Anti-NOV/CCN3 Antibody (5D628)
Referencia NB-64-121779-100uL
embalaje : 100uL
Marca : Neo Biotech
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Anti-NOV/CCN3 Antibody (5D628)
(Synonyms: nephroblastoma overexpressed) Copy Product InfoSynonyms: nephroblastoma overexpressed
Catalog No. TMAY-00538 Copy Product Info
Anti-NOV/CCN3 Antibody (5D628) is a Rabbit antibody targeting NOV/CCN3. Anti-NOV/CCN3 Antibody (5D628) can be used in ELISA.
For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-NOV/CCN3 Antibody (5D628) is a Rabbit antibody targeting NOV/CCN3. Anti-NOV/CCN3 Antibody (5D628) can be used in ELISA. |
| Synonyms | nephroblastoma overexpressed |
| Ig Type | Rabbit IgG |
| Clone | 5D628 |
| Reactivity | Human |
| Specificity | Human NOV/CCN3 No cross-reactivity in ELISA with Human WISP1 |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CCN3 / NOV / IGFBP9 (rh CCN3 / NOV / IGFBP9; TMPY-01307; NP_002505.1; Met 1-Met 357). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is a putative ligand for integrin receptors, is tightly associated with the extracellular matrix, and mediates diverse cellular functions, including cell adhesion and proliferation. CCN3 has been shown to negatively regulate growth although it promotes migration in a cell type-specific manner. This secreted protein belongs to the CCN family, and its expression was observed in a broad variety of tissues from the early stage of development, and altered expression of CCN3 has been observed in a variety of tumors, including hepatocellular carcinomas, Wilm's tumors, Ewing's sarcomas, gliomas, rhabdomyosarcomas, and adrenocortical carcinomas. Mature CCN3 protein has five distinct modules and truncated protein variants with altered function are found in many cancers. CCN3 acts through the core stem cell signaling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of some cell lineages including hematopoietic, osteogenic, and chondrogenic. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis, and a crucial component within the bone marrow microenvironment. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CCN3 / NOV / IGFBP9 Protein (TMPY-01307) |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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