Anti-Vesicular Acetylcholine Transporter Polyclonal Antibody
Referencia NB-64-114532-100uL
embalaje : 100uL
Marca : Neo Biotech
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Anti-Vesicular Acetylcholine Transporter Polyclonal Antibody
(Synonyms: VACHT, Solute carrier family 18(vesicular monoamine) member 3, Solute carrier family 18(vesicular acetylcholine) member 3, Solute carrier family 18 member 3, SLC18A3, rVAT, MGC12716) Copy Product InfoSynonyms: VACHT, Solute carrier family 18(vesicular monoamine) member 3, Solute carrier family 18(vesicular acetylcholine) member 3, Solute carrier family 18 member 3, SLC18A3, rVAT, MGC12716
Catalog No. TMAB-01960 Copy Product Info
Anti-Vesicular Acetylcholine Transporter Polyclonal Antibody is a Rabbit antibody targeting Vesicular Acetylcholine Transporter. Anti-Vesicular Acetylcholine Transporter Polyclonal Antibody can be used in WB.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Information
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Vesicular Acetylcholine Transporter Polyclonal Antibody is a Rabbit antibody targeting Vesicular Acetylcholine Transporter. Anti-Vesicular Acetylcholine Transporter Polyclonal Antibody can be used in WB. |
| Synonyms | VACHT, Solute carrier family 18(vesicular monoamine) member 3, Solute carrier family 18(vesicular acetylcholine) member 3, Solute carrier family 18 member 3, SLC18A3, rVAT, MGC12716 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Rabbit) |
| Verified Activity | Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Rat Cerebrum tissue lysates Lane 3: Human SH-SY5Y cell lysates Primary: Anti-Vesicular Acetylcholine Transporter (TMAB-01960) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 57 kDa Observed band size: 60 kDa  |
| Application | WB |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Peripheral and central cholinergic nervous systems. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Vesicular Acetylcholine Transporter (VAChT), (~70kD protein), belongs to the family of vesicular monoamine transporters(VMATs), which include VMAT1 and VMAT2 and the C.elegans putative ACh transporter unc-17. Members of this family function to concentrate neurotransmitters into synaptic vesicles through exchange of protons for neurotransmitters. VAChT is a functional transporter for the neurotransmitter acetylcholine(ACh). ACh is synthesized in the cytoplasm by choline acetyl transferase (ChAT) and transported by VAChT into synaptic vesicles where it is stored until released. After release from presynaptic nerve terminals ACh is hydrolyzed by extracellular ACh-esterases(AChE) to choline and acetate. VAChT mRNA is expressed in all known major cholinergic neurons in the central and peripheral nervous system. VAChT is abundantly expressed in the CNS and is mainly localized in small synaptic vesicles in cholinergic nerve terminals. VAChT provides a specific marker for cholinergic neurons for the study of cholinergic transmission in experimental models, in Alzheimer’s disease and other nervous system disorders. |
| Immunogen | KLH conjugated synthetic peptide: human VAT |
| Antigen Species | Human |
| Gene Name | SLC18A3 |
| Gene ID | 6572 |
| Protein Name | Vesicular acetylcholine transporter |
| Uniprot ID | Q16572 |
| Biology Area | Molecular Neuropharmacology,Acetylcholine |
| Function | Involved in acetylcholine transport into synaptic vesicles. |
| Molecular Weight | Theoretical: 57 kDa. Actual: 60 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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