, Montagnac G, Russell RC, Morzyglod L, Burnol AF, Guan KL, Pende M, Panasyuk G.
Nature Communications 2015 Sep; 6:8283.
- Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.
LaPash Daniels CM, Paffenroth E, Austin EV, Glebov K, Lewis D, Walter J, Messing A.
PLoS One 2015 Sep; 10(9):e0138132.
Application：WB, Mouse, Brain.
- Parkin Regulates Mitophagy and Mitochondrial Function to Protect Against Alcohol-induced Liver Injury and Steatosis in Mice.
Williams JA, Ni HM, Ding Y, Ding WX.
American Journal of Physiology. Gastrointestinal and Liver Physiology. 2015 Sep; 309(5):G324.
Application：WB-Ti, Mouse, Liver.
- Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.
Yang H, Peng YF, Ni HM, Li Y, Shi YH, Ding WX, Fan J.
PLoS One 2015 Jun; 10(6):e0130953.
Application：WB-Ce, Human, SMMC-7721, HepG2, HCC97-L, HCC-LM3 cells.
- Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.
Andrew A Wilson, Lei Ying, Marc Liesa, Charis-Patricia Segeritz, Jason A Mills, Steven S Shen, Jyhchang Jean, Geordie C Lonza, Derek C Liberti, Alex H Lang, Jean Nazaire, Adam C Gower, Franz-Josef Müeller, Pankaj Mehta, Adriana Ordóñez, David A Lomas, Ludovic Vallier, George J Murphy, Gustavo Mostoslavsky, Avrum Spira, Orian S Shirihai, Maria I Ramirez, Paul Gadue, Darrell N Kotton.
Stem Cell Reports 2015 May; 4(5):873.
Application：WB-Ce, Human, iPSC cells.
- Drosha Inclusions Are New Components of Dipeptide-Repeat Protein Aggregates in FTLD-TDP and ALS C9orf72 Expansion Cases.
Porta S, Kwong LK, Trojanowski JQ, Lee VM.
Journal of Neuropathology and Experimental Neurology 2015 Apr; 74(4):380.
Application：IF, Human, Brain.
- Streptococcus pneumoniae Induces Autophagy through the Inhibition of the PI3K-I/Akt/mTOR Pathway and ROS Hypergeneration in A549 Cells.
Li P, Shi J, He Q, Hu Q, Wang YY, Zhang LJ, Chan WT, Chen WX.
PLoS One 2015 Mar; 10(3):e122753.
Application：WB-Ce, Human, Streptococcus pneumoniae infection in A549 cells.
- 3D Bioprinting of Biomimetic Aortic Vascular Constructs with Self-Supporting Cells.
Kucukgul C, Ozler SB, Inci I, Karakas E, Irmak S, Gozuacik D, Taralp A, Koc B.
Biotechnology and Bioengineering 2015 Apr; 112(4):811.
Application：WB, Mouse, MEFs.
- Unsaturated fatty acids induce non-canonical autophagy.
Niso-Santano M, Malik SA, Pietrocola F, Bravo-San Pedro JM, Marino G, Cianfanelli V, Ben-Younes A, Troncoso R, Markaki M, Sica V, Izzo V, Chaba K, Bauvy C, Dupont N, Kepp O, Rockenfeller P, Wolinski H, Madeo F, Lavandero S, Codogno P, Harper F, Pierron G, Tavernarakis N, Cecconi F, Maiuri MC, Galluzzi L, Kroemer G.
The EMBO Journal 2015 Apr; 34(8):1025.
Application：IF, WB, WB-Tr, WB-Ti, Human, Mouse, U2OS, HeLa cells.
- Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice.
Ni HM, Bhakta A, Wang S, Li Z, Manley S, Huang H, Copple B, Ding WX.
PLoS One 2014 Dec; 9(12):e115849.
Application：WB-Ti, Mouse, Liver.
- Caspase-2 protects against oxidative stress in vivo.
Shalini S, Puccini J, Wilson CH, Finnie J, Dorstyn L, Kumar S.
Oncogene 2015 Sep; 34(38):4995.
