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> Frizzled 6 Protein, Human, Recombinant (His)

Frizzled 6 Protein, Human, Recombinant (His)

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Frizzled 6 Protein, Human, Recombinant (His)

(Synonyms: NDNC10, HFZ6, FZ-6, FZ6, frizzled class receptor 6) Copy Product Info

Synonyms: NDNC10, HFZ6, FZ-6, FZ6, frizzled class receptor 6

Catalog No. TMPY-04271 Copy Product Info
Frizzled 6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is A0A024R9E9.
Other Forms of Frizzled 6 Protein, Human, Recombinant (His):
Frizzled 6 Protein, Human, Recombinant (mFc)TMPY-00577
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For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Frizzled 6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is A0A024R9E9.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberO60353
ConstructionA DNA sequence encoding the human FZD6 (NP_003497.2) (Met1-Val153) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: His 19
Protein Purity
> 95 % as determined by SDS-PAGE.
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
SynonymsNDNC10, HFZ6, FZ-6, FZ6, frizzled class receptor 6
Research Background
FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolated nail anomaly manifesting with onychauxis and onycholysis is a rare condition, caused by mutations in the gene FZD6, encoding membrane-bound Wnt receptor protein. The overexpression of FZD6 may play an important role in the development of Colorectal cancer (CRC). FZD6 repressed gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. FZD6 plays crucial roles in human tumorigenesis.
Chemical Properties
Molecular Weight17.1 kDa (predicted)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

NDNC-10NDNC 10HFZ-6HFZ 6FZ 6
Related Tags: Frizzled 6 Protein, Human, Recombinant (His) chemical structure | Frizzled 6 Protein, Human, Recombinant (His) molecular weight