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> Alternariol [641-38-3]

Alternariol [641-38-3]

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Referencia orb1707683-1mg

embalaje : 1mg

Marca : Biorbyt


Alternariol

SKU: orb1707683

Description

Alternariol

Research Area

Immunology & Inflammation

Images & Validation

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Alternariol

Key Properties

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CAS Number641-38-3
MW258.23
Purity99.57% (May vary between batches)
FormulaC14H10O5
SMILESO=C1OC2=CC(O)=CC(=C2C=3C=C(O)C=C(O)C13)C
TargetTLR
SolubilityDMSO:20 mg/mL (77.45 mM)

Bioactivity

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In Vivo
Alternariol was administered via intravenous injection (1-5 mg/kg, once daily for 4 consecutive days), demonstrating embryotoxicity and immunotoxicity in mice during embryonic and infant developmental stages, while also triggering apoptosis . In a DMBA-induced breast cancer mouse model, Alternariol (50-200 mg/kg, orally administered once daily for 24 weeks) significantly suppressed breast cancer progression by inducing apoptosis and inhibiting cell proliferation .
In Vitro
Treatment of human lung epithelial cells (BEAS-2B) and mouse macrophages (RAW264.7) with Alternariol (10 μM, 24 h) can inhibit the innate immune response of both cell types . Alternariol (5-10 μM, 24 h) reduces LPS-induced inflammatory response in BEAS-2B cells in a dose-dependent manner . Alternariol (1-100 μM, 24 h) exerts an inhibitory effect on the proliferation of BEAS-2B cells and induces cell cycle arrest . In V79 cells and mouse lymphoma L5178Y tk+/− cells (MLC), Alternariol (10 μM, 24 h) can induce mutations in the HPRT and TK genes .

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Alternariol
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    1. Alternariol-9-methyl Ether

    Alternariol-9-methyl Ether [orb321937]

    ≥98%

    26894-49-5; 23452-05-3

    272.25

    C15H12O5

    1 mg, 5 mg, 0.1 mg
  • Alternariol-trimethylaether

    Alternariol-trimethylaether [orb3159551]

    >=98%

    13872-98-5

    300.3

    C17H16O5

    10 mg
  • Djalonensone

    Djalonensone [orb1683170]

    98.00% (May vary between batches)

    23452-05-3

    272.25

    C15H12O5

    1 mg
  • Alternariol, methyl ether

    Alternariol, methyl ether [orb2563990]

    26894-49-5

    274.23

    C14H10O6

    50 mg, 10 mg
  • Alternariol-trimethylaether

    Alternariol-trimethylaether [orb2653298]

    >98% (HPLC)

    13872-98-5

    300.3

    C17H16O5

    10 mg, 50 mg, 100 mg

Compound Identifiers

PubChem CID
5359485 ↗

Key Properties

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Protocol Information