Application：WB-Ti, Mouse, Lung.
- IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells.
Chang MA, Patel V, Gwede M, Morgado M, Tomasevich K, Fong EL, Farach-Carson MC, Delk NA.
Journal of cellular biochemistry 2014 Dec; 115(12):2188.
Application：IF, WB-Ce, Human, C4-2 cells.
- Graphene oxide as a chemosensitizer: Diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects.
Chen GY, Meng CL, Lin KC, Tuan HY, Yang HJ, Chen CL, Li KC, Chiang CS, Hu YC.
Biomaterials 2015 Feb; 40:12.
Application：IF, Mouse, CT26 cells.
- Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation.
Fawzi AA, Simonett JM, Purta P, Moss HE, Lowry JL, Deng HX, Siddique N, Sufit R, Bigio EH, Volpe NJ, Siddique T.
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration 2014 Dec; 15(7-8):569.
Application：IF, Human, Retina.
- Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, Gallazzini M, Olson EN, Lam H, Henske EP, Dong Z, Apte U, Pallet N, Johnson RL, Terzi F, Kwiatkowski DJ, Scoazec JY, Martignoni G, Pende M.
The Journal of Experimental Medicine 2014 Oct; 211(11):2249.
Application：IP-WB, WB-Ti, Human, Mouse, HeLa cells, Kidney.
- Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity.
Manley S, Ni HM, Williams JA, Kong B, DiTacchio L. Guo G, Ding WX.
Redox Biology 2014 Aug; 2:991.
Application：WB, Mouse, Liver.
- Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability.
Bharath LP, Mueller R, Li Y, Ruan T, Kunz D, Goodrich R, Mills T, Deeter L, Sargsyan A, Anandh Babu PV, Graham TE, Symons JD.
Canadian Journal of Physiology and Pharmacology 2014 Jul; 92(7):605.
Application：WB-Ce, Bovine, Bovine aortic endothelial cells.
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC.
Nature 2014 May; 509(7498):105.
Application：WB-Ce, Human, MCF-7 cells.
- Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart.
Jacqueline Thorburn, Zdenek Andrysik, Leah Staskiewicz, Jacob Gump, Paola Maycotte, Andrew Oberst, Douglas R Green, Joaquín M Espinosa, Andrew Thorburn.
Cell Reports 2014 Mar; 7(1):45.
Application：WB, Human, HeLa cells.
- Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation.
B'chir W, Chaveroux C, Carraro V, Averous J, Maurin AC, Jousse C, Muranishi Y, Parry L, Fafournoux P, Bruhat A.
Cellular Signalling 2014 Jul; 26(7):1385.
Application：WB-Ce, Mouse, MEFs.
- Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation.
MacVicar TD, Lane JD.
Journal of Cell Science 2014 May; 127(Pt 10):2313.
Application：IF, Human, RPE1 cells.
- Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.
Sukru Anil Dogan, Claire Pujol, Priyanka Maiti, Alexandra Kukat, Shuaiyu Wang, Steffen Hermans, Katharina Senft, Rolf Wibom, Elena I Rugarli, Aleksandra Trifunovic.
Cell Metabolism 2014 Mar; 19(3):458.
Application：IF, WB, Mouse, Mouse heart, Mouse skeletal muscle.
- Defective autophagy impairs ATF3 activity and worsens lung injury during endotoxemia.
Aguirre A, Lopez-Alonso I, Gonzalez-Lopez A, Amado-Rodriguez L, Batalla-Solis E, Astudillo A, Blazquez-Prieto J, Fernandez AF, Galvan JA, Dos Santos CC, Albaiceta GM.
Journal of Molecular Medicine 2014 Jun; 92(6):665.
Application：WB, Human, BEAS-2b cells.
- Excitotoxic glutamate insults block autophagic flux in hippocampal neurons.
Kulbe JR, Mulcahy Levy JM, Coultrap SJ, Thorburn A, Ulrich Bayer K.
Brain Research 2014 Jan; 1542:12.
Application：WB-Ce, Rat, Hippocampal cells.
