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MAP4343 [511-26-2]

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Referencia NB-64-45790-10mg

embalaje : 10mg

Marca : Neo Biotech

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MAP4343

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Synonyms:

Catalog No. T9504 Copy Product Info

Purity: 97.02%

Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, resulting in enhanced neurite extension and protection of neurons from neurotoxic agents.

Cas No. 511-26-2

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.02%

Appearance:Solid

Color:White

Product Information

Bioactivity

Description	Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, resulting in enhanced neurite extension and protection of neurons from neurotoxic agents.

Chemical Properties

Molecular Weight	330.5
Formula	C₂₂H₃₄O₂
Cas No.	511-26-2
Smiles	22[C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1(22)[C@@]2(22)CC=C2C[C@H](CC[C@]12C)OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (75.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0257 mL	15.1286 mL	30.2572 mL	151.2859 mL
5 mM	0.6051 mL	3.0257 mL	6.0514 mL	30.2572 mL
10 mM	0.3026 mL	1.5129 mL	3.0257 mL	15.1286 mL
20 mM	0.1513 mL	0.7564 mL	1.5129 mL	7.5643 mL
50 mM	0.0605 mL	0.3026 mL	0.6051 mL	3.0257 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

tubulinproteinPregnenolonepolymerizationneuritesmicrotubule-associated protein 2microtubule-associatedMicrotubuleAssociatedMicrotubule/TubulinMicrotubule AssociatedMAP-4343MAP4343MAP2MAP 4343Inhibitorinhibit

Related Tags: MAP4343 chemical structure | MAP4343 formula | MAP4343 molecular weight