Sodium 2-thiobarbiturate is a nitrosating agent that has been shown to protect the lungs from ischemia–reperfusion injury in vitro. It exerts its protective effects by inhibiting the release of nitric oxide (NO) and protects against neuronal death by preventing mitochondrial dysfunction. Sodium 2-thiobarbiturate also has genotoxic effects, which are reduced in the presence of antioxidants, and can cause DNA damage. This drug is reactive with oxygen, so it should not be stored in airtight containers or exposed to light.
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