- The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome.
Jones S, Cunningham DL, Rappoport JZ, Heath JK.
Journal of Cell Science 2014 Mar; 27(Pt 5):994.
Application：IF, WB-Ce, Human, HeLa, LNCaP cells.
- MIR376A Is a Regulator of Starvation-Induced Autophagy.
Korkmaz G, Tekirdag KA, Ozturk DG, Kosar A, Sezerman OU, Gozuacik D.
PLoS One 2013 Dec; 8(12):e82556.
Application：WB, Human, MCF-7 cells.
- Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
Gump JM, Staskiewicz L, Morgan MJ, Bamberg A, Riches DW, Thorburn A.
Nature Cell Biology 2014 Jan; 16(1):47.
Application：WB, Human, BJAB, Jurkat cells.
- Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Liu Y, Shoji-Kawata S, Sumpter RM Jr, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B.
PNAS 2013 Dec; 110(51):20364.
Application：WB-Ce, WB-Tr, Human, HeLa, U2OS cells.
- Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation.
de Luxan-Delgado B, Caballero B, Potes Y, Rubio-Gonzalez A, Rodriguez I, Gutierrez-Rodriguez J, Solano JJ, Coto-Montes A.
Journal of Pineal Research 2014 Mar; 56(2):126.
Application：WB-Ti, Mouse, Liver.
- New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy.
Li L, Wang ZV, Hill JA, Lin F.
Journal of the American Society of Nephrology 2014 Feb; 25(2):305.
Application：IF, Mouse, Renal epithelial cells.
- C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.
Mizielinska S, Lashley T, Norona FE, Clayton EL, Ridler CE, Fratta P, Isaacs AM.
Acta Neuropathologica 2013 Dec; 126(6):845.
Application：IS, Human, Brain.
- Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients.
Tardif N, Klaude M, Lundell L, Thorell A, Rooyackers O.
The American Journal of Clinical Nutrition 2013 Dec; 98(6):1485.
Application：WB-Ti, Human, Muscle.
- Impairment of Autophagic Flux Promotes Glucose Reperfusion-Induced Neuro2A Cell Death after Glucose Deprivation.
Jang BG, Choi BY, Kim JH, Kim MJ, Sohn M, Suh SW.
PLoS One 2013 Oct; 8(10):e76466.
Application：WB-Ce, Mouse, Neuro2a cells.
- Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis.
Devereaux K.
PLoS One 2013 Oct; 8(10):e76405.
Application：IS, WB-Tr, Mouse, MEFs.
- Critical Role of FoxO3a in Alcohol-Induced Autophagy and Hepatotoxicity.
Ni HM, Du K, You M, Ding WX.
The American Journal of Pathology 2013 Dec; 183(6):1815.
Application：WB-Ce, Mouse, Hepatocytes.
- p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines.
Chang MA, Morgado M, Warren CR, Hinton CV, Farach-Carson MC, Delk NA.
The Prostate 2014 Feb; 74(2):149.
Application：IF, WB-Ce, Human, C4-2, C4-2B, MDAPCa 2a, MDAPCa2b, VCaPPCa, PC3, DU145 cells.
- REACTIVE OXYGEN SPECIES REGULATION OF AUTOPHAGY IN SKELETAL MUSCLES.
Rahman M, Mofarrahi M, Kristof AS, Nkengfac B, Harel S, Hussain S Dr.
Antioxidants & Redox Signaling 2014 Jan; 20(3):443.
Application：WB, Mouse, Mouse muscle.
- The ubiquitin ligase parkin mediates resistance to intracellular pathogens.
Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS.
Nature Research 2013 Sep; 501(7468):512.
Application：IF, Mouse, BMDMs.
- The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression.
B'chir W, Maurin AC, Carraro V, Averous J, Jousse C, Muranishi Y, Parry L, Stepien G, Fafournoux P, Bruhat A.
Nucleic Acids Research 2013 Sep; 41(16):7683.
Application：WB, Mouse, MEFs.
- Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation.
Tung YT, Wang BJ, Hsu WM, Hu MK, Her GM, Huang WP, Liao YF.
Molecular Neurobiology 2014 Feb; 49(1):10.
Application：WB-Ce, WB-Tr, Human, Mouse, HEK 293, SH-SY5Y cells, MEFs.
- Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway.
Sandri M, Barberi L, Bijlsma AY, Blaauw B, Dyar KA, Milan G, Mammucari C, Meskers CG, Pallafacchina G, Paoli A, Pion D, Roceri M, Romanello V, Serrano AL, Toniolo L, Larsson L, Maier AB, Munoz-Canoves P, Musaro A, Pende M, Reggiani C, Rizzuto R, Schiaffino S.
Biogerontology 2013 Jun; 14(3):303.
Application：WB-Ti, Human, Skeletal muscle.
- Impairment of autophagy decreases ventilator-induced lung injury by blockade of the NFκB pathway.
Lopez-Alonso I, Aguirre A, Gonzalez-Lopez A, Fernandez AF, Amado-Rodriguez L, Astudillo A, Batalla-Solis E, Albaiceta GM.
American Journal of Physiology. Lung Cellular and Molecular Physiology 2013 Jun; 304(12):L844.
Application：WB-Ti, Mouse, Mouse lungs.
- RalGDS-Dependent Cardiomyocyte Autophagy is Required for Load-Induced Ventricular Hypertrophy.
Rifki OF, Bodemann BO, Battiprolu PK, White MA, Hill JA.
Journal of Molecular and Cellular Cardiology 2013 Jun; 59:128.
Application：WB-Tr, Mouse, Neonatal rat cardiomyocytes.
- p62/SQSTM1 Enhances NOD2-Mediated Signaling and Cytokine Production through Stabilizing NOD2 Oligomerization.
Park S, Ha SD, Coleman M, Meshkibaf S, Kim SO.
PLoS One 2013 Feb; 8(2):e57138.
Application：WB, Human, HEK293 cells.
- Site-specific Mtm1 mutagenesis by an AAV-Cre vector reveals that myotubularin is essential in adult muscle.
Joubert R, Vignaud A, Le M, Moal C, Messaddeq N, Buj-Bello A.
Human Molecular Genetics 2013 May; 22(9):1856.
Application：WB, Mouse, Mouse muscle.
- Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.
Maccallum SF, Groves MJ, James J, Murray K, Appleyard V, Prescott AR, Drbal AA, Nicolaou A, Cunningham J, Haydock S, Ganley IG, Westwood NJ, Coates PJ, Lain S, Tauro S.
Scientific Reports 2013 Feb; 3:1275.
Application：WB, Human, CLL cells.
- Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration.
Crabtree D, Boyer-Guittaut M, Ouyang X, Fineberg N, Zhang J.
Neuroscience Letters 2013 Mar; 538:3.
Application：WB, Mouse, Brain.
- Host Cell Autophagy Modulates Early Stages of Adenovirus Infections in Airway Epithelial Cells.
Zeng X, Carlin CR.
Journal of Virology 2012 Dec; 87(4):2307.
Application：WB-Ce, Human, HEK-293.
- Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.
Gan L, Vargas MR, Johnson DA, Johnson JA.
The Journal of Neuroscience 2012 Dec; 32(49):17775.
Application：IF, WB-Ti, Mouse, Brain.
- Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis.
Pan JA, Fan Y, Gandhirajan RK, Madesh M, Zong WX.
Journal of Biological Chemistry 2012 Dec; 288(5):2952.
Application：WB-Ce, Rat, MDEG cell.
- Suppression of Autophagic Flux by Bile Acids in Hepatocytes.
Manley S, Ni HM, Kong B, Apte U, Guo G, Ding WX.
Toxicological Sciences 2013 Nov; 137(2):478.
Application：WB, Mouse, Mouse livers, hepatocyte.
- Defective autophagy and mTORC1 signaling in myotubularin null mice.
Fetalvero KM, Yu Y, Goetschkes M, Liang G, Valdez RA, Gould T, Triantafellow E, Bergling S, Loureiro J, Eash J, Lin V, Porter JA, Finan PM, Walsh K, Yang Y, Mao X, Murphy LO.
