Torc1 (Ser151) Polyclonal Antibody, APC-Cy7 Conjugated
Referencia bs-3453R-APC-Cy7
embalaje : 100ul
Marca : Bioss
Torc1 (Ser151) Polyclonal Antibody, APC-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-3453R-APC-Cy7 |
Product Name | Torc1 (Ser151) Polyclonal Antibody, APC-Cy7 Conjugated |
Applications | WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
Specificity | Due to the highly conserved nature of this protein, this antibody will react with Torc3 when phosphorylated at Ser162 across the listed species due to homology. |
Reactivity | Human, Chicken |
Predicted Reactivity | Mouse, Rat, Dog, Cow, Pig, Horse, Rabbit |
Specifications | |
Conjugation | APC-Cy7 |
Host | Rabbit |
Source | KLH conjugated synthetic phosphopeptide derived from human Torc1 around the phosphorylation site of Ser151 |
Modification Site | Ser151 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 23373 |
Swiss Prot | Q6UUV9 |
Subcellular location | Cytoplasm, Nucleus |
Synonyms | MECT1; TORC1; TORC-1; WAMTP1; CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; Transducer of CREB protein 1; CRTC1; KIAA0616 |
Background | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. |
Application Dilution | |
WB | 1:300-5000 |
IF(IHC-P) | 1:50-200 |
IF(IHC-F) | 1:50-200 |
IF(ICC) | 1:50-200 |