VHL probe for ISH CE/IVD - Kidney cancer

VHL probe for ISH CE/IVD - Kidney cancer

 

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. It is estimated that about 1 in 30,000 people has VHL. About 20% of people with VHL do not have any family history of the condition. They have a de novo mutation, meaning a new mutation in the VHL gene.

 

 

Resultados de su búsqueda : 3 Producto encontrado

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RUOCE / IVD
  • Green-Orange 1
  • Green-Red-Gold-Blue 1
  • Probe
  • ISH 3
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Referencia
Descripción
Cond.
Precio Sin IVA
Z-2084-200
 0,2ml/20tests 
VHL-20-OR
 20Tests-40µl