Molecular and Cellular Biology 2013 Jan; 33(1):98.
Application：WB-Ti, Mouse, Brains, Hearts, Livers, Muscles.
- Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration.
Liao CC, Ho MY, Liang SM, Liang CM.
Autophagy 2012 Oct; 9(1):5.
Application：WB-Ce, Rat, RAW264.7 cell.
- (-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization.
Zhang Y, Yang ND, Zhou F, Shen T, Duan T, Zhou J, Shi Y, Zhu XQ, Shen HM.
PLoS One 2012 Oct; 7(10):e46749.
Application：WB-Ce, Human, Mouse, HepG2 cells, MEFs.
- Sorafenib has potent antitumor activity against multiple myeloma in vitro, ex vivo, and in vivo in the 5T33MM mouse model.
Kharaziha P, De Raeve H, Fristedt C, Li Q, Gruber A, Johnsson P, Kokaraki G, Panzar M, Laane E, Osterborg A, Zhivotovsky B, Jernberg-Wiklund H, Grandér D, Celsing F, Björkholm M, Vanderkerken K, Panaretakis T.
Cancer Research 2012 Oct; 72(20):5348.
Application：WB-Ce, Human, 8226, H929,LP-1, OPM2, U266 cells.
- West Nile virus (WNV) replication is independent of autophagy in mammalian cells.
Vandergaast R, Fredericksen BL.
PLoS One 2012 Sep; 7(9):e45800.
Application：WB-Ce, Mouse, Neuro2A cells.
- Rotenone inhibits autophagic flux prior to inducing cell death.
Mader BJ, Pivtoraiko VN, Flippo HM, Klocke BJ, Roth KA, Mangieri LR, Shacka JJ.
ACS Chemical Neuroscience 2012 Dec; 3(12):1063.
Application：WB-Ce, Human, SH-SY5Y cells.
- Tissue specific induction of p62/Sqstm1 by farnesoid X receptor.
Williams JA, Thomas AM, Li G, Kong B, Zhan L, Inaba Y, Xie W, Ding WX, Guo GL.
PLoS One 2012 Aug; 7(8):e43961.
Application：WB-Ti, Mouse, Mouse ileum and liver.
- Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival.
Hagemann TL, Jobe EM, Messing A.
PLoS One 2012 May; 7(5):e37304.
Application：IHC-Fr, WB-Ti, Mouse, Mouse brain.
- MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network.
Marchbank K, Waters S, Roberts RG, Solomon E, Whitehouse CA.
International Journal of Cell Biology 2012 May; 2012:208014.
Application：WB, Rat, PC-12 cells.
- Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX.
Toxicological Sciences 2012 Jun; 127(2):438.
Application：WB-Ti, Mouse, Mouse liver.
- A centronuclear myopathy--dynamin 2 mutation impairs autophagy in mice.
Durieux AC, Vassilopoulos S, Lainé J, Fraysse B, Briñas L, Prudhon B, Castells J, Freyssenet D, Bonne G, Guicheney P, Bitoun M.
Traffic 2012 Jun; 13(6):869.
Application：IF, WB-Ti, Mouse, MEFs, Liver, Tibialis anterior muscles.
- Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD.
Science Signaling 2012 Mar; 5(217):ra24.
Application：WB-Ti, Mouse, Liver.
- Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.
Ghazi-Noori S, Froud KE, Mizielinska S, Powell C, Smidak M, Fernandez de Marco M, O'Malley C, Farmer M, Parkinson N, Fisher EM, Asante EA, Brandner S, Collinge J, Isaacs AM.
Brain 2012 Mar; 135(Pt 3):819.
Application：WB-Ti, Mouse, Brain.
- Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells.
Kharaziha P, Rodriguez P, Li Q, Rundqvist H, Bjorklund AC, Augsten M, Ullen A, Egevad L, Wiklund P, Nilsson S, Kroemer G, Grander D, Panaretakis T.
Cell Death & Disease 2012 Jan; 3:e262.
