HRP-Linked Polyclonal Antibody to Retinoic Acid Receptor Alpha (RARa)

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

RARA: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: actin cytoskeleton; cell surface; cytoplasm; nuclear chromatin; nucleoplasm; nucleus

Molecular Function: alpha-actinin binding; chromatin DNA binding; enzyme binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase A binding; protein kinase B binding; receptor binding; retinoic acid binding; retinoic acid receptor activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity; transcription factor binding

Biological Process: apoptotic cell clearance; negative regulation of granulocyte differentiation; negative regulation of interferon-gamma production; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; positive regulation of binding; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; response to retinoic acid; retinoic acid receptor signaling pathway; signal transduction; transcription initiation from RNA polymerase II promoter

Disease: Acute Promyelocytic Leukemia