Application：WB, Human, Impaired elderly humans.
- Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function.
Jaber N, Dou Z, Chen JS, Catanzaro J, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin RZ, Zhang J, Zong WX.
PNAS 2012 Feb; 109(6):2003.
Application：WB-Ce, WB-Ti, Mouse, Hepatocytes, Livers, MEFs.
- Cathepsin Cleavage of Sirtuin-1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence.
Chen J, Xavier S, Moskowitz-Kassai E, Chen R, Lu CY, Sanduski K, Spes A, Turk B, Goligorsky MS.
The American Journal of Pathology 2012 Jan; 180(3):973.
Application：WB, Mouse, Mouse endothelial progenitor cells.
- Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Kruger U, Wang Y, Kumar S, Mandelkow EM.
Neurobiology of Aging 2011 Dec; 33(10):2291.
Application：WB-Ce, Rat, Rat cortical neurons.
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen GH, Donkervoort S, Bigio EH, Brooks BR, Ajroud K, Sufit RL, Haines JL, Mugnaini E, Pericak-Vance MA, Siddique T.
Nature 2011 Aug; 477(7363):211.
Application：IF, IHC-P, Human, Human brains.
- Modulation of pediatric brain tumor autophagy and chemosensitivity.
Levy JM, Thorburn A.
Journal of Neuro-Oncology 2012 Jan; 106(2):281.
Application：WB-Ce, Human, BT-16, Daoy cells.
- Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery.
Kovacs JR, Li C, Yang Q, Li G, Garcia IG, Ju S, Roodman DG, Windle JJ, Zhang X, Lu B.
Cell Death and Differentiation 2012 Jan; 19(1):144.
Application：IP-WB, WB-Ce, WB-Tr, Mouse, CD4+ T cells.
- Pancreatic cancers require autophagy for tumor growth.
Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC.
Genes & Development 2011 Apr; 25(7):717.
Application：IHC, WB, Mouse, Pancreatic tumors.
- Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.
Whitehouse CA, Waters S, Marchbank K, Horner A, McGowan NW, V Jovanovic J, Xavier GM, Kashima TG, Cobourne MT, Richards GO, Sharpe PT, Skerry TM, Grigoriadis AE, Solomon E.
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul; 107(29):12913.
Application：IF, WB-Tr, Mouse, MEFs, Mouse osteoblasts.
- 14-3-3Tau regulates Beclin 1 and is required for autophagy.
Wang B, Ling S, Lin WC.
PLoS One 2010 Apr; 5(4):e10409.
Application：WB, Human, U2OS cells.
- In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells.
Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A.
Immunity 2010 Feb; 32(2):227.
Application：WB-Ce, Mouse, Dendritic cells.
- Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase.
Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM.
The Journal of Biological Chemistry 2010 Apr; 285(14):10850.
Application：WB, Mouse, L929 cells, MEFs.
- Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.
Mardakheh FK, Yekezare M, Machesky LM, Heath JK.
The Journal of Cell Biology 2009 Oct; 187(2):265.
Application：WB-Ce, Human, 293T cell.
- Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.
Ferguson CJ, Lenk GM, Meisler MH.
Human Molecular Genetics 2009 Dec; 18(24):4868.
Application：ICC, IF, Mouse, Brain.
- Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.
Gal J, Strom AL, Kwinter DM, Kilty R, Zhang J, Shi P, Fu W, Wooten MW, Zhu H.
Journal of Neurochemistry 2009 Nov; 111(4):1062.
Application：IP, WB-Ti, Mouse, Transgenic mouse spinal cords.
- Monitoring autophagic degradation of p62/SQSTM1.
Bjørkøy G, Lamark T, Pankiv S, Øvervatn A, Brech A, Johansen T.
Methods in Enzymology 2009 N/A; 452:181.
- Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia.
Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, Jeong YT, Han MS, Lee MK, Kim KW, Shin J, Lee MS.
Cell Metabolism 2008 Oct; 8(4):318.
Application：IF, IHC, Mouse, Mouse pancreatic tissues.
